Results 51 to 60 of about 1,774 (156)

Structure, function and regulation of the tight junction protein Tricellulin

, 2012
Die Abdichtung des Interzellularspalts durch die Tight Junctions ist für Epithelien und Endothelien von zentraler Bedeutung, um als effektive Barriere den parazellulären Transport zwischen den Zellen hindurch zu kontrollieren.
Westphal, Julie Katharina
core   +1 more source

Human peritoneal tight junction, transporter and channel expression in health and kidney failure, and associated solute transport

Scientific Reports, 2023
Next to the skin, the peritoneum is the largest human organ, essentially involved in abdominal health and disease states, but information on peritoneal paracellular tight junctions and transcellular channels and transporters relative to peritoneal ...
Eszter Levai, Iva Marinovic, Maria Bartosova, Conghui Zhang, Betti Schaefer, Hanna Jenei, Zhiwei Du, Dorota Drozdz, Günter Klaus, Klaus Arbeiter, Philipp Romero, Vedat Schwenger, Constantin Schwab, Attila J. Szabo, Sotirios G. Zarogiannis, Claus Peter Schmitt   +15 more
doaj   +1 more source

Establishment of a novel probe-based RT-qPCR approach for detection and quantification of tight junctions reveals age-related changes in the gut barriers of broiler chickens.

PLoS ONE, 2021
Tight junctions (TJs) play a dominant role in gut barrier formation, therefore, resolving the structures of TJs in any animal species is crucial but of major importance in fast growing broilers. They are regulated in molecular composition, ultrastructure
J Sophia von Buchholz, Ivana Bilic, Jörg R Aschenbach, Michael Hess, Taniya Mitra, Wageha A Awad   +5 more
doaj   +1 more source

Tricellulin Expression and its Deletion Effects in the Endolymphatic Sac

The Journal of International Advanced Otology, 2019
Abstract   OBJECTIVES: Tricellulin is a tight junction (TJ)-forming protein that participates in the sealing function of tricellular TJs. Tricellulin-knockout (Tric−/−) mice show progressive hearing loss with degeneration of hair cells in the cochlea without physiological or physical disorders.
Ai, Matsubara, Takenori, Miyashita, Ryuhei, Inamoto, Hirofumi, Sakaguchi, Toru, Kamitani, Nozomu, Mori, Hiroshi, Hoshikawa   +6 more
openaire   +2 more sources

Comparison of the performance of raw and Lactobacillus paracasei fermented soybean meal in diets for turbot (Scophthalmus maximus L.): Growth, intestinal morphology, apoptosis, tight junction, and microbiota

Aquaculture Reports, 2022
Fermentation is a promising method to improve the utilization of soybean meal (SM) by fish, and strain is the core of fermentation process. In this study, the effects of Lactobacillus paracasei fermentation on the SM quality were investigated. Also, an 8-
Beili Zhang, Yan Zhang, Meichen Cui, Mengyu Zhang, Jianing Xu, Zhi Zhang, Zhongmin Sui, Lei Wang, Chunyang Zhang, Chaoqun Li, Qinyuan Ma   +10 more
doaj   +1 more source

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, Volume 13, Issue 10, 18 February 2026.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source

Angulins and the Tricellular Tight Junction: Role in Inflammatory Bowel Diseases [PDF]

, 2021
The tight junction (TJ) protects the intestinal barrier function and controls the paracellular transport of water, ions, small water-soluble molecules, and macromolecules. The structure of the TJ comprises the belt-like meshwork of the TJ strands between
Hu, Jiachen
core   +1 more source

A look at tricellulin and its role in tight junction formation and maintenance

European Journal of Cell Biology, 2011
Tight junctions are elaborate networks of transmembrane and cytosolic proteins that regulate epithelial permeability. Tricellulin was the first tight junction protein found at tricellular tight junctions, the specialized structures occurring where three cells meet together. Here, we summarize the current knowledge about tricellulin (marvelD2), a MARVEL
Cibelle, Mariano, Hiroyuki, Sasaki, Dora, Brites, Maria Alexandra, Brito   +3 more
openaire   +2 more sources

Closing the gap: Tricellulin/α-catenin interaction maintains epithelial integrity at vertices

Journal of Cell Biology, 2022
Tricellular junctions play a critical role in regulating epithelial barrier function. In this issue, Cho et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202009037) demonstrate a novel interaction between tricellulin and α-catenin, which connects tricellular junctions to the actomyosin cytoskeleton, thus supporting the epithelial barrier at cell ...
Lotte van den Goor, Ann L. Miller
openaire   +2 more sources

Unraveling the Pathogenetic Potential and Immune Crosstalk of Yersinia spp. in Inflammatory Bowel Disease

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Yersinia enterocolitica and Yersinia pseudotuberculosis have been identified as microbiological factors in the multifactorial pathophysiology of inflammatory bowel disease (IBD). Although conventionally associated with self‐limiting gastroenteritis, Yersinia has been increasingly investigated for its potential role in IBD, particularly in genetically ...
Fattaneh Sabzehali, Verena Zerbato, Stefano Di Bella, Stefano Morabito, Mohammad Reza Zali, Abbas Yadegar   +5 more
wiley   +1 more source