Results 31 to 40 of about 1,774 (156)

The Predictive Value of Serum DAO, HDC, and MMP8 for the Gastrointestinal Injury in the Early Stage of Acute Pancreatitis in an Animal Model and a Clinical Study [PDF]

International Journal of General Medicine
Ruoxi Cheng,1,* Jie Wang,1,* Qing Wu,1 Peng Peng,1 Guolin Liao,1 Xiuping Luo,1 Zhihai Liang,2 Jiean Huang,1,* Mengbin Qin1,* 1Department of Gastroenterology, the Second Affiliated Hospital of Guangxi Medical University, Nanning, 530007 ...
Cheng R, Wang J, Wu Q, Peng P, Liao G, Luo X, Liang Z, Huang J, Qin M   +8 more
doaj   +2 more sources

A role for tricellulin in the regulation of gill epithelium permeability [PDF]

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2013
The apical-most region of cell-to-cell contact in a vertebrate epithelium is the tight junction (TJ) complex. It is composed of bicellular TJs (bTJs) that bridge two adjacent epithelial cells and tricellular TJs (tTJs) that are points of contact between three adjoining epithelial cells.
Dennis, Kolosov, Scott P, Kelly
  +9 more sources

Maternal Preconception Antibiotic Exposure Disrupts Microbial Succession: A Transgenerational Risk for Offspring Gut Mucosal Immaturity and Colitis Susceptibility. [PDF]

Adv Sci (Weinh)
This study reveals that maternal antibiotic exposure prior to conception disrupts intergenerational gut microbial succession. By enhancing maternal‐offspring microbial transmission, altering microbial developmental trajectories and increasing selective pressures during community assembly, these disturbances lead to persistent gut mucosal immaturity and
Chen Y, Duan R, Zhang C, Li G, Ji X, Zhang Q, Pei F, Wang K, Duan L.   +8 more
europepmc   +2 more sources

Aged Gut Microbiota Induces Mucosal Transcriptional Dysregulation, Impairing Immune Surveillance. [PDF]

Aging Cell
Aging impaired intestinal mucosal immune homeostasis by altering the epithelial barrier, lamina propria immune cells, follicle‐associated epithelium, and gut microbiota. These changes, particularly the accumulation of pro‐inflammatory bacteria in the gut microbiota, are closely associated with dysregulation of follicle‐associated epithelium gene ...
Wu F, Zhang M, Wu J, Wang Z, Ma Y, Dong L, Cheng L, Ji T, Zheng C, Ren F, Fang B.   +10 more
europepmc   +2 more sources

Identification of amino acids essential for angulin-1/3 binding of the tricellular tight junction binder, angubindin-1. [PDF]

FEBS Open Bio
Angubindin‐1 binds angulin‐1/‐3 at tricellular tight junctions, enhancing intestinal macromolecule permeation. Alanine scanning identified six essential residues (L562, L598, E638, V640, Y643, and K644) of angubindin‐1 critical for binding to angulin‐1/‐3 and permeation‐enhancing activity, providing insights for the development of targeted noninvasive ...
Kuzu T, Iwashita Y, Tachibana K, Nishino I, Niwa Y, Uyeda A, Matsuo K, Nagahama M, Kondoh M.   +8 more
europepmc   +2 more sources

Wharton’s jelly mesenchymal stem cells attenuate global hypoxia-induced learning and memory impairment via preventing blood-brain barrier breakdown [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): Intracerebroventricular (ICV) injections of mesenchymal stem cells (MSCs) may improve the function and structure of blood-brain barrier (BBB), possibly by preserving the BBB integrity.
Tahmineh Mokhtari, Maryam Shayan, Amirmohammad Rezaei Rashnudi, Gholamreza Hassanzadeh, Kobra Mehran Nia   +4 more
doaj   +1 more source

CDT of Clostridioides difficile Induces MLC-Dependent Intestinal Barrier Dysfunction in HT-29/B6 Epithelial Cell Monolayers

Toxins, 2023
Background: Clostridioides difficile binary toxin (CDT) defines the hypervirulence of strains in nosocomial antibiotic-induced colitis with the highest mortality.
Lucas Heils, Martina Schneemann, Ralf Gerhard, Jörg-Dieter Schulzke, Roland Bücker   +4 more
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases. [PDF]

FEBS Lett
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Zeyneloglu C, Babayev H, Ogulur I, Ardicli S, Pat Y, Yazici D, Zhao B, Chang L, Liu X, D'Avino P, Li M, Biçer C, Kurtoğlu Babayev FH, Dhir R, Nadeau KC, Brüggen MC, Akdis M, Akdis CA.   +17 more
europepmc   +2 more sources

Downsloping high-frequency hearing loss due to inner ear tricellular tight junction disruption by a novel ILDR1 mutation in the Ig-like domain. [PDF]

PLoS ONE, 2015
The immunoglobulin (Ig)-like domain containing receptor 1 (ILDR1) gene encodes angulin-2/ILDR1, a recently discovered tight junction protein, which forms tricellular tight junction (tTJ) structures with tricellulin and lipolysis-stimulated lipoprotein ...
Nayoung K D Kim, Tomohito Higashi, Kyoung Yeul Lee, Ah Reum Kim, Shin-ichiro Kitajiri, Min Young Kim, Mun Young Chang, Veronica Kim, Seung-Ha Oh, Dongsup Kim, Mikio Furuse, Woong-Yang Park, Byung Yoon Choi   +12 more
doaj   +1 more source

A Colonic Organoid Model Challenged with the Large Toxins of Clostridioides difficile TcdA and TcdB Exhibit Deregulated Tight Junction Proteins

Toxins, 2023
Background: Clostridioides difficile toxins TcdA and TcdB are responsible for diarrhea and colitis. Lack of functional studies in organoid models of the gut prompted us to elucidate the toxin’s effects on epithelial barrier function and the molecular ...
Martina Schneemann, Lucas Heils, Verena Moos, Franziska Weiß, Susanne M. Krug, January Weiner, Dieter Beule, Ralf Gerhard, Jörg-Dieter Schulzke, Roland Bücker   +9 more
doaj   +1 more source