Tilivalline- and Tilimycin-Independent Effects of Klebsiella oxytoca on Tight Junction-Mediated Intestinal Barrier Impairment [PDF]
, 2019 Klebsiella oxytoca causes antibiotic-associated hemorrhagic colitis and diarrhea. This was attributed largely to its secreted cytotoxins tilivalline and tilimycin, inductors of epithelial apoptosis.
Bücker, Roland +8 more
core +1 more source
Materials Today Bio, 2022 As one of the main functions of vascular endothelial cells, Vascular permeability is determined by four tight junction proteins (TJPs): Zonula Occludens-1 (ZO-1), Claudin-5, Occludin and Tricellulin.
Junyang Huang +7 more
doaj +1 more source
Downsloping high-frequency hearing loss due to inner ear tricellular tight junction disruption by a novel ILDR1 mutation in the Ig-like domain. [PDF]
PLoS ONE, 2015 The immunoglobulin (Ig)-like domain containing receptor 1 (ILDR1) gene encodes angulin-2/ILDR1, a recently discovered tight junction protein, which forms tricellular tight junction (tTJ) structures with tricellulin and lipolysis-stimulated lipoprotein ...
Nayoung K D Kim +12 more
doaj +1 more source
Molecular Therapy: Methods & Clinical Development, 2021 Systemic or localized application of glucocorticoids (GCs) can lead to iatrogenic ocular hypertension, which is a leading cause of secondary open-angle glaucoma and visual impairment.
Paul S. Cassidy +12 more
doaj +1 more source
LSR/angulin-1 is a tricellular tight junction protein involved in blood-brain barrier formation. [PDF]
, 2015 The blood-brain barrier (BBB) is a term used to describe the unique properties of central nervous system (CNS) blood vessels. One important BBB property is the formation of a paracellular barrier made by tight junctions (TJs) between CNS endothelial ...
Arnold, Thomas D +10 more
core +2 more sources
Tight junctions as regulators of tissue remodelling [PDF]
, 2016 Formation of tissue barriers by epithelial and endothelial cells requires neighbouring cells to interact via intercellular junctions, which includes tight junctions.
Balda, MS, Matter, K
core +1 more source
Tricellulin secures the epithelial barrier at tricellular junctions by interacting with actomyosin
Journal of Cell Biology, 2022 The epithelial cell sheet functions as a barrier to prevent invasion of pathogens. It is necessary to eliminate intercellular gaps not only at bicellular junctions, but also at tricellular contacts, where three cells meet, to maintain epithelial barrier function. To that end, tight junctions between adjacent cells must associate as closely as possible,
Yuma Cho +5 more
openaire +2 more sources
A novel pathogenic variant in the MARVELD2 gene causes autosomal recessive non-syndromic hearing loss in an Iranian family [PDF]
, 2018 BACKGROUND AND AIMS: Hearing loss (HL) is the most common sensorineural disorder and one of the most common human defects. HL can be classified according to main criteria, including: the site (conductive, sensorineural and mixed), onset (pre-lingual ...
Hashemzadeh-Chaleshtori, Morteza +7 more
core +1 more source
PLoS ONE, 2019 Tight junctions (TJs) are cellular junctions within the mammalian epithelial cell sheet that function as a physical barrier to molecular transport within the intercellular space. Dysregulation of TJs leads to various diseases.
Daiki Nakatsu +3 more
doaj +1 more source
Expression of Tight Junction Components in Hepatocyte-Like Cells Differentiated from Human Embryonic Stem Cells [PDF]
, 2015 Human embryonic stem cells can be differentiated in vitro into a wide variety of progeny cells by addition of different morphogens and growth factors. Our aim was to monitor the expression pattern of tight junction (TJ) components and various cellular ...
Apáti, Ágota +6 more
core +1 more source