Tricellulin facilitates colorectal cancer metastasis through activation of the TGFβ/SMAD2/3 signalling pathway [PDF]
Frontiers in OncologyBackgroundTricellulin belongs to the TAMP family of proteins and is primarily localized at the tricellular tight junctions. While its role in the progression of cancer has been reported, its importance in the progression of colorectal cancer (CRC ...
Wenfang Yang +7 more
doaj +2 more sources
Myrrh protects against IL-13-induced epithelial barrier breakdown in HT-29/B6 cells [PDF]
Frontiers in Pharmacology, 2023 The oleoresin myrrh has been used for centuries as an anti-inflammatory remedy for a variety of diseases and is said to have a protective effect on the intestinal epithelium.
Helena Hader +4 more
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Epithelial Barrier Dysfunction in Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) via Downregulation of Claudin-1 [PDF]
Cells, 2023 Background: In patients with diarrhea-predominant irritable bowel syndrome (IBS-D), the diarrheal mechanisms are largely unknown, and they were examined in this study on colon biopsies.
Karem Awad +7 more
doaj +2 more sources
Claudin-5, occludin, zonulin and tricellulin levels of children with attention deficit/hyperactivity disorder [PDF]
European Psychiatry, 2023 Introduction Accumulating studies have pointed out that gut-blood and blood-brain barrier dysfunctions due to the alterations in permeability may play a role in the pathophysiology of neurodevelopmental disorders.
H. Ferahkaya +3 more
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A Colonic Organoid Model Challenged with the Large Toxins of Clostridioides difficile TcdA and TcdB Exhibit Deregulated Tight Junction Proteins [PDF]
Toxins, 2023 Background: Clostridioides difficile toxins TcdA and TcdB are responsible for diarrhea and colitis. Lack of functional studies in organoid models of the gut prompted us to elucidate the toxin’s effects on epithelial barrier function and the molecular ...
Martina Schneemann +9 more
doaj +2 more sources
Impaired Intestinal Permeability of Tricellular Tight Junctions in Patients with Irritable Bowel Syndrome with Mixed Bowel Habits (IBS-M) [PDF]
Cells, 2023 Background: The underlying pathophysiology of irritable bowel syndrome (IBS) is still unclear. Our aim was to investigate the pathophysiological mechanisms of diarrhea, constipation, and antigen uptake in mixed-type IBS (IBS-M).
Karem Awad +7 more
doaj +2 more sources
Restoration of colonic barrier function by tofacitinib in experimental colitis: anti-inflammatory effects and decreased expression of claudins-2 and claudin-15 [PDF]
Intestinal ResearchBackground/Aims Inflammatory bowel disease can be triggered by disturbances in intestinal mucosal integrity, leading to bacterial transmigration. The treatment of inflammatory bowel diseases must not only aim to reduce inflammation, but also to reverse ...
Humberto Barbosa da Costa Filho +7 more
doaj +2 more sources
Case report: A novel nonsense mutation in the MARVELD2 gene causes nonsyndromic hearing loss in a China family [PDF]
Frontiers in GeneticsThe MARVELD2 gene is located on chromosome 5q13.2 and is associated with autosomal recessive nonsyndromic hearing loss (OMIM: # 610572). In this study, we identified and reported a novel nonsense mutation in MARVELD2 c.
Chuican Huang +11 more
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Novel compound heterozygous variants in MARVELD2 causing autosomal recessive hearing loss in two Chinese families [PDF]
Molecular Genetics & Genomic MedicineBackground Hereditary hearing loss is an important component of congenital hearing loss. MARVELD2 (OMIM ID:610572), located in the DFNB49 locus, which encodes a tight junction protein tricellulin playing an important role in the sensory epithelial ...
Xinyu Shi +4 more
doaj +2 more sources
Tubuloside B ameliorates blood-brain barrier disruption and cognitive deficits after cerebral ischemia by inhibiting TRIC protein ubiquitination and degradation [PDF]
Journal of NeuroinflammationBackground and purpose Vascular cognitive impairment (VCI) is strongly linked to blood-brain barrier (BBB) dysfunction. This study investigated whether Tubuloside B (Tub-B), a primary bioactive compound of Cistanche tubulosa, ameliorates cognitive ...
Mingli He +8 more
doaj +2 more sources