Roles of protein–protein interactions and monolayer mechanics in tricellulin localization to tricellular tight junctions [PDF]
Biology OpenTricellular tight junctions (tTJs) seal the space between three or more cells in epithelial monolayers. These specialized tight junctions have distinct protein components, including a transmembrane protein tricellulin.
Toiba Mushtaq +7 more
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Deafness in occludin-deficient mice with dislocation of tricellulin and progressive apoptosis of the hair cells [PDF]
Biology Open, 2014 Occludin is the first identified protein in the tight junction (TJ), but its function has remained for the most part obscure. TJs have been demonstrated to play important roles in the inner ear function, and occludin is expressed in all the epithelial ...
Shin-ichiro Kitajiri +5 more
doaj +6 more sources
Contribution of the tricellular tight junction proteins, tricellulin and angulin-1, to paracellular water permeability [PDF]
Journal of Cell Biology, 2021 In epithelia, large amounts of water pass by transcellular and paracellular pathways, driven by the osmotic gradient built up by solutes’ movement.
Ayala Torres, Carlos Mario
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结直肠肛门外科, 2022 [Objectives] To investigate the clinical significance of tricellular tight junction protein (tricellulin) in colorectal cancer and its relationship with angiogenesis.
Li Mengshi +6 more
doaj +2 more sources
Tricellulin, α-Catenin and Microfibrillar-Associated Protein 5 Exhibit Concomitantly Altered Immunosignals along with Vascular, Extracellular and Cytoskeletal Elements after Experimental Focal Cerebral Ischemia [PDF]
International Journal of Molecular Sciences, 2023 Along with initiatives to understand the pathophysiology of stroke in detail and to identify neuroprotective targets, cell-stabilizing elements have gained increasing attention. Although cell culture experiments have indicated that tricellulin, α-catenin
Dominik Michalski, Martin Krueger
exaly +4 more sources
Tricellulin and its role in the epididymal epithelium of the rat [PDF]
Biology of Reproduction, 2015 Tricellulin is a tight-junction protein present at tricellular tight junctions. It has been suggested that basal cells are implicated in the blood-epididymis barrier.
Mandon, Marion, Cyr, Daniel G.
core +5 more sources
Deficiency of angulin-2/ILDR1, a tricellular tight junction-associated membrane protein, causes deafness with cochlear hair cell degeneration in mice. [PDF]
PLoS ONE, 2015 Tricellular tight junctions seal the extracellular spaces of tricellular contacts, where the vertices of three epithelial cells meet, and are required for the establishment of a strong barrier function of the epithelial cellular sheet.
Tomohito Higashi +3 more
doaj +4 more sources
PLoS ONE, 2019 Tight junctions (TJs) are cellular junctions within the mammalian epithelial cell sheet that function as a physical barrier to molecular transport within the intercellular space. Dysregulation of TJs leads to various diseases.
Daiki Nakatsu +3 more
doaj +2 more sources
Tricellulin deficiency affects tight junction architecture and cochlear hair cells [PDF]
Journal of Clinical Investigation, 2013 The two compositionally distinct extracellular cochlear fluids, endolymph and perilymph, are separated by tight junctions that outline the scala media and reticular lamina.
Inna A. Belyantseva +27 more
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Expression of tricellulin in epithelial cells and non-epithelial cells [PDF]
Histology and histopathology, 2013 Tricellulin is the first molecular component of tricellular tight junctions at tricellular contacts where three epithelial cells meet, and it is required for the their formation and maintenance of the epithelial barrier.
Ninomiya, Takafumi +5 more
core +3 more sources