Diesel exhaust particle exposure reduces expression of the epithelial tight junction protein Tricellulin [PDF]
Background While exposure to diesel exhaust particles has been linked to aberrant immune responses in allergic diseases such as asthma, little attention has been paid to their effects on the airway epithelial barrier.
Timothy Smyth +5 more
doaj +3 more sources
Expression of tricellular tight junction proteins and the paracellular macromolecule barrier are recovered in remission of ulcerative colitis [PDF]
Background Ulcerative colitis (UC) has a relapsing and remitting pattern, wherein the underlying mechanisms of the relapse might involve an enhanced uptake of luminal antigens which stimulate the immune response.
Jia-Chen E. Hu +6 more
doaj +2 more sources
[Objectives] To investigate the related molecular mechanisms by which Tricellulin regulates the invasion, migration and metastasis and epithelial-mesenchymal transition (EMT) progression in colorectal cancer. [Methods] Tissue specimens from 40 colorectal
Yang Wenfang +9 more
doaj +2 more sources
Identification of MarvelD3 as a tight junction-associated transmembrane protein of the occludin family [PDF]
Background Tight junctions are an intercellular adhesion complex of epithelial and endothelial cells, and form a paracellular barrier that restricts the diffusion of solutes on the basis of size and charge.
Balda Maria S +3 more
doaj +2 more sources
The Role of Tricellulin in Epithelial Jamming and Unjamming via Segmentation of Tricellular Junctions [PDF]
Collective cellular behavior in confluent monolayers supports physiological and pathological processes of epithelial development, regeneration, and carcinogenesis. Here, the attainment of a mature and static tissue configuration or the local reactivation
Sophie Lohmann +7 more
doaj +7 more sources
Tricellulin Is Expressed in Autotypic Tight Junctions of Peripheral Myelinating Schwann Cells [PDF]
Autotypic tight junctions are formed by tight junction-like structures in three regions of myelinating Schwann cells, the paranodal loops, Schmidt–Lanterman incisures, and outer/inner mesaxons, and various tight junction molecules, including claudin-19 ...
Takafumi Ninomiya +4 more
core +4 more sources
Looking at tricellulin expression in the brain [PDF]
Tese de mestrado. Biologia (Biologia Molecular e Genética). Universidade de Lisboa, Faculdade de Ciências, 2010It was recently reported the existence of a protein, called tricellulin (TRIC), concentrated at tricellular tight junctions (TJ) but also ...
Mariano, Cibelle Neiva Cavalcanti, 1984-
core +5 more sources
Tight junctions (TJs) seal paracellular clefts in epithelia/endothelia and form tissue barriers for proper organ function. TJ-associated marvel proteins (TAMPs: tricellulin, occludin, marvelD3) are thought to be regulatory relevant.
Schmidt-Ott, K.M. +10 more
core +3 more sources
ReFerm® a Fermented Oat Gruel Composition, Improves Colonic Barrier Function and Modulates Tricellulin Expression in Patients With Irritable Bowel Syndrome. [PDF]
Patients with irritable bowel syndrome (IBS) have been shown to have impaired gut barrier function, which may contribute to gut symptoms by allowing substances to pass more easily through the intestinal lining. In this study, the fermented oat‐based preparation ReFerm® reduced gut permeability and strengthened the gut barrier in colonic biopsies from ...
Abruzzese V +6 more
europepmc +2 more sources
The Intestinal Barrier: A Multilayered Gatekeeper Against Systemic Disease. [PDF]
The intestine performs two distinct yet seemingly contradictory functions: the digestion and absorption of nutrients, and the defense against harmful substances and pathogens. The intestinal barrier is a multilayered system maintained by four key components: the physical, chemical, microbiological, and immunological barriers.
Wakabayashi J, Kimura K, Kawauchi T.
europepmc +2 more sources

