Results 41 to 50 of about 1,774 (156)

Impaired Intestinal Permeability of Tricellular Tight Junctions in Patients with Irritable Bowel Syndrome with Mixed Bowel Habits (IBS-M)

Cells, 2023
Background: The underlying pathophysiology of irritable bowel syndrome (IBS) is still unclear. Our aim was to investigate the pathophysiological mechanisms of diarrhea, constipation, and antigen uptake in mixed-type IBS (IBS-M).
Karem Awad, Christian Barmeyer, Christian Bojarski, Oliver Nagel, In-Fah M. Lee, Michal R. Schweiger, Jörg-Dieter Schulzke, Roland Bücker   +7 more
doaj   +1 more source

The endothelium permeability after bioresorbable scaffolds implantation caused by the heterogeneous expression of tight junction proteins

Materials Today Bio, 2022
As one of the main functions of vascular endothelial cells, Vascular permeability is determined by four tight junction proteins (TJPs): Zonula Occludens-1 (ZO-1), Claudin-5, Occludin and Tricellulin.
Junyang Huang, Shuang Ge, Desha Luo, Ruolin Du, Yang Wang, Wanling Liu, Guixue Wang, Tieying Yin   +7 more
doaj   +1 more source

siRNA targeting Schlemm’s canal endothelial tight junctions enhances outflow facility and reduces IOP in a steroid-induced OHT rodent model

Molecular Therapy: Methods & Clinical Development, 2021
Systemic or localized application of glucocorticoids (GCs) can lead to iatrogenic ocular hypertension, which is a leading cause of secondary open-angle glaucoma and visual impairment.
Paul S. Cassidy, Ruth A. Kelly, Ester Reina-Torres, Joseph M. Sherwood, Marian M. Humphries, Anna-Sophia Kiang, G. Jane Farrar, Colm O’Brien, Matthew Campbell, W. Daniel Stamer, Darryl R. Overby, Pete Humphries, Jeffrey O’Callaghan   +12 more
doaj   +1 more source

Serum Zonulin, Claudin-5, junction Adhesion Molecule-A, Occludin and Tricellulin levels in children with autism spectrum disorder [PDF]

International Journal of Developmental Disabilities
Umit Isik, Halil Ibrahim Buyukbayram, Havvanur Eroglu   +2 more
exaly   +2 more sources

Tricellulin in Crohn's disease and ulcerative colitis

The FASEB Journal, 2010
The tight junction (TJ) protein tricellulina (TRIC) is predominantly located in tricellular TJs (tTJ), the meeting points of three cells. There it forms a barrier to macromolecules without affecting ion permeability. However, at low TRIC levels the tTJ forms a pathway for macromolecules.
Susanne M Krug, Christian Bojarski, Anja Fromm, Jörg Dieter Schulzke, Michael Fromm   +4 more
openaire   +1 more source

Tricellulin secures the epithelial barrier at tricellular junctions by interacting with actomyosin

Journal of Cell Biology, 2022
The epithelial cell sheet functions as a barrier to prevent invasion of pathogens. It is necessary to eliminate intercellular gaps not only at bicellular junctions, but also at tricellular contacts, where three cells meet, to maintain epithelial barrier function. To that end, tight junctions between adjacent cells must associate as closely as possible,
Yuma Cho, Daichi Haraguchi, Kenta Shigetomi, Kenji Matsuzawa, Seiichi Uchida, Junichi Ikenouchi   +5 more
openaire   +2 more sources

Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells [PDF]

The Journal of Cell Biology, 2005
For epithelia to function as barriers, the intercellular space must be sealed. Sealing two adjacent cells at bicellular tight junctions (bTJs) is well described with the discovery of the claudins. Yet, there are still barrier weak points at tricellular contacts, where three cells join together. In this study, we identify tricellulin, the first integral
Ikenouchi, Junichi, Furuse, Mikio, Furuse, Kyoko, Sasaki, Hiroyuki, Tsukita, Sachiko, Tsukita, Shoichiro   +5 more
openaire   +2 more sources

Claudin-9 constitutes tight junctions of folliculo-stellate cells in the anterior pituitary gland

Scientific Reports, 2021
The anterior pituitary gland regulates growth, metabolism, and reproduction by secreting hormones. Folliculo-stellate (FS) cells are non-endocrine cells located among hormone-producing cells in the anterior pituitary glands.
Atsuko Y. Higashi, Tomohito Higashi, Kyoko Furuse, Kana Ozeki, Mikio Furuse, Hideki Chiba   +5 more
doaj   +1 more source

The destruction of mucosal barriers, epithelial remodeling, and impaired mucociliary clearance: possible pathogenic mechanisms of Pseudomonas aeruginosa and Staphylococcus aureus in chronic rhinosinusitis

Cell Communication and Signaling, 2023
Chronic rhinosinusitis (CRS) is a pathological condition characterized by persistent inflammation in the upper respiratory tract and paranasal sinuses.
Zahra Chegini, Milad Noei, Jaber Hemmati, Mohammad Reza Arabestani, Aref Shariati   +4 more
doaj   +1 more source

Association of tricellulin expression with poor colorectal cancer prognosis and metastasis

Oncology Reports, 2020
Tricellulin is a tight‑junction transmembrane protein that regulates cell‑cell interactions. Altered tricellulin expression could promote tumor cell invasions and metastasis in human cancers. The present study assessed tricellulin expression in colorectal cancer tissues for any association with clinicopathological features of colorectal cancer patients
Zhang, Jin-Xiu, Qin, Meng-Bin, Ye, Zhe, Peng, Peng, Li, Si-Man, Song, Qian, Lin, Lan, Liu, Shi-Quan, Xie, Li-Hua, Zhu, Ye, Huang, Jie-An   +10 more
openaire   +3 more sources