Results 81 to 90 of about 2,567 (176)

The microbiota–gut–brain axis in Huntington's disease: pathogenic mechanisms and therapeutic targets

The FEBS Journal, Volume 292, Issue 6, Page 1282-1315, March 2025.
Disturbances of the microbiota–gut–brain axis are evident in people with Huntington's disease (HD) and in HD animal models. Here, we provide an overview of how the trillions of microorganisms residing in the gut, their secretory products, and the microbiota–gut–brain axis may contribute to HD pathogenesis.
Millicent N. Ekwudo, Carolina Gubert, Anthony J. Hannan   +2 more
wiley   +1 more source

Tight junction disruption induced by type 3 secretion system effectors injected by Enteropathogenic and Enterohemorrhagic Escherichia coli

Frontiers in Cellular and Infection Microbiology, 2016
The intestinal epithelium consists of a single cell layer, which is a critical selectively permeable barrier to both absorb nutrients and avoid the entry of potentially harmful entities, including microorganisms. Epithelial cells are held together by the
Paul Ugalde-Silva, Octavio Gonzalez-Lugo, Fernando Navarro-Garcia   +2 more
doaj   +1 more source

Nuclear localization of tricellulin promotes the oncogenic property of pancreatic cancer

Scientific Reports, 2016
AbstractAccumulating evidence has shown that dysregulation of tight junctions (TJs) is involved in tumor development and progression. In this study, we investigated the expression and subcellular distribution of tricellulin, which constitutes tricellular TJs, using human pancreatic adenocarcinomas.
Akira Takasawa, Masaki Murata, Kumi Takasawa, Yusuke Ono, Makoto Osanai, Satoshi Tanaka, Masanori Nojima, Tsuyoshi Kono, Koichi Hirata, Takashi Kojima, Norimasa Sawada   +10 more
openaire   +2 more sources

Epithelial barrier dysfunction and associated diseases in companion animals: Differences and similarities between humans and animals and research needs

Allergy, Volume 79, Issue 12, Page 3238-3268, December 2024.
Abstract Since the 1960s, more than 350,000 new chemicals have been introduced into the lives of humans and domestic animals. Many of them have become part of modern life and some are affecting nature as pollutants. Yet, our comprehension of their potential health risks for both humans and animals remains partial.
Sena Ardicli, Ozge Ardicli, Duygu Yazici, Yagiz Pat, Huseyn Babayev, Peng Xiong, Can Zeyneloglu, Asuncion Garcia‐Sanchez, Li‐Li Shi, Oliva Giannelli Viscardi, Stephen Skolnick, Ismail Ogulur, Raja Dhir, Marek Jutel, Ioana Agache, Jozef Janda, Isabella Pali‐Schöll, Kari C. Nadeau, Mubeccel Akdis, Cezmi A. Akdis   +19 more
wiley   +1 more source

Stroke‐Induced Renal Dysfunction: Underlying Mechanisms and Challenges of the Brain–Kidney Axis

CNS Neuroscience &Therapeutics, Volume 30, Issue 11, November 2024.
After a stroke, multiple pathways in the neurohumoral system are activated. At the same time, the blood–brain barrier is compromised, and pro‐inflammatory substances are released from the brain into the bloodstream, consequently activating the peripheral inflammatory immune response.
Xi Chen, Dong‐Xiao Yang, Heng Zhao, Hong‐Fei Zhang, Pu Hong   +4 more
wiley   +1 more source

Role of the Blood-Brain Barrier in the Formation of Brain Metastases [PDF]

, 2013
The majority of brain metastases originate from lung cancer, breast cancer and malignant melanoma. In order to reach the brain, parenchyma metastatic cells have to transmigrate through the endothelial cell layer of brain capillaries, which forms the ...
Abbott, Ahn, Anfuso, Armulik, Aucoin, Aurrand-Lions, Balda, Barnhill, Bauer, Bos, Brayton, Brightman, Cangara, Carman, Chen, Cohen, Colone, Coussens, Cruz-Munoz, Csilla Fazakas, Cuevas, Daneman, Davies, Dejana, Deli, Denes, Douglas, Duenisch, Fabian, Fan, Farkas, Fidler, Fidler, Furuse, Furuse, Gay, Grinberg-Rashi, Gumbiner, Haskins, Hellstrom, Heon, Hicks, Holland, Hu, Hynes, Ilan, Imola Wilhelm, Inoko, István Krizbai, Izraely, Judit Molnár, János Haskó, Kacem, Khuon, Kienast, Kikuchi, Kim, Kim, Klein, Klein, Konstantopoulos, Krizbai, Krizbai, Krizbai, Krizbai, Krizbai, Lacaz-Vieira, Langer, Langley, Lecht, Lee, Lee, Lee, Li, Lin, Linger, Lockman, Longo, Lorger, Lorger, Lu, Maraveyas, Marchetti, Marchetti, Martin-Padura, Mendes, Mendes, Menter, Mierke, Neuwelt, Nguyen, Nicolson, Nishioku, Nitta, Ohtsuki, Oldendorf, Onodera, Ouban, Paku, Palmieri, Palmieri, Pardridge, Paspalas, Peng, Pestalozzi, Piontek, Platta, Qi, Qi, Reijerkerk, Ridgway, Rolland, Roy, Sahai, Sanz-Moreno, Savettieri, Seike, Shabani, Shimizu, Shintani, Sierra, Sims, Sipos, Stark, Stevenson, Stolp, Takeda, Takenaga, Tester, Tilling, Traweger, Wen, Wilhelm, Wilhelm, Wolburg, Wolf, Wong, Wu, Xie, Yoo, Yoshimasu, Zeljko, Zhang, Zhang, Zohrabian   +144 more
core   +2 more sources

A novel arabinogalactan extracted from Epiphyllum oxypetalum (DC.) Haw improves the immunity and gut microbiota in cyclophosphamide‐induced immunosuppressed mice

eFood, Volume 5, Issue 5, October 2024.
A new type I arabinogalactan (AG‐I) polysaccharide from Epiphyllum oxypetalum (DC.) Haw's flowers (EPS) has immunomodulatory activity in the body. Furthermore, EPS supplementation altered intestinal lactic acid metabolism and enhanced the expression of repair proteins at the base of colonic crypts.
Jin Dai, Zhiwei Zhou, Liangwei Chen, Shujuan Cao, Ke Luo, Jinmei Zhang, András Dinnyés, Dan Wang, Qun Sun   +8 more
wiley   +1 more source

Loss of intestinal epithelial barrier function in Salmonella Enteritidis infection [PDF]

, 2014
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/63704Intestinal infection with Salmonella enterica serotype Enteritidis, a food-borne infection spread to humans especially through contaminated eggs and egg-products as well as undercooked ...
Brufau Bonet, M. Teresa (Maria Teresa), Ferrer i Roig, Ruth, Martín Venegas, Raquel   +2 more
core  

Infiltration of immune cells to the brain and its relation to the pathogenesis of Alzheimer's and Parkinson's diseases

Journal of Neurochemistry, Volume 168, Issue 9, Page 2316-2334, September 2024.
The disruption of the neurovascular unit and the infiltration of the peripheral immune cells into the central nervous system are hallmarks of neurodegenerative diseases. However, so far, the participation of infiltrating cells in the progression of these diseases has not been completely defined.
Citlalli Netzahualcoyotzi, Juan Jair Santillán‐Cigales, Laura Virginia Adalid‐Peralta, Iván Velasco   +3 more
wiley   +1 more source

Tricellulin and Its Role in the Epididymal Epithelium of the Rat1

Biology of Reproduction, 2015
Tricellulin is a tight-junction protein present at tricellular tight junctions. It has been suggested that basal cells are implicated in the blood-epididymis barrier. Basal cells express claudins, a component of tight junctions; however, there is no information regarding the potential architecture or regulation of basal cell-principal cell interactions.
Marion Mandon, Daniel G. Cyr
openaire   +4 more sources