The Evaluation of the Reactivating and Neuroprotective Efficacy of Two Newly Prepared Bispyridinium Oximes (K305, K307) in Tabun-Poisoned Rats—A Comparison with Trimedoxime and the Oxime K203 [PDF]
Molecules, 2017 The ability of two newly developed oximes (K305, K307) to protect tabun-poisoned rats from tabun-induced inhibition of brain acetylcholinesterase, acute neurotoxic signs and symptoms and brain damage was compared with that of the oxime K203 and ...
Jiri Kassa +6 more
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The Evaluation of the Potency of Newly Developed Oximes (K727, K733) and Trimedoxime to Counteract Acute Neurotoxic Effects of Tabun in Rats [PDF]
Acta Medica, 2016 Aim: The ability of two newly developed oximes (K727, K733) to reduce tabun-induced acute neurotoxic signs and symptoms was evaluated and compared with currently available trimedoxime in rats.
Jiří Kassa +2 more
doaj +4 more sources
Acetylcholinesterase reactivators (HI-6, obidoxime, trimedoxime, K027, K075, K127, K203, K282): structural evaluation of human serum albumin binding and absorption kinetics. [PDF]
Int J Mol Sci, 2013 Acetylcholinesterase (AChE) reactivators (oximes) are compounds predominantly targeting the active site of the enzyme. Toxic effects of organophosphates nerve agents (OPNAs) are primarily related to their covalent binding to AChE and ...
Zemek F, Zdarova JK, Sepsova V, Kuca K.
europepmc +5 more sources
Understanding the Interaction Modes and Reactivity of Trimedoxime toward MmAChE Inhibited by Nerve Agents: Theoretical and Experimental Aspects. [PDF]
Int J Mol Sci, 2020 Organophosphorus (OP) compounds are used as both chemical weapons and pesticides. However, these agents are very dangerous and toxic to humans, animals, and the environment.
de Castro AA +6 more
europepmc +2 more sources
FDA-Approved Oximes and Their Significance in Medicinal Chemistry [PDF]
Pharmaceuticals, 2022 Despite the scientific advancements, organophosphate (OP) poisoning continues to be a major threat to humans, accounting for nearly one million poisoning cases every year leading to at least 20,000 deaths worldwide.
Jyothi Dhuguru +2 more
doaj +2 more sources
The benefit of combinations of oximes for the ability of antidotal treatment to counteract sarin-induced brain damage in rats [PDF]
BMC Pharmacology and Toxicology, 2018 Background The aim of our study was to compare the ability of two combinations of oximes (HI-6 + trimedoxime and HI-6 + K203) with atropine to counteract acute sarin-induced brain damage with the efficacy of antidotal treatment involving single oxime (HI-
Filip Caisberger +5 more
doaj +2 more sources
Protective effect of HI-6 and trimedoxime combination in mice acutely poisoned with tabun, dichlorvos or heptenophos [PDF]
Acta Veterinaria, 2012 The aim of this study was to compare the protective effect of two individual oximes (HI-6 and trimedoxime) with their combination in mice acutely poisoned with tabun, dichlorvos or heptenophos.
Antonijević Biljana +2 more
doaj +2 more sources
Novel Group of AChE Reactivators—Synthesis, In Vitro Reactivation and Molecular Docking Study [PDF]
Molecules, 2018 The acetylcholinesterase (AChE) reactivators (e.g., obidoxime, asoxime) became an essential part of organophosphorus (OP) poisoning treatment, together with atropine and diazepam.
David Malinak +4 more
doaj +2 more sources
Targeted Synthesis of 1-(4-Hydroxyiminomethylpyridinium)-3-pyridiniumpropane Dibromide – A New Nerve Agent Reactivator [PDF]
Molecules, 2007 Preparation of 1-(4-hydroxy-iminomethylpyridinium)-3-pyridiniumpropane dibromide is described. This compound represents a new acetylcholinesterase (AChE) reactivator, which has no substituents on the second pyridinium ring as found in other commonly used
Jan Marek +6 more
doaj +2 more sources
Organophosphorus Nerve Agents: Types, Toxicity, and Treatments. [PDF]
J Toxicol, 2020 Organophosphorus compounds are extensively used worldwide as pesticides which cause great hazards to human health. Nerve agents, a subcategory of the organophosphorus compounds, have been produced and used during wars, and they have also been used in terrorist activities.
Mukherjee S, Gupta RD.
europepmc +2 more sources