“People are afraid of getting injections”:Feasibility of community-placed atropine auto-injectors in treating organophosphate poisoning in Sri Lanka [PDF]
IntroductionOrganophosphorus insecticide poisoning remains a major problem in rural low- and middle-income communities. Atropine auto-injectors are used for organophosphorus nerve agent poisoning, but not organophosphorus insecticide poisoning.
Balasuriya, Theekshana +7 more
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Advances in toxicology and medical treatment of chemical warfare nerve agents [PDF]
, 2012 Organophosphorous (OP) Nerve agents (NAs) are known as the deadliest chemical warfare agents. They are divided into two classes of G and V agents. Most of them are liquid at room temperature.
Emadodin Darchini-Maragheh +2 more
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Detoksikacija živčanih bojnih otrova [PDF]
, 2020 Phosphylation of the pivotal enzyme acetylcholinesterase (AChE) by nerve agents (NAs) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter acetylcholine, which induces cholinergic crisis, that is, overstimulation of ...
Nikolina Maček Hrvat, Zrinka Kovarik
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A comparison of the neuroprotective efficacy of newly developed oximes (K117, K127) and currently available oxime (obidoxime) in tabun-poisoned rats [PDF]
The potency of newly developed bispyridinium compounds (K117, K127) to reduce tabun-induced acute neurotoxic signs and symptoms was compared with currently available oxime (obidoxime) using functional observational battery. The neuroprotective effects of
Cabal J. +19 more
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Evaluation of the activity of aromatic aldehydes and their oximes against human erythrocyte acetylcholinesterase enzyme [PDF]
, 2017 Considering the therapeutic importance of the acetylcholinesterase inhibitor drugs, as well, enzyme regenerators drugs, in cases of organophosphate poisoning.
Arlan de Assis Gonsalves +3 more
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Piridinijevi oksimi: razlozi za njihov odabir kao kauzalnih antidota protiv otrovanja organofosfatima i sadašnja rješenja za autoinjektore [PDF]
, 2006 During the last five decades, five pyridinium oximes were found to be worthy of use as antidotes against nerve agents in humans: pralidoxime, in a form of chloride or PAM-2 Cl and mesylate or P2S (against sarin, cyclosarin and VX), trimedoxime or TMB-4 ...
Milan Jokanović +1 more
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Influence of Experimental End Point on the Therapeutic Efficacy of Essential and Additional Antidotes in Organophosphorus Nerve Agent-Intoxicated Mice. [PDF]
Toxics, 2022 Kassa J +4 more
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Formulation And Evaluation Of Fast Disintegrating Sublingual Atropine Tablets For The Potential Treatment Of Acute Organophosphates Toxicity [PDF]
, 2017 Organophosphates (OP) are chemicals found in certain pesticides and in nerve agents such as sarin. Toxicity with these agents can lead to death. On August 2013, 1,300 civilians were killed using sarin gas in Syria by the Assad regimen.
Aodah, Alhussain
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In Vitro Evaluation of Oxidative Stress Induced by Oxime Reactivators of Acetylcholinesterase in HepG2 Cells. [PDF]
Chem Res Toxicol, 2023 Váňová N +5 more
europepmc +1 more source
Курс лекций по фармакологии. Т. 1 [PDF]
, 2013 ФАРМАКОЛОГИЯФАРМАКОКИНЕТИКАЛЕКАРСТВАГОРМОНЫВИТАМИНЫПредставлена краткая информация по основным группам лекарственных средств. Первая часть пособия включает обзор общих сведений по фармакокинетике и фармакодинамике, классификации лекарственных средств, их
Конорев, М. Р. +2 more
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