Results 31 to 40 of about 10,078 (159)

Research advances of trimethylamine N-oxide and chronic kidney diseases

Linchuang shenzangbing zazhi, 2021
Trimethylamine N-oxide（TMAO）is an important gut microbiota-dependent metabolite.Currently many clinical studies have confirmed the correlation between TMAO and the prognosis of chronic kidney disease（CKD）patients.This review summarized the latest ...
Liu Mei-jun, Zhou Wen-hua, Zhao Jing, Cui Wen-Peng   +3 more
doaj  

Fecal Microbiome Composition Does Not Predict Diet‐Induced TMAO Production in Healthy Adults

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Trimethylamine‐N‐oxide (TMAO) is a small molecule derived from the metabolism of dietary nutrients by gut microbes and contributes to cardiovascular disease. Plasma TMAO increases following consumption of red meat.
Marc Ferrell, Peter Bazeley, Zeneng Wang, Bruce S. Levison, Xinmin S. Li, Xun Jia, Ronald M. Krauss, Rob Knight, Aldons J. Lusis, J. C. Garcia‐Garcia, Stanley L. Hazen, W. H. Wilson Tang   +11 more
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Identification and characterization of trimethylamine N-oxide (TMAO) demethylase and TMAO permease in Methylocella silvestris BL2. [PDF]

Environmental microbiology, 2014
Methylocella silvestris, an alphaproteobacterium isolated from a forest soil, can grow on trimethylamine N-oxide (TMAO) as a sole nitrogen source; however, the molecular and biochemical mechanisms underpinning its growth remain unknown. Marker-exchange mutagenesis enabled the identification of several genes involved in TMAO metabolism, including ...
Zhu, Yijun , Jameson, Eleanor, Parslow, Rosemary A., Lidbury, Ian, Fu, Tiantian, Dafforn, Tim, Schäfer, Hendrik, Chen, Yin   +7 more
openaire   +2 more sources

Relationship of Serum Trimethylamine N-Oxide (TMAO) Levels with early Atherosclerosis in Humans [PDF]

Scientific Reports, 2016
AbstractCirculating trimethylamine N-Oxide (TMAO) levels predict cardiovascular disease (CVD), possibly by impacting on cholesterol metabolism and oxidative stress. Because hepatic TMAO production is regulated by insulin signalling and it is unclear whether and to what extent circulating TMAO levels associate with CVD risk, independently of insulin ...
Randrianarisoa, E., Lehn-Stefan, A., Wang, X., Hoene, M., Peter, A., Heinzmann, S.S., Zhao, X., Königsrainer, I., Königsrainer, A., Balletshofer, B., Machann, J., Schick, F., Fritsche, A., Häring, H.-U., Xu, G., Lehmann, R., Stefan, N.   +16 more
openaire   +4 more sources

Effect of urea and tmao on lipid bilayers

European Pharmaceutical Journal, 2017
We study the effect of the osmolytes, Urea and trimethylamine-N-oxide (TMAO) on POPE (1-palmitoyl-2-oleoyl-sn-glycero-3- phosphoethanolamine) lipid membranes using SAXS/WAXS and DSC.
Valerio J., Bernstorff S., Funari S.S.
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Trimethylamine-N-oxide: a potential biomarker and therapeutic target in ischemic stroke

Frontiers in Neurology, 2023
Ischemic stroke is by far the most common cerebrovascular disease and a major burden to the global economy and public health. Trimethylamine-N-oxide (TMAO), a small molecule compound produced by the metabolism of intestinal microorganisms, is reportedly ...
Yuan Liu, Juan Qu, Junjie Xu, Aiming Gu, Dezhi Deng, Xiaodan Jia, Baoxiang Wang   +6 more
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An Expanded Genetic Code Enables Trimethylamine Metabolism in Human Gut Bacteria

mSystems, 2020
Cardiovascular disease (CVD) has been linked to animal-based diets, which are a major source of trimethylamine (TMA), a precursor of the proatherogenic compound trimethylamine-N-oxide (TMAO).
Veronika Kivenson, Stephen J. Giovannoni
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Investigating the Trimethylamine N-Oxide (TMAO) Induced Structure of α-Synuclein [PDF]

Biophysical Journal, 2015
Trimethylamine N-oxide (TMAO) is a naturally occurring osmolyte that is known to stabilize protein structure. Previous studies have shown that the addition of TMAO can induce folding of thermodynamically unstable proteins, causing them to regain high functional activity. In solution, monomeric α-synuclein (αS) is intrinsically disordered.
Ferrie, John J., Wissner, Rebecca F., Petersson, E James   +2 more
openaire   +1 more source

Trimethylamine N-Oxide and Related Metabolites in the Serum and Risk of Type 2 Diabetes in the Chinese Population: A Case-Control Study

Diabetes, Metabolic Syndrome and Obesity, 2023
Shenghong Qi,1,2 Lan Liu,1,2 Shulan He,1,2 Liqun Wang,1,2 Jiangping Li,1,2 Xian Sun1,2 1School of Public Health and Management, Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China; 2The Key Laboratory of Environmental Factors and ...
Qi S, Liu L, He S, Wang L, Li J, Sun X
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Detection of the UV-vis silent biomarker trimethylamine-N-oxide via outer-sphere interactions in a lanthanide metal-organic framework

Communications Chemistry, 2022
Detection of trimethylamine N-oxide (TMAO) can allow for early intervention of cardiovascular disease, but is challenging to achieve using conventional materials and instruments owing to it being spectroscopically silent in the UV-visible region. Here, a
Hui Min, Zhonghang Chen, Zongsu Han, Kunyu Wang, Jun Xu, Wei Shi, Peng Cheng   +6 more
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