Effects of Tropomodulin 2 on Dendritic Spine Reorganization and Dynamics [PDF]
Biomolecules, 2023 Dendritic spines are actin-rich protrusions that receive a signal from the axon at the synapse. Remodeling of cytoskeletal actin is tightly connected to dendritic spine morphology-mediated synaptic plasticity of the neuron.
Balaganesh Kuruba +6 more
doaj +6 more sources
Tropomodulin–Tropomyosin Interplay Modulates Interaction Between Cardiac Myosin and Thin Filaments [PDF]
BiomoleculesTropomodulin (Tmod) is an actin-binding protein that interacts with tropomyosin and the actin filament at the pointed end. The influence of Tmod on the thin filament activation in the myocardium is not clear.
Galina V. Kopylova +9 more
doaj +4 more sources
M6A-modified BFSP1 induces aerobic glycolysis to promote liver cancer growth and metastasis through upregulating tropomodulin 4 [PDF]
Molecular BiomedicineRNA N6-methyladenosine (m6A) is a common RNA modification in eukaryotes, and its abnormal regulation is closely related to cancer progression. Aerobic glycolysis is a main way for cancer cells to obtain energy.
Rong Li +9 more
doaj +4 more sources
Novel secreted STPKLRR from Vibrio splendidus AJ01 promotes pathogen internalization via mediating tropomodulin phosphorylation dependent cytoskeleton rearrangement. [PDF]
PLoS Pathogens, 2023 We previously demonstrated that the flagellin of intracellular Vibrio splendidus AJ01 could be specifically identified by tropomodulin (Tmod) and further mediate p53-dependent coelomocyte apoptosis in the sea cucumber Apostichopus japonicus.
Fa Dai, Ming Guo, Yina Shao, Chenghua Li
doaj +3 more sources
Mutual dependence between tropomodulin and tropomyosin in the regulation of sarcomeric actin assembly in Caenorhabditis elegans striated muscle [PDF]
European Journal of Cell Biology, 2022 Tropomodulin and tropomyosin are important components of sarcomeric thin filaments in striated muscles. Tropomyosin decorates the side of actin filaments and enhances tropomodulin capping at the pointed ends of the filaments.
Shoichiro Ono, Mario Lewis, Kanako Ono
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Correction: Cleavage of tropomodulin-3 by asparagine endopeptidase promotes cancer malignancy by actin remodeling and SND1/RhoA signaling [PDF]
Journal of Experimental & Clinical Cancer Research, 2022 Binghong Chen +13 more
doaj +4 more sources
Journal of Experimental & Clinical Cancer Research, 2022 Background Abnormal proliferation and migration of cells are hallmarks of cancer initiation and malignancy. Asparagine endopeptidase (AEP) has specific substrate cleavage ability and plays a pro-cancer role in a variety of cancers.
Binghong Chen +13 more
doaj +3 more sources
Nodding syndrome is unlikely to be an autoimmune reaction to leiomodin-1 after infection by Onchocerca volvulus [PDF]
Biochemistry and Biophysics Reports, 2023 Nodding syndrome is a neurological disease of children in northern Uganda. Infection with the nematode parasite Onchocerca volvulus has been epidemiologically implicated as the cause of the disease.
Kenneth G. Kodja +5 more
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A nemaline myopathy-linked mutation inhibits the actin-regulatory functions of tropomodulin and leiomodin. [PDF]
Proc Natl Acad Sci U S A, 2023 Significance A single residue in Lmod3 was identified to be essential for the opposite actin filament regulatory functions of tropomodulin (actin filament shortening) and leiomodin (actin filament elongation).
Schultz LE +6 more
europepmc +2 more sources
DAAM is required for thin filament formation and Sarcomerogenesis during muscle development in Drosophila. [PDF]
PLoS Genetics, 2014 During muscle development, myosin and actin containing filaments assemble into the highly organized sarcomeric structure critical for muscle function.
Imre Molnár +14 more
doaj +7 more sources