Actin Filament Pointed Ends: Assays for Regulation of Assembly and Disassembly by Tropomodulin and Tropomyosin. [PDF]
Cytoskeleton (Hoboken)Actin filaments are dynamic polymers whose length depends on regulated monomer association and dissociation at their ends. Actin barbed‐end dynamics are relatively better understood, primarily due to the approximately tenfold faster subunit on/off rates ...
Yamashiro S +5 more
europepmc +5 more sources
M6A-modified BFSP1 induces aerobic glycolysis to promote liver cancer growth and metastasis through upregulating tropomodulin 4 [PDF]
Molecular BiomedicineRNA N6-methyladenosine (m6A) is a common RNA modification in eukaryotes, and its abnormal regulation is closely related to cancer progression. Aerobic glycolysis is a main way for cancer cells to obtain energy.
Rong Li +9 more
doaj +3 more sources
Tropomodulin’s Actin-Binding Abilities Are Required to Modulate Dendrite Development [PDF]
Frontiers in Molecular Neuroscience, 2018 There are many unanswered questions about the roles of the actin pointed end capping and actin nucleation by tropomodulins (Tmod) in regulating neural morphology.
Kevin T. Gray +13 more
doaj +5 more sources
Ecotoxicology and Environmental SafetyEthylene thiourea (ETU), a metabolite of the fungicide ethylene bisdithiocarbamate (EBDC), has received great concern because of its harmful effects. ETU-induced anorectal malformations (ARMs) in rat models have been reported and widely used in the study
Peiqi Liu +7 more
doaj +3 more sources
Actin-binding protein tropomodulin-1 is necessary for basal constriction formation and bud detachment in <i>Hydra vulgaris</i>. [PDF]
iScienceKulkarni S +6 more
europepmc +3 more sources
Multifunctional roles of tropomodulin-3 in regulating actin dynamics [PDF]
Biophysical Reviews, 2018 Tropomodulins (Tmods) are proteins that cap the slow growing (pointed) ends of actin filaments (F-actin). The basis for our current understanding of Tmod function comes from studies in cells with relatively stable and highly organized F-actin networks, leading to the view that Tmod capping functions principally to preserve F-actin stability.
Justin Parreno, Velia M. Fowler
semanticscholar +5 more sources
Tropomodulin Isoform-Specific Regulation of Dendrite Development and Synapse Formation [PDF]
The Journal of Neuroscience, 2018 Neurons of the CNS elaborate highly branched dendritic arbors that host numerous dendritic spines, which serve as the postsynaptic platform for most excitatory synapses.
Omotola F. Omotade +6 more
semanticscholar +4 more sources
Interaction of cardiac leiomodin with the native cardiac thin filament. [PDF]
PLoS BiologyEvery heartbeat depends on cyclical contraction-relaxation produced by the interactions between myosin-containing thick and actin-based thin filaments (TFs) arranged into a crystalline-like lattice in the cardiac sarcomere.
Madison Little +9 more
doaj +2 more sources
Tropomodulin isoforms utilize specific binding functions to modulate dendrite development [PDF]
Cytoskeleton, 2016 Tropomodulins (Tmods) cap F‐actin pointed ends and have altered expression in the brain in neurological diseases. The function of Tmods in neurons has been poorly studied and their role in neurological diseases is entirely unknown. In this article, we show that Tmod1 and Tmod2, but not Tmod3, are positive regulators of dendritic complexity and ...
Kevin T. Gray +6 more
semanticscholar +6 more sources
Tropomyosin-binding properties modulate competition between tropomodulin isoforms. [PDF]
Archives of Biochemistry and Biophysics, 2016 The formation and fine-tuning of cytoskeleton in cells are governed by proteins that influence actin filament dynamics. Tropomodulin (Tmod) regulates the length of actin filaments by capping the pointed ends in a tropomyosin (TM)-dependent manner. Tmod1, Tmod2 and Tmod3 are associated with the cytoskeleton of non-muscle cells and their expression has ...
Mert Colpan +5 more
semanticscholar +4 more sources