Results 21 to 30 of about 4,124 (226)

An Integrated Structural Model of the Palladin-Actin Complex Using XL-MS, SAXS, NMR, and Docking Approaches [PDF]

Structural Dynamics
Palladin is an actin-binding protein that accelerates actin polymerization and is implicated in the metastasis of multiple cancer types. Although three key lysine residues in an immunoglobulin-like domain of palladin have been identified as essential for
Moriah R Beck, Rachel A Sargent, David H Liu, Rahul Yadav   +3 more
doaj   +2 more sources

Genomic organization of Tropomodulins 2 and 4 and unusual intergenic and intraexonic splicing of YL-1 and Tropomodulin 4 [PDF]

BMC Genomics, 2001
Background The tropomodulins (TMODs) are a family of proteins that cap the pointed ends of actin filaments. Four TMODs have been identified in humans, with orthologs in mice.
Zoghbi Huda Y, Siddique Teepu, Cox Patrick R   +2 more
doaj   +3 more sources

Interaction between CDC6 and Tmod3 accelerates resistance to paclitaxel through focal adhesion assembly [PDF]

Signal Transduction and Targeted Therapy
The widespread clinical application of paclitaxel (PTX) in cancer treatment has been significantly limited by the emergence of drug resistance and the presence of drug-tolerant persister cells. To systematically identify key regulators of this resistance,
Yue Liu, Huirui Wang, Jie Zhan, Jiabo Sun, Yan Sun, Xiaojie Fu, Dongxue Lv, Xiuyun Li, Ting Dong, Hongxiang Lou   +9 more
doaj   +2 more sources

Silencing of tropomodulin 1 inhibits acute myeloid leukemia cell proliferation and tumor growth by elevating karyopherin alpha 2–mediated autophagy

Pharmacological Research
Evidence shows that tropomodulin 1 (TMOD1) is a powerful diagnostic marker in the progression of several cancer types. However, the regulatory mechanism of TMOD1 in tumor progression is still unclear.
Yuan Xia, Dan Wang, Huijie Zhao, Tingyi Meng, Qingling Jiang, Zhaohai Pan, Guoli Wang, Tianyue An, Bohan Li, Sixue Bi, Huikai Wang, Jun Lu, Hongfu Liu, Haiyan Lin, Chunhua Lin, Qiusheng Zheng, Defang Li   +16 more
doaj   +2 more sources

A nemaline myopathy–linked mutation inhibits the actin-regulatory functions of tropomodulin and leiomodin [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance A single residue in Lmod3 was identified to be essential for the opposite actin filament regulatory functions of tropomodulin (actin filament shortening) and leiomodin (actin filament elongation).
Lauren E. Schultz, Mert Colpan, Garry E. Smith, Rachel M. Mayfield, Tania M. Larrinaga, Alla S. Kostyukova, Carol C. Gregorio   +6 more
openalex   +2 more sources

Tropomodulin-3 is essential in asymmetric division during mouse oocyte maturation [PDF]

Scientific Reports, 2016
The dynamic polymerization and depolymerization of actin filaments is essential for various cellular processes such as cell migration, rotation, cytokinesis, and mammalian oocyte maturation. Tropomodulin 3 (Tmod3) binds to the slow-growing (pointed) ends
Yu-Jin Jo, W. Jang, Nam-Hyung Kim, S. Namgoong   +3 more
semanticscholar   +4 more sources

YWHAG promotes bladder cancer metastasis by regulating TMOD3 to activate ERK1/2 and JNK phosphorylation in the MAPK pathway [PDF]

Journal of Translational Medicine
Objective This study aims to investigate the molecular mechanisms by which YWHAG (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma) promotes metastasis in bladder cancer.
Tai Tian, Shiming He, Han Hao, Bao Guan, Yanqing Gong, Jian Fan, Zhenpeng Zhu, Wenzhi Gao, Yucai Wu, Ninghan Feng, Aixiang Wang, Yuexian Guo, Xuesong Li   +12 more
doaj   +2 more sources

Tropomodulin-3 [PDF]

Definitions, 2020

semanticscholar   +2 more sources

Cardiac CapZ Regulation During Acute Exercise in Female Mice. [PDF]

FASEB J
CapZ regulates actin addition at the barbed ends of sarcomeric actin. At rest, phosphorylated CapZIP slows addition, and dephosphorylated CapZIP promotes a wobble state to allow actin cycling. During exercise, CapZIP is dephosphorylated to permit increased actin addition at the barbed ends. Increased leiomodin binding to cardiac myofilaments stabilizes
Townsend LK, Wright D, Pyle WG.
europepmc   +2 more sources

The Three-Dimensional Model of the Tropomodulin Assembly at the Pointed End of Actin Filament [PDF]

, 2021
Balaganesh Kuruba, Garry E. Smith, Dmitri Tolkatchev, Alla S. Kostyukova   +3 more
openalex   +2 more sources