Tropomodulin 1 controls erythroblast enucleation via regulation of F-actin in the enucleosome [PDF]
Blood, 2017 Roberta B. Nowak +7 more
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Journal of Biological Chemistry, 2022 Fa Dai, Ming Guo, Yina Shao, Chenghua Li
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Tropomodulin binding to tropomyosins [PDF]
European Journal of Biochemistry, 1992 Tropomodulin is a human erythrocyte membrane cytoskeletal protein that binds to one end of tropomyosin molecules and inhibits tropomyosin binding to actin filaments [Fowler, V. M. (1990) J. Cell Biol. 111, 471–482]. We have characterized the interaction of erythroid and non‐erythroid tropomyosins with tropomodulin by non‐denaturing gel electrophoresis ...
Mark A. Sussman, Velia M. Fowler
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Tropomodulin 1 expression driven by NF-κB enhances breast cancer growth.
Cancer Research, 2015 Triple-negative breast cancers (TNBC), which include the basal-like and claudin-low disease subtypes, are aggressive malignancies for which effective therapeutic targets are lacking.
Taku Ito-Kureha +7 more
semanticscholar +3 more sources
unc-94 Encodes a Tropomodulin in Caenorhabditis elegans [PDF]
Journal of Molecular Biology, 2007 unc-94 is one of about 40 genes in Caenorhabditis elegans that, when mutant, displays an abnormal muscle phenotype. Two mutant alleles of unc-94, su177 and sf20, show reduced motility and brood size and disorganization of muscle structure. In unc-94 mutants, immunofluorescence microscopy shows that a number of known sarcomeric proteins are abnormal ...
Tesheka O. Stevenson +6 more
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Cerebrospinal fluid proteins in relation to longitudinal cognitive trajectories. [PDF]
Alzheimers DementAbstract INTRODUCTION We investigated longitudinal cognitive trajectories in relation to cerebrospinal fluid (CSF) proteomics in Alzheimer's disease (AD). METHODS Differential protein abundance analysis of proteomics (SomaScan 7K) data was performed for composite scores for domain‐specific cognitive functions (memory [MEM], executive function [EF], and
Kim BH +4 more
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Branched-Chain Amino Acid Catabolism Promotes Thrombosis Risk by Enhancing Tropomodulin-3 Propionylation in Platelets [PDF]
Circulation, 2020 Supplemental Digital Content is available in the text. Background: Branched-chain amino acids (BCAAs), essential nutrients including leucine, isoleucine, and valine, serve as a resource for energy production and the regulator of important nutrient and ...
Yanyan Xu +16 more
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Tropomodulin 1 is essential for chemotherapy sensitivity and associated with better outcome in triple-negative breast cancer. [PDF]
BMC CancerTriple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer (BC), characterized by poor clinical behaviors and outcomes. TMOD1 was reported as a downstream target of NF-κB contributing to the growth of cancer cells. However, it’s
Li Y +10 more
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Tropomodulin 1 Regulation of Actin Is Required for the Formation of Large Paddle Protrusions Between Mature Lens Fiber Cells [PDF]
Investigative Ophthalmology and Visual Science, 2016 Purpose To elucidate the proteins required for specialized small interlocking protrusions and large paddle domains at lens fiber cell tricellular junctions (vertices), we developed a novel method to immunostain single lens fibers and studied changes in ...
Catherine Cheng +5 more
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Tropomodulin 3 Binds to Actin Monomers [PDF]
Journal of Biological Chemistry, 2006 Regulation of the actin cytoskeleton by filament capping proteins is critical to myriad dynamic cellular functions. The ability of these proteins to bind both filaments as well as monomers is often central to their cellular functions. The ubiquitous pointed end capping protein Tmod3 (tropomodulin 3) acts as a negative regulator of cell migration, yet ...
Robert Fischer +6 more
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