Results 121 to 130 of about 44,311 (250)

Building coiled coils with polar cores

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Coiled coils are formed by α‐helices winding around each other into superhelical bundles. They are characterized by a specific geometry of interaction, called knobs‐into‐holes, in which residues in the core of the structure mesh regularly along a seam that runs the length of the helices.
Marcus D. Hartmann, Birte Hernandez Alvarez, Mikel Martinez‐Goikoetxea, Andrei N. Lupas   +3 more
wiley   +1 more source

Tropomyosin Isoforms Segregate into Distinct Clusters on Single Actin Filaments

Biomolecules
Tropomyosins (Tpms) are rod-shaped proteins that interact head-to-tail to form a continuous polymer along both sides of most cellular actin filaments. Head-to-tail interaction between adjacent Tpm molecules and the formation of an overlap complex between
Peyman Obeidy, Thomas Sobey, Philip R. Nicovich, Adelle C. F. Coster, Elvis Pandzic   +4 more
doaj   +1 more source

Superposition of ROCK-CC and tropomyosin (PDB code 2d3e).

, 2013
(A) DALI alignment matrix was based on only aligning ROCK-CC chain A to chain C in the tropomyosin structure. The tropomyosin structure is a fusion with the GCN4 leucine zipper; the tropomyosin portion of the structure (residues 176–282) is indicated ...
Michael J. Eck (240706), Daqi Tu (354440), Jarrod A. Marto (104616), Hyun Kyu Song (31003), Yiqun Li (182105), Angela V. Toms (354443), Scott B. Ficarro (354450), Bruce L. Goode (91341), Christopher J. Gould (354447)   +8 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, Volume 20, Issue 9, Page 2262-2279, September 2026.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Not all NTRK fusions in mesenchymal neoplasia are driver events: implications on classification and targeted therapy

The Journal of Pathology: Clinical Research, Volume 12, Issue 5, September 2026.
Abstract NTRK fusions drive the pathogenesis of a distinctive group of mesenchymal neoplasms with significant impact on classification and targeted therapy. However, unexpected NTRK fusions have been reported in other sarcoma entities, raising uncertainty over their specificity and clinical management.
Mohamed A Yakoub, Purvil Sukhadia, Carla Saoud, Meera Hameed, Cristina R Antonescu   +4 more
wiley   +1 more source

Immunological Features of Neuroendocrine Neoplasms and Adrenal Tumors

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Neuroendocrine neoplasms, which occur throughout the human body, as well as adrenocortical carcinoma and pheochromocytoma, which originate in the adrenal gland, are primarily classified as rare malignancies. Immunotherapy, including immune checkpoint inhibitors (ICIs), is generally not incorporated into the standard care protocols for these ...
Akihiro Ohmoto, Shunji Takahashi, Shigehisa Kitano   +2 more
wiley   +1 more source

Metal Ions in Longgu (Fossilized Bone) as a Natural Synergistic Network for Multi‐Target Therapy in Psychiatric Disorders

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Longgu (fossilized bone) delivers a natural synergistic network of metal ions, Ca2+, Mg2+, Zn2+, Fe, Cu, and Mn2+ that collectively targets the interconnected pathologies of anxiety, depression, and insomnia. This multi‐ion system operates through coordinated mechanisms including ionostatic balance, cross‐pathway synergy, and systemic integration ...
Sun Xiujia, Li Zhan Hua, Gao Yuanze, Liu Jing, Li Li, Zhang Chao, Kumar Ganesan, Jianping Chen   +7 more
wiley   +1 more source

Advances in Targeting Central Cholinergic Dysfunction for Neurodegenerative Diseases: From Pharmacotherapy to Neuromodulation

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
This review charts the evolution of cholinergic therapies for neurodegenerative diseases—from classical acetylcholinesterase inhibitors (AChEIs) providing symptomatic relief to precision multi‐target drugs and neuromodulation (VNS, DBS, NIBS) that restore dysfunctional circuits. Emerging gene therapy, cell regeneration, and advanced cholinergic imaging
Lei Lei, Xiaoyu Hu, Ruida Lu, Jian‐jun Yang, Qingsheng Meng   +4 more
wiley   +1 more source

Commentary: Next Generation Sequencing and Linkage Analysis for the Molecular Diagnosis of a Novel Overlapping Syndrome Characterized by Hypertrophic Cardiomyopathy and Typical Electrical Instability of Brugada Syndrome

Frontiers in Physiology, 2017
Michelle M. Monasky, Giuseppe Ciconte, Luigi Anastasia, Luigi Anastasia, Carlo Pappone   +4 more
doaj   +1 more source

Cancer‐related pain: A bidirectional modulator of cancer progression

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
CRP and tumour progression engage in a dynamic, bidirectional circuit mediated by multiple mechanisms involving neuroimmunology and cancer ‐neuroscience. Analgesic interventions may affect tumour progression, while anticancer therapies can influence pain. Targeting pain in cancer may have promising therapeutic value in cancer progression.
Junzhe He, Yu Zhang, Qian Liu, Biao Yan, Peiwei Chai, Renbing Jia   +5 more
wiley   +1 more source