Results 11 to 20 of about 76,365 (337)

Development of a sandwich ELISA and immunochromatographic strip for the detection of shrimp tropomyosin

Food and Agricultural Immunology, 2019
Shrimp tropomyosin is one of the most important causes of shellfish allergy. The objective of this study was to develop a highly sensitive and specific immunoassay for the detection of shrimp tropomyosin in food.
Lu Zeng, Shanshan Song, Qiankun Zheng, Pengjie Luo, Xiaoling Wu, Hua Kuang   +5 more
doaj   +2 more sources

Tropomyosin diffusion over actin subunits facilitates thin filament assembly

Structural Dynamics, 2016
Coiled-coil tropomyosin binds to consecutive actin-subunits along actin-containing thin filaments. Tropomyosin molecules then polymerize head-to-tail to form cables that wrap helically around the filaments. Little is known about the assembly process that
Stefan Fischer, Michael J. Rynkiewicz, Jeffrey R. Moore, William Lehman   +3 more
doaj   +2 more sources

cGMP interacts with tropomyosin and downregulates actin-tropomyosin-myosin complex interaction [PDF]

Respiratory Research, 2018
Background The nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO-sGC-cGMP) signaling pathway, plays a critical role in the pathogenesis of pulmonary arterial hypertension (PAH); however, its exact molecular mechanism remains ...
Lihui Zou, Junhua Zhang, Jingli Han, Wenqing Li, Fei Su, Xiaomao Xu, Zhenguo Zhai, Fei Xiao   +7 more
doaj   +3 more sources

Tropomyosin isoforms and reagents [PDF]

BioArchitecture, 2011
Tropomyosins are rod-like dimers which form head-to-tail polymers along the length of actin filaments and regulate the access of actin binding proteins to the filaments.1 The diversity of tropomyosin isoforms, over 40 in mammals, and their role in an increasing number of biological processes presents a challenge both to experienced researchers and ...
Galina Schevzov, Shane Whittaker, Thomas Fath, Jim J-C. Lin, Peter W. Gunning   +4 more
openalex   +3 more sources

Modulating Shrimp Tropomyosin-Mediated Allergy: Hypoallergen DNA Vaccines Induce Regulatory T Cells to Reduce Hypersensitivity in Mouse Model [PDF]

International Journal of Molecular Sciences, 2019
Shellfish allergy is one of the most common food allergies, with tropomyosin as the major cross-reactive allergen. However, no allergen-specific immunotherapy is clinically available. Recently, we designed two shrimp hypoallergens MEM49 and MED171.
Christine Wai, Nicki Y.H. Leung, Patrick S.C. Leung, Ka Hou Chu   +3 more
openalex   +2 more sources

Tropomyosins [PDF]

Current Biology, 2017
The actin cytoskeleton provides not only the underpinning for cell architecture but also mechanical force and the ability to drive movement of cells and their organelles. It is tempting to think of it simply as a set of stable structural elements, but nothing could be further from the truth.
Peter W, Gunning, Edna C, Hardeman
openaire   +2 more sources

Predicting Effects of Tropomyosin Mutations on Cardiac Muscle Contraction through Myofilament Modeling [PDF]

Frontiers in Physiology, 2016
Point mutations to the human gene TPM1 have been implicated in the development of both hypertrophic and dilated cardiomyopathies. Such observations have led to studies investigating the link between single residue changes and the biophysical behavior of ...
Lorenzo R. Sewanan, Jeffrey R. Moore, William Lehman, Stuart G. Campbell   +3 more
openalex   +2 more sources

TNNT2 mutations in the tropomyosin binding region of TNT1 disrupt its role in contractile inhibition and stimulate cardiac dysfunction

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Roughly two decades ago, troponin T (TnT) of the trimeric thin filament regulatory troponin complex, was shown to contribute directly to the inhibition of skeletal and cardiac muscle contraction, independent of troponins I and C.
Aditi Madan, Meera C. Viswanathan, K. Woulfe, William Schmidt, A. Sidor, Ting Liu, Tran H. Nguyen, Bosco Trinh, Cortney E. Wilson, Sineej Madathil, Georg Vogler, B. O’Rourke, B. Biesiadecki, L. Tobacman, A. Cammarato   +14 more
semanticscholar   +1 more source

Effect of structural stability on endolysosomal degradation and T‐cell reactivity of major shrimp allergen tropomyosin

bioRxiv, 2020
Background Tropomyosins are highly conserved proteins, an attribute that forms the molecular basis for their IgE antibody cross-reactivity. Despite structural similarities, their allergenicity varies greatly between ingested and inhaled invertebrate ...
S. Kamath, S. Scheiblhofer, Christopher M. Johnson, Y. Machado, Thomas R McLean, A. Taki, P. Ramsland, Swati Iyer, I. Joubert, Heidi Hofer, M. Wallner, J. Thalhamer, J. Rolland, R. O'Hehir, P. Briza, F. Ferreira, R. Weiss, A. Lopata   +17 more
semanticscholar   +1 more source

Decreasing Tropomyosin Phosphorylation Rescues Tropomyosin-induced Familial Hypertrophic Cardiomyopathy [PDF]

Journal of Biological Chemistry, 2013
Studies indicate that tropomyosin (Tm) phosphorylation status varies in different mouse models of cardiac disease. Investigation of basal and acute cardiac function utilizing a mouse model expressing an α-Tm protein that cannot be phosphorylated (S283A) shows a compensated hypertrophic phenotype with significant increases in SERCA2a expression and ...
Emily M, Schulz, Tanganyika, Wilder, Shamim A K, Chowdhury, Hajer N, Sheikh, Beata M, Wolska, R John, Solaro, David F, Wieczorek   +6 more
openaire   +2 more sources