Results 101 to 110 of about 57,485 (298)

Predictors of caspofungin exposure-response relationship: a retrospective cohort study on therapeutic drug monitoring parameters

Frontiers in Pharmacology
IntroductionThis study aimed to characterize the exposure-response relationship of caspofungin through analysis of trough serum concentration (Cmin) associated with clinical efficacy, while identifying clinically determinants of Cmin.MethodsA single ...
Mingwei Meng, Ruhua Wei, Yating Lu, Wen Cao, Kai Mo, Zheng Huang, Yane Qin, Xiaobu Lan   +7 more
doaj   +1 more source

Estimation of gas hydrate concentration from multi-component seismic data at sites on the continental margins of NW Svalbard and the Storegga region of Norway [PDF]

, 2008
High-resolution seismic experiments, employing arrays of closely spaced, four-component ocean-bottom seismic recorders, were conducted at a site off western Svalbard and a site on the northern margin of the Storegga slide, off Norway to investigate how ...
Mienert, J., Chand, S., Westbrook, Graham, Reston, Timothy J., Haacke, R. R., Gei, D., Carcione, JM, Dean, S, Mienert, Jürgen, Gei, D, Minshull, TA, Westbrook, G.K., Madrussani, G, Long, C, Reston, T.J., Westbrook, G. K., Flueh, E., Carcione, J.M., Peacock, S., Foucher, JP, Peacock, S, Bünz, S., Carcione, J. M., Flueh, E, Zillmer, Matthias, Zillmer, M, Camerlenghi, A, Rossi, G., Flueh, Ernst R., Chand, S, Foucher, J-P., Haacke, R.R., Minshull, T. A., Vanneste, M, Haacke, RR, Buenz, S, Minshull, T.A., Nouze, H, Camerlenghi, A., Dean, S., Nouzé, H., Rossi, G, Mienert, J, Reston, Timothy, Long, C., Vanneste, M., Foucher, J.-P., Madrussani, G., Zillmer, M.   +48 more
core   +1 more source

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, EarlyView.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source

Risk factors for voriconazole-associated hepatotoxicity in patients with liver dysfunction: a retrospective nested case–control study

Frontiers in Pharmacology
IntroductionVoriconazole is widely used to prevent and treat invasive aspergillosis. However, its use is restricted by adverse effects, including acute liver injury (ALI).
Jing Ren, Xinfeng Cai, Wei Ge, Jinlin Guo, Shan Wang, Qinhui Wang, Linna Liu, Le Yang, Qi Yang   +8 more
doaj   +1 more source

Determinants of Financial Stress and Recovery during the Great Recession [PDF]

In this paper, we explore the link between stress in the domestic financial sector and the capital flight faced by countries in the 2008-9 global crisis.
Gurnain Kaur Pasricha, Joshua Aizenman
core  

Comparison of nevirapine trough concentration in 105 patients with HIV infection.

, 2013
Analysis of variance was utilized to evaluate nevirapine trough concentration in 105 HIV+ patients with 6 consecutive points during follow-up 48 weeks ...
Xiaoli Du (276582), Jing Xie (180526), Yanling Li (269030), Yang Han (269027), Taisheng Li (269024), Zhifeng Qiu (269028), Qiang Fu (129583), Min Ye (171404), Huijuan Kou (276581), Zhu Zhu (142480)   +9 more
core   +1 more source

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

Thermal efficiency and entropy generation for a parabolic trough receiver at different concentration ratios [PDF]

, 2016
Papers presented to the 12th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, Costa de Sol, Spain on 11-13 July 2016.The use of high concentration ratio parabolic trough systems is emerging as one of the ways to further ...
Mwesigye, A., Bello-Ochende, Tunde, Huan, Z., Meyer, Josua P.   +3 more
core  

Specific examples of the optimal trough concentration of VPA for simulated patients.

, 2015
VPA, valproic acid; AED, antiepileptic drug; PHT, phenytoin; SCN1A, sodium channel neuronal type I alpha subunit.Specific examples of the optimal trough concentration of VPA for simulated patients.
Tatsumasa Ono (815881), Kazuki Matsuda (815882), Takateru Ishitsu (654737), Naoki Ogusu (654730), Kentaro Oniki (654736), Masatsugu Shimomasuda (815880), Norio Yasui-Furukori (513798), Hiroo Nakashima (654732), Kazuko Nakagawa (774113), Junji Saruwatari (654731), Miki Nishimura (654734)   +10 more
core   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source