Results 71 to 80 of about 52,480 (256)

Temporal Immune and Metabolic Shifts Drive the Anti‐Tumor Efficacy of Resiquimod‐Loaded Nanoparticles in Peritoneal Carcinomatosis

Advanced Healthcare Materials, EarlyView.
Peritoneal carcinomatosis is a hard‐to‐treat spread of abdominal cancers that often returns after therapy. Nanoparticles were developed to retain an immune‐boosting drug in the abdomen. When combined with chemotherapy in mice, this approach eliminated tumors in many cases and prevented recurrence, helping the immune system mount a stronger, longer ...
Vanessa Chan, Po‐Han Chao, XuXin Sun, Jun Han, Sarah MacPherson, Lucas J. Andrew, Noah Y. Brittain, Tien Do, Marcel B. Bally, Julian J. Lum, Shyh‐Dar Li   +10 more
wiley   +1 more source

A Modular Liver–Microbial Microfluidic Platform to Evaluate Therapeutic and Adverse Effects of Microbial Metabolites

Advanced Healthcare Materials, EarlyView.
This study introduces a modular microfluidic platform that connects liver cells with live microbes to mimic key aspects of the gut–liver interaction in steatosis. Using this system, both microbial metabolites and live bacteria significantly reduced fat accumulation in liver cells, but live microbes triggered inflammation and broader metabolic changes ...
Hsih‐Yin Tan, In Young Hwang, Nanthini Jayabalan, Hui Ling Lee, Louis Jun Ye Ong, Chwee Teck Lim, Matthew Wook Chang, Yi‐Chin Toh   +7 more
wiley   +1 more source

Desalination using a parabolic-trough concentrator

Applied Solar Energy, 2012
There are presented desalination results by using a parabolic-trough concentrator (PTC) device of 5.5 m2, 0.7 m of line focal distance and aligned in the East—West direction. The length of the PTC is 2.5 m and its rectangular absorber cavity has 1m length made of black aluminum. The equipment is located in Cocayalta (48 km from Lima, with 700–850 W/m2)
openaire   +2 more sources

Organic Materials of Tomorrow: Horizons of Artificial Intelligence

Advanced Materials, EarlyView.
This review examines machine learning techniques accelerating the discovery of organic semiconductors by linking molecular structure to properties. Key methods include graph neural networks, generative models, and active learning. Applications to organic photovoltaics demonstrate practical impact.
Harold Mena, J. Terence Blaskovits, Kun‐Han Lin, Denis Andrienko   +3 more
wiley   +1 more source

Is it time to recommend AUC-based vancomycin therapeutic drug monitoring only? A cross-sectional survey in China

Frontiers in Pharmacology
BackgroundThe latest published therapeutic drug monitoring (TDM) guidelines for vancomycin recommend changing trough-based monitoring to area under the concentration-to-time curve (AUC)-based monitoring.
Jieqiong Liu, Jieqiong Liu, Xuan Zhang, Gang Liang, Jianping Zhu, Yi Yang, Ying Zheng, Yun Han, Yun Han, Yun Han, Lingyan Yu, Lingyan Yu, Yuhua Zhao, Zhenwei Yu, Zhenwei Yu   +14 more
doaj   +1 more source

From Payload‐First Toward Dual‐Mechanism Antibody–Drug Conjugates

Advanced Materials, EarlyView.
Conjugation converts potent antibodies into underexposed carriers. This perspective defines the antibody exposure deficit and maps a mechanism‐first design space from payload‐first to antibody‐first ADC architectures, integrating DAR, linker chemistry, and Fc engineering to guide rational design of constructs that balance targeted cytotoxicity with ...
Xavier Pivot, Sebastian Jung, Sébastien Harlepp, Alexandre Detappe   +3 more
wiley   +1 more source

Large‐Scale and Cost‐Effective Fabrication of Ultra‐Thin, Biodegradable Microelectrode Arrays and Pressure Sensors Using Laser Micromachining

Advanced Materials Technologies, EarlyView.
A mask‐free and cost‐effective UV‐pico‐second laser‐based microfabrication method is proposed to fabricate large‐area biodegradable microelectrode arrays and pressure sensors. These devices demonstrate low impedance, good conformability, excellent biocompatibility, and rapid degradation, providing a new route for next‐generation transient electronics ...
Bhavani Prasad Yalagala, Asfand Tanwear, María Cerezo‐Sánchez, Hossein Parvizi, Morteza Amjadi, Hadi Heidari   +5 more
wiley   +1 more source

Collagen‐Based Gut‐on‐Chip for In Vitro Modeling of Intestinal Barrier Function and Host‐Pathogen Interactions

Advanced Materials Technologies, EarlyView.
A collagen‐based gut‐on‐chip model replicates the intestinal extracellular matrix, supporting villi‐like structures, tight junctions, and mucin production. This biomimetic platform enables rapid epithelial differentiation and functional barrier formation.
Fernanda López García, Jacques Leng, Hugo de Oliveira, Pierre Nassoy, Karine Dementhon   +4 more
wiley   +1 more source

Age-Related Differences in Vancomycin-Associated Nephrotoxicity and Efficacy in Methicillin-Resistant Staphylococcus aureus Infection: A Comparative Study between Elderly and Adult Patients

Antibiotics
Elderly patients (age ≥ 65 years) are susceptible to methicillin-resistant Staphylococcus aureus (MRSA) infections, with potential for more adverse treatment outcomes or complications compared to younger adults (18–64 years).
Lin Xi, Shanshan Li, Mengting Chen, Xiaolan Huang, Nanyang Li, Nanye Chen, Hailan Wu, Qiyu Bian, Xingchen Bian, Xin Li, Minjie Yang, Xiaoyu Liang, Jufang Wu, Beining Guo, Yaxin Fan, Jing Zhang   +15 more
doaj   +1 more source

Digital Twin of a One‐Sun‐Driven Luminescent‐Concentrator‐Assisted Planar Solar‐Pumped Fiber Laser

Advanced Optical Materials, EarlyView.
An experimentally‐validated digital twin of a one‐sun solar‐pumped fiber laser enables a design exhibit 13‐times higher output power at 1064 nm to be achieved. Despite its simple appearance, the multitude of choices in the design parameters make finding this improved very tedious in the lab, thus the digital twin can save significant time and effort ...
Anvarjon Sherniyozov, Dmitry Busko, Bryce S. Richards   +2 more
wiley   +1 more source