Results 191 to 200 of about 886,471 (280)

Persistent in vitro nociceptor hyperexcitability and axonal retraction produced by repeated paclitaxel doses

The FEBS Journal, EarlyView.
Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti, Victor Moreno Lozano, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel   +3 more
wiley   +1 more source

The TRP channels serving as chemical-to-electrical signal converter. [PDF]

Physiol Rev
Tian Y, Zheng J.
europepmc   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

Interaction between thermosensitive TRP channels and anoctamin 1. [PDF]

J Physiol Sci
Takayama Y.
europepmc   +1 more source

Defining cellular mechanisms important for painful chemotherapy‐related neuropathy using long‐term primary cultures of nociceptors

The FEBS Journal, EarlyView.
Basic excitability alterations that drive irregular spontaneous activity in primary nociceptors during chemotherapy‐induced peripheral neuropathy. Using an in vitro model of repeated paclitaxel application to dorsal root ganglion neurons that produces progressive axonal degeneration, Lamberti and colleagues show that all three basic excitability ...
Edgar T. Walters
wiley   +1 more source

Role of TRP Channels in Cancer-Induced Bone Pain. [PDF]

Int J Mol Sci
Coluzzi F, Scerpa MS, Alessandri E, Romualdi P, Rocco M.   +4 more
europepmc   +1 more source

The transport of protein aggregates to the vacuole suggests a role for lipid droplets in waste disposal in Saccharomyces cerevisiae

The FEBS Journal, EarlyView.
Lipid droplets (LD) act as cellular ‘garbage trucks’ that transport cytosolic protein aggregates to the vacuole for degradation in yeast. Protein aggregates are docked to lipid droplets in a triacylglycerol‐dependent manner, transported through the cytoplasm, and transferred to the insoluble protein deposit (IPOD) at the vacuole.
Christoph Reiter, Patrick Ebner, Elli Leona Kronsteiner, Sophia Moustakakis, Markus Wiederstein, Astrid Obermayer, Ronald Thomas Huber, Christian Schloegelhofer, Florian Wieser, Jon Cedrick Richter, Isabelle Guirsch, Patrick Rockenfeller, Jana Vojtová, Tomáš Groušl, Thomas Klaus Felder, Mark Rinnerthaler   +15 more
wiley   +1 more source

Unlocking the potential of cardiac TRP channels using knockout mice models. [PDF]

Front Physiol
Kulkarni K, Walton RD, Chaigne S.
europepmc   +1 more source

Defining Sustainability for Multispecies Fisheries and Challenges in Application of Global Certification and Labeling Schemes

Fisheries Management and Ecology, EarlyView.
ABSTRACT Most fisheries in the world do not focus on the capture of only one or two species but harvest multiple species. Multispecies fisheries are challenging to understand and manage, with single species management options often insufficient and/or inappropriate.
Duncan Leadbitter, Rishi Sharma
wiley   +1 more source

Contrasting Food Web Dynamics Across Oceanographic Boundaries in Subarctic Pelagic Ecosystems

Fisheries Oceanography, EarlyView.
ABSTRACT Understanding the structure of pelagic food webs across multiple trophic levels is critical for elucidating species interactions, energy flow, and anthropogenic impacts on production. This study presents a comprehensive analysis of the eastern North Pacific pelagic food webs, focusing on the Gulf of Alaska (GoA) during late winter of 2019.
Genyffer C. Troina, Evgeny A. Pakhomov, Laurie Weitkamp, Brian P. V. Hunt   +3 more
wiley   +1 more source