Results 171 to 180 of about 852,547 (280)

Cannabinoid GPCRs, ectopic olfactory GPCRs and TRP channels: a prespecified baseline-edit-rescue framework for testing higher-order membrane-conditioned integration. [PDF]

Biol Methods Protoc
Yarar E.
europepmc   +1 more source

Persistent in vitro nociceptor hyperexcitability and axonal retraction produced by repeated paclitaxel doses

The FEBS Journal, EarlyView.
Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti, Victor Moreno Lozano, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel   +3 more
wiley   +1 more source

TRP channels in mammalian hearing loss. [PDF]

Front Mol Neurosci
Zhang Z, Wang B.
europepmc   +1 more source

A distinct gene expression mechanism for d‐amino acid utilization in hyperthermophilic archaeon Pyrococcus horikoshii

The FEBS Journal, EarlyView.
The genes PH0137, PH0138, and PH0140 form a cluster in the genome of Pyrococcus horikoshii. The PH0140 gene encodes a transcription factor identified as a d‐amino acid‐responsive regulatory protein (DARP). In feast mode, l‐Ile‐bound DARP binds to the promoter and represses transcription of PH0137 and PH0138. In famine mode, DARP binds to d‐allo‐Ile and
Ryushi Kawakami, Tomoki Kawase, Taira Uehara, Haruhiko Sakuraba, Tomohiko Matsuzawa, Junji Hayashi, Toshihisa Ohshima   +6 more
wiley   +1 more source

TRP Channels in Skin Cancer: Focus on Malignant Melanoma. [PDF]

Int J Mol Sci
Twardak D, Havryliuk V, Gagat M.
europepmc   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

The Role of TRP Channels in Colitis and Inflammatory Bowel Disease: A Systematic Review. [PDF]

Int J Mol Sci
Dvornikova KA, Platonova ON, Bystrova EY.   +2 more
europepmc   +1 more source

Defining cellular mechanisms important for painful chemotherapy‐related neuropathy using long‐term primary cultures of nociceptors

The FEBS Journal, EarlyView.
Basic excitability alterations that drive irregular spontaneous activity in primary nociceptors during chemotherapy‐induced peripheral neuropathy. Using an in vitro model of repeated paclitaxel application to dorsal root ganglion neurons that produces progressive axonal degeneration, Lamberti and colleagues show that all three basic excitability ...
Edgar T. Walters
wiley   +1 more source

TRP channels in epileptogenesis: calcium dysregulation mechanisms and pharmacological targeting strategies. [PDF]

Front Mol Neurosci
Deng G, Liu D, Zhong Y, Wang M, Su B, Jiang H, Zhai Y, Peng H, Zhang C, Feng J.   +9 more
europepmc   +1 more source

TRP Channels and Thermosensation [PDF]

Chemical Senses, 2005
openaire   +2 more sources