Results 101 to 110 of about 42,288 (305)

Research Progress on Upper Airway Cough Syndrome

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Upper airway cough syndrome (UACS) has been identified as a significant contributor to chronic cough in various national guidelines. However, the complexity of its pathogenesis, the lack of clarity surrounding its diagnostic criteria, and its overlap with other etiologies of chronic cough present considerable challenges in both diagnosis and ...
Wan‐Ting Huang, Jia Chen
wiley   +1 more source

The role of TASK-1 and TRPV1 channels in the male reproductive system

Journal of Animal Reproduction and Biotechnology
The mammalian testis is a highly organized organ essential for male reproduction. Its structure comprises seminiferous tubules lined with Sertoli cells, which support spermatogenesis, surrounded by peritubular myoid cells.
Dawon Kang, Eun-A Ko
doaj   +1 more source

Understand spiciness: mechanism of TRPV1 channel activation by capsaicin

Protein & Cell, 2017
Capsaicin in chili peppers bestows the sensation of spiciness. Since the discovery of its receptor, transient receptor potential vanilloid 1 (TRPV1) ion channel, how capsaicin activates this channel has been under extensive investigation using a variety ...
Fan Yang, Jie Zheng
semanticscholar   +1 more source

12(S)-HETE mediates diabetes induced endothelial dysfunction by activating intracellular endothelial cell TRPV1.

Journal of Clinical Investigation, 2020
Diabetic patients develop endothelial dysfunction shortly after diabetes onset that progresses to vascular disease underlying the majority of diabetes associated comorbidities.
M. Otto, C. Bucher, Wantao Liu, Melanie Müller, T. Schmidt, Marina Kardell, Marvin Noel Driessen, J. Rossaint, E. Gross, Nana-Maria Wagner   +9 more
semanticscholar   +1 more source

A Longitudinal Assessment of Endometriosis Patients Prescribed Cannabis‐Based Medicinal Products: A Case Series From the UK Medical Cannabis Registry

Australian and New Zealand Journal of Obstetrics and Gynaecology, EarlyView.
ABSTRACT Background Although there is growing evidence supporting the use of cannabis‐based medicinal products (CBMPs) for the management of chronic pain, there is a paucity of data on their effect on endometriosis‐associated chronic pain. Aims This study aimed to perform an analysis of pain‐specific and general health‐related quality of life (HRQoL ...
Sara Getter, Simon Erridge, John Warner‐Levy, Evonne Clarke, Katy McLachlan, Ross Coomber, Shelley Barnes, Alia Darweish Medniuk, Rahul Guru, Wendy Holden, Mohammed Sajad, Robert Searle, Azfer Usmani, Sanjay Varma, James J. Rucker, Michael Platt, Mikael H. Sodergren   +16 more
wiley   +1 more source

Unique Responses are Observed in Transient Receptor Potential Ankyrin 1 and Vanilloid 1 (TRPA1 and TRPV1) Co-Expressing Cells

Cells, 2014
Transient receptor potential (TRP) ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) receptors are implicated in modulation of cough and nociception. In vivo, TRPA1 and TRPV1 are often co-expressed in neurons and TRPA1V1 hetero-tetramer formation is noted in ...
Laura R. Sadofsky, Koti T. Sreekrishna, Yakang Lin, Renee Schinaman, Kate Gorka, Yogita Mantri, John Christian Haught, Thomas G. Huggins, Robert J. Isfort, Charles C. Bascom, Alyn H. Morice   +10 more
doaj   +1 more source

A Scoping Systematic Review of Cannabis Use in Endometriosis

Australian and New Zealand Journal of Obstetrics and Gynaecology, EarlyView.
ABSTRACT Background Endometriosis, affecting 6%–10% of reproductive‐age women, causes chronic pelvic pain, dysmenorrhea, and infertility. Current treatments have limitations and consequently there is rising interest in effects of cannabis on pain and inflammation associated with endometriosis.
Kindha McLaren, Simon Erridge, Mikael H. Sodergren   +2 more
wiley   +1 more source

TRPV1 Inhibits Ferroptosis and Mitophagy to Alleviate Heart Failure by Activating SFXN2

Frontiers in Bioscience-Landmark
Background: Heart failure (HF) continues to represent a significant global public health concern. Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a calcium-permeable channel that has been linked to cardiac ...
Pan Liu, Shiguang Wang, Liya Li, Ruihua Li, Minming Fan, Jingjing Kong, Bing Gao, Jing Wang, Ran Xia   +8 more
doaj   +1 more source

TRPV1 activity and substance P release are required for corneal cold nociception

Nature Communications, 2019
As a protective mechanism, the cornea is sensitive to noxious stimuli. Here, we show that in mice, a high proportion of corneal TRPM8+ cold-sensing fibers express the heat-sensitive TRPV1 channel.
Fengxian Li, Weishan Yang, Haowu Jiang, Changxiong J. Guo, A. Huang, Hongzhen Hu, Qin Liu   +6 more
semanticscholar   +1 more source

Blue Light Irradiation Induces Human Keratinocyte Cell Damage via Transient Receptor Potential Vanilloid 1 (TRPV1) Regulation

Oxidative Medicine and Cellular Longevity, 2020
Although blue light has been reported to affect skin cells negatively, little is known about its action mechanisms in skin cells. Therefore, we investigated the role of the transient receptor potential vanilloid 1 (TRPV1) in blue light-induced effects on
J. Yoo, Eunbi Yu, See-Hyoung Park, S. Oh, Kitae Kwon, Se Jung Park, Hye-Yeon Kim, Seyoung Yang, Jung Yoen Park, J. Cho, Youn-Jung Kim, Jongsung Lee   +11 more
semanticscholar   +1 more source