Results 121 to 130 of about 25,827 (208)

TRPM3 activation causes CGRP release in trigeminal neurons: Implications for migraine mechanisms

Headache: The Journal of Head and Face Pain, Volume 66, Issue 3, Page 672-687, March 2026.
Abstract Background The transient receptor potential melastatin 3 (TRPM3) ion channel has been implicated in sensory modulation and pain transmission and may contribute to migraine pathophysiology through calcitonin gene‐related peptide (CGRP) release in the trigeminovascular system. This study aimed to investigate TRPM3 activation and its role in CGRP
Philip V. Reducha, Lukas K. S. Nielsen, Mette N. Jensen, Jacob C. A. Edvinsson, Spyridoula Kazantzi, Sofia L. Wæver, Tanja Lylloff, Connar S. J. Westgate, Lars Edvinsson, Kristian A. Haanes   +9 more
wiley   +1 more source

Capsaicin responses in Drosophila: Exploring the possibility of establishing a new Non-TRPV1 model. [PDF]

Biochem Biophys Rep
Flores-Iga G, Amirthalingam M, Lopez-Ortiz C, Nimmakayala P, Reddy UK.   +4 more
europepmc   +1 more source

The exposomal imprint on rosacea: More than skin deep

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 3, Page 387-403, March 2026.
Rosacea reflects systemic and environmental interactions, not just a skin disorder. Key factors include environmental triggers, genetic and microbiome influences, diagnostic gaps in skin of colour and social determinants. Advances in multi‐omics and exposome integration highlight pathways towards precision medicine, prevention and equitable, patient ...
Katerina Grafanaki, Daniella Bakoli Sgourou, Alexandros Maniatis, Efstathia Pasmatzi   +3 more
wiley   +1 more source

Cholesterol inhibits capsaicin activation of the TRPV1 channel. [PDF]

Channels (Austin)
Brandwine-Shemmer T, Barbera NA, Levitan I, Minke B.   +3 more
europepmc   +1 more source

Therapeutic advances in pruritus as a model of personalized medicine

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 3, Page 415-422, March 2026.
Recent advances in itch biology reveal that chronic pruritus arises from distinct neuroimmune pathways driven by cytokines, JAK, BTK and GPCRs. Targeted biologics and small molecule inhibitors such as dupilumab, nemolizumab, remibrutinib and JAK inhibitors precisely modulate these pathways, leading to a new era of personalized therapeutics in pruritus.
Kelsey Auyeung, Ramsey Kubofcik, Brian S. Kim   +2 more
wiley   +1 more source

TRPV1 from the TRP family: Structure, function, implication in autoimmune diseases and potential therapies. [PDF]

Channels (Austin)
Bejoma T, Pan Y, Zhao Q.
europepmc   +1 more source

Second Asian Consensus Report on Functional Dyspepsia (2025): Updated Recommendations

Journal of Gastroenterology and Hepatology, Volume 41, Issue 3, Page 832-853, March 2026.
ABSTRACT Background Functional dyspepsia (FD) is a common gastrointestinal disorder that significantly impacts patients' quality of life. Over a decade ago, the Asian Neurogastroenterology and Motility Association (ANMA) and the Asian Pacific Association of Gastroenterology (APAGE) jointly developed the first Asian consensus report on FD.
Sanjiv Mahadeva, Kewin Tien Ho Siah, Uday C. Ghoshal, Hidekazu Suzuki, Yeong Yeh Lee, Kee Huat Chuah, Vincent Chung, Linda Zhong, Benjamin Wei‐Rong Tay, Ban Hong Ang, Ram Prasad Sinnanaidu, Tao Bai, Tadayuki Oshima, Tanisa Patcharatrakul, Sanjeev Sachdeva, Ping‐Huei Tseng, Jinsong Liu, Yinglian Xiao, Ratha‐Korn Vilaichone, Joon Seong Lee, Jung‐Hwan Oh, Ari Fahrial Syam, Ching Liang Lu, Tiing Leong Ang, In‐Kyung Sung, Xiao‐Hua Hou, Kentaro Sugano, Justin Wu, Hiroto Miwa   +28 more
wiley   +1 more source

Vitamin D3 mediates amelioration of ulcerative colitis via the TRPV1-MAPK signaling pathway. [PDF]

Front Immunol
Zhao K, Li J, Asai Y, Zhang L, Hu Z, Gao H.   +5 more
europepmc   +1 more source

Oral JAK Inhibitors as a Promising Therapeutic Strategy for Refractory Rosacea: A Systematic Review and Meta‐Analysis

Journal of Cosmetic Dermatology, Volume 25, Issue 3, March 2026.
ABSTRACT Background Rosacea is a chronic inflammatory dermatosis. While standard therapies exist, managing refractory subtypes remains a therapeutic challenge. Oral Janus kinase (JAK) inhibitors have emerged as potential alternatives, but systematic evidence is lacking. Aims To evaluate the efficacy and safety of oral JAK inhibitors for rosacea through
Yu Peng, Mingzi Sun, Jiayu Chen, Xubo Huang, Fengchuan Zhang   +4 more
wiley   +1 more source

TRPV1 manipulating polarization of M1/M2 macrophages to promote skeletal muscle regeneration. [PDF]

Skelet Muscle
Liu J, Li N, Jing S, Wu F, An G, Wang L, Li J, Cao X, Sun J.   +8 more
europepmc   +1 more source