Results 131 to 140 of about 25,827 (208)

Genetic deletion of ASIC3 alters left ventricular remodeling and autonomic function after myocardial infarction in mice

Physiological Reports, Volume 14, Issue 5, March 2026.
Abstract Cardiac afferent neurons have been shown to trigger overactivation of neurohormonal systems known to drive adverse cardiac remodeling following myocardial infarction (MI). Acid‐sensing ion channels (ASICs) that are highly expressed in cardiac sympathetic afferents sense ischemia‐induced myocardial acidosis.
Karley M. Monaghan, David D. Gibbons, Chad C. Ward, Maram El‐Geneidy, William J. Kutschke, Kathy A. Zimmerman, Donald A. Morgan, Harald M. Stauss, Anne Marie S. Harding, Michelle C. M. Bader, Peter M. Snyder, Rasna Sabharwal, Robert M. Weiss, Kamal Rahmouni, Christopher J. Benson   +14 more
wiley   +1 more source

Comparison of Receptor Expression and Cholecystokinin Signaling Between Left and Right Nodose Ganglia. [PDF]

Am J Physiol Cell Physiol
Ritchey CR, McCune KX, Peters JH.
europepmc   +1 more source

Anxiofit‐1 and reduction of subthreshold and mild anxiety: Evaluation of a health claim pursuant to article 14 of regulation (EC) No 1924/2006

EFSA Journal, Volume 24, Issue 3, March 2026.
Abstract Following an application from Anxiofit Ltd. pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of Hungary, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked for an opinion on the scientific substantiation of a health claim related to Anxiofit‐1 and reduction of subthreshold and mild ...
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan de Henauw, Karen‐Ildico Hirsch‐Ernst, Angeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Frank Thies, Ines Drenjančević, Ionut Craciun, Alfonso Siani   +17 more
wiley   +1 more source

Pan-cancer analysis of TRPV1: a novel immune infiltration-related biomarker for tumor prognosis and immunotherapy response prediction. [PDF]

BMC Cancer
Wang F, Deng B, Qin M, Cheng Z, Zhang J, Xie G.   +5 more
europepmc   +1 more source

Unraveling Endocannabinoid Signaling Pathways in Cisplatin‐Induced Ototoxicity

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
We performed a comprehensive molecular profiling of the endocannabinoid (eCB) system (ECS) in an auditory Hair cell (HC)‐like cell line (1). Afterwards, we developed suitable in vitro and in vivo models of cisplatin‐induced ototoxicity where we identified distinct components of the ECS (CB2R, DAGLβ and ABHD6) as molecular targets of the drug (2 ...
Sakthimala Palaniappan, Annamaria Tisi, Camilla Di Meo, Cristina Urbano, Georgina E. Fenton, Francesco Della Valle, Federico Fanti, Dario Compagnone, Marc Nazarè, Huib Versnel, Andrea Aramini, Marcello Allegretti, Mauro Maccarrone   +12 more
wiley   +1 more source

Peptide Modulator of TRPV1 Channel Increases Long-Term Potentiation in the Hippocampus and Reduces Anxiety and Fear in Mice Under Acute Stress. [PDF]

Mar Drugs
Pavlov VM, Fedotova AY, Palikov VA, Logashina YA, Zagitova KI, Dyachenko IA, Popov AV, Andreev YA.   +7 more
europepmc   +1 more source

Human Dorsal Root Ganglia Neuronal Cell Line to Study Nociceptive Signaling: A New Pipeline for Pain Therapy

The FASEB Journal, Volume 40, Issue 3, 15 February 2026.
The nociceptive properties of differentiated human HD10.6 cells were characterized by multiple approaches (A). Peripheral sensitization was induced within HD10.6 cells in response to an inflammatory cocktail (B), modeling nociceptors in a chronic pain state.
Sara A. Dochnal, Yixing Du, Daniella Bandari, Kaue Franco Malange, Jack Bryant, Julia Borges Paes Lemes, Abby Whitford, Anna R. Cliffe, Prashant Mali, Kim Dore, Yury I. Miller, Tony L. Yaksh   +11 more
wiley   +1 more source

TRPV1 Downregulation Impairs Prostate Cancer Growth: Functional and Translational Insights from Cellular and <i>In Vivo</i> Models. [PDF]

Int J Biol Sci
Sánchez BG, Mora-Rodríguez JM, Bort A, Palacín A, Sánchez-Rodríguez C, Sánchez-Chapado M, Courraud J, Zoidakis J, Díaz-Laviada I.   +8 more
europepmc   +1 more source

Emerging Role of TRP Channels in Osteoarthritis Pathogenesis. [PDF]

Cells
Yadav S, Yadav J, Humphrey MB.
europepmc   +1 more source

Tumour-brain crosstalk restrains cancer immunity via a sensory-sympathetic axis. [PDF]

Nature
Wei HK, Yu CD, Hu B, Zeng X, Ichise H, Li L, Wang Y, Wang RL, Germain RN, Chang RB, Jin C.   +10 more
europepmc   +1 more source