Results 71 to 80 of about 102,275 (301)

An Overview of Trypanosoma brucei Infections: An Intense Host–Parasite Interaction

Frontiers in Microbiology, 2016
Trypanosoma brucei rhodesiense and T. brucei gambiense, the causative agents of Human African Trypanosomiasis, are transmitted by tsetse flies. Within the vector, the parasite undergoes through transformations that prepares it to infect the human host ...
A. Ponte-Sucre
semanticscholar   +1 more source

Phylogeography and Taxonomy of Trypanosoma brucei

PLoS Neglected Tropical Diseases, 2011
Characterizing the evolutionary relationships and population structure of parasites can provide important insights into the epidemiology of human disease.We examined 142 isolates of Trypanosoma brucei from all over sub-Saharan Africa using three distinct classes of genetic markers (kinetoplast CO1 sequence, nuclear SRA gene sequence, eight nuclear ...
Balmer, O, Beadell, JS, Gibson, WC, Caccone, A   +3 more
openaire   +5 more sources

Bloodstream form trypanosoma brucei depend upon multiple metacaspases associated with RAB11-positive endosomes [PDF]

, 2006
Trypanosoma brucei possesses five metacaspase genes. Of these, MCA2 and MCA3 are expressed only in the mammalian bloodstream form of the parasite, whereas MCA5 is expressed also in the insect procyclic form.
Ambit, Audrey, Appleton, Paul, Coombs, Graham H., Helms, Matthew J., Mottram, Jeremy C., Tetley, Laurence   +5 more
core   +1 more source

Identification and functional characterization of a highly divergent N-acetylglucosaminyltransferase I (TbGnTI) in Trypanosoma brucei [PDF]

, 2014
Trypanosoma brucei expresses a diverse repertoire of N-glycans, ranging from oligomannose and paucimannose structures to exceptionally large complex N-glycans.
Acosta-Serrano, Angela Mehlert, Atrih, Bangs, Bangs, Bendiak, Chang, Cross, Cross, Cross, Di Wu, Doering, Ferguson, Ferguson, Giraudo, Grab, Güther, Harpaz, Ho, Hwa, Ioffe, Izquierdo, Izquierdo, Izquierdo, Izquierdo, Izquierdo, Joao A. Rodrigues, Jones, Kornfeld, Leal, Lombard, M.Lucia S. Güther, Manthri, Manuela Damerow, Mazhari-Tabrizi, Mehlert, Mehlert, Mehlert, Mehlert, Mehlert, Metzler, Michael A.J. Ferguson, Milne, Nagamune, Narimatsu, Nolan, Paschinger, Paulson, Pays, Rovis, Schachter, Sonnhammer, Tabas, Tazeh, Urbaniak, Vella, Visser, Wiggins, Wirtz, Wiśniewski, Zamze   +60 more
core   +2 more sources

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei

PLoS Pathogens, 2017
All cells are subject to structural damage that must be addressed for continued growth. A wide range of damage affects the genome, meaning multiple pathways have evolved to repair or bypass the resulting DNA lesions.
J. A. Stortz, T. D. Serafim, S. Alsford, J. Wilkes, F. Fernández-Cortés, G. Hamilton, E. Briggs, L. Lemgruber, D. Horn, J. Mottram, R. McCulloch   +10 more
semanticscholar   +1 more source

Sleeping sickness [PDF]

, 2011
Artyicle approval pendingHuman African trypanosomiasis (HAT), or sleeping sickness, is a vector-borne disease that flourishes in impoverished, rural parts of sub-Saharan Africa. It is caused by infection with the protozoan parasite Trypanosoma brucei and
Chappuis, F, Malvy, D
core   +2 more sources

Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis

Microbial Cell, 2014
Most African trypanosomes, including the veterinary species Trypanosoma brucei brucei and T. congolense are susceptible to lysis by human serum. A recent study by Alsford et al. [PLoS Pathogens (2014) 10, e1004130] has identified a T. b. brucei lysosomal
Sam Alsford
doaj   +1 more source

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

PROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

Chemical characterisation of Nigerian red propolis and its biological activity against Trypanosoma Brucei.

Phytochemical Analysis, 2016
INTRODUCTION A previous study showed the unique character of Nigerian red propolis from Rivers State, Nigeria (RSN), with regards to chemical composition and activity against Trypanosoma brucei in comparison with other African propolis.
Ruwida M. K. Omar, J. Igoli, A. Gray, G. Ebiloma, C. Clements, James Fearnley, R. Ebel, Tong Zhang, H. D. de Koning, D. Watson   +9 more
semanticscholar   +1 more source