Results 91 to 100 of about 22,217 (248)
ESI MS Studies of T. Brucei Trypanothione Reductase and its Reactions With Selected Metal Compounds
European Journal of Inorganic Chemistry, Volume 27, Issue 36, December 20, 2024.The study investigates the interactions between Trypanothione reductase from Trypanosoma brucei (TbTR) and selected metal compounds using ESI‐MS measurements. The findings describe how these compounds bind to TbTR, highlighting their potential as novel anti‐parasitic agents by targeting this crucial enzyme, which is essential for the parasite's ...
Stefano Zineddu +7 more
wiley +1 more source
The effect of immune inhibition on pleomorphism in Trypanosoma brucei rhodesiense
Parasitology, 1974 The effect of immune inhibition on the pleomorphism of Trypanosoma brucei was studied by counting trypomastigotes and their granules on agar. A statistical analysis is presented. Busulphan 32 mg/kg, given 24 h before inoculation, caused an inhibition of the infection detectable at 72 h, but not thereafter.
W. E. Ormerod +3 more
openaire +3 more sources
Suramin action in African trypanosomes involves a RuvB-like DNA helicase
International Journal for Parasitology: Drugs and Drug Resistance, 2023 Suramin is one of the oldest drugs in use today. It is still the treatment of choice for the hemolymphatic stage of African sleeping sickness caused by Trypanosoma brucei rhodesiense, and it is also used for surra in camels caused by Trypanosoma evansi ...
Anna Albisetti +4 more
doaj
Decoding the network of Trypanosoma brucei proteins that determines sensitivity to apolipoprotein-L1. [PDF]
PLoS Pathogens, 2018 In contrast to Trypanosoma brucei gambiense and T. b. rhodesiense (the causative agents of human African trypanosomiasis), T. b. brucei is lysed by apolipoprotein-L1 (apoL1)-containing human serum trypanolytic factors (TLF), rendering it non-infectious ...
Rachel B Currier +4 more
doaj +1 more source
Pathogens, 2021 Salivarian trypanosomes are extracellular parasites affecting humans, livestock and game animals. Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense are human infective sub-species of T.
Stefan Magez +3 more
doaj +1 more source
Potential Trypanocidal Activity of Glycerol Analogues
ChemistryOpen, Volume 13, Issue 12, December 2024.Trypanosoma brucei is a unicellular parasitic flagellate protozoa causing human African trypanosomiasis and animal African trypanosomiasis. Synthesised glycerol analogues were tested for their potential trypanocidal affects. They caused morphological changes, including detached flagella, cytokinesis defects and ‘big‐eye’ phenotype.
R. A. Humann, T. K. Smith
wiley +1 more source
Current status of antihistamines repurposing for infectious diseases [PDF]
arXiv, 2022 Objectives. This review gathers information on the potential role of antihistamines as anti-infective agents and identifies gaps in research that have impaired its applicability in human health. Methods. The literature search encompassed MEDLINE, PubMed and Google Scholar from 1990 to 2022. Results.
arxiv
Molecules, 2015 Naphthoquinones (NQs) occur naturally in a large variety of plants. Several NQs are highly active against protozoans, amongst them the causative pathogens of neglected tropical diseases such as human African trypanosomiasis (sleeping sickness), Chagas ...
Therese Ellendorff +4 more
doaj +1 more source
Beyond immune escape:a variant surface glycoprotein causes suramin resistance in Trypanosoma brucei [PDF]
, 2017 Suramin is one of the first drugs developed in a medicinal chemistry program (Bayer, 1916), and it is still the treatment of choice for the hemolymphatic stage of African sleeping sickness caused by Trypanosoma brucei rhodesiense.
Cal, Monica +8 more
core +3 more sources
Hydrazinated geraniol derivatives as potential broad‐spectrum antiprotozoal agents
Archiv der Pharmazie, Volume 357, Issue 10, October 2024.Hydrazinated geraniol derivatives were synthesised and tested in vitro against different parasitic protozoans of clinical relevance, including Trypanosoma brucei brucei, Trypanosoma brucei rhodesiense, Trypanosoma cruzi and Leishmania infantum. Compounds 6, 8, 13, 14 and 15 demonstrated low micromolar activity against the different parasites.
Joelien Jooste +4 more
wiley +1 more source