Results 101 to 110 of about 22,217 (248)

Backward Bifurcation and Optimal Control Analysis of a Trypanosoma brucei rhodesiense Model

Mathematics, 2019
In this paper, a mathematical model for the transmission dynamics of Trypanosoma brucei rhodesiense that incorporates three species—namely, human, animal and vector—is formulated and analyzed. Two controls representing awareness campaigns and insecticide
Mlyashimbi Helikumi, M. Kgosimore, Dmitry Kuznetsov, S. Mushayabasa   +3 more
semanticscholar   +1 more source

The role of domestic animals in the epidemiology of human african trypanosomiasis in Ngorongoro conservation area, Tanzania

Parasites & Vectors, 2015
Background Trypanosomiasis is a neglected tropical disease caused by the trypanosome parasite and transmitted by the tsetse fly vector. In Sub-saharan Africa, both the human and animal variants of the disease are a great obstacle towards agriculture ...
Juan P. Ruiz, Hamisi S. Nyingilili, Geofrey H. Mbata, Imna I. Malele   +3 more
doaj   +1 more source

Apolipoprotein L1 Variant Associated with Increased Susceptibility to Trypanosome Infection

mBio, 2016
African trypanosomes, except Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, which cause human African trypanosomiasis, are lysed by the human serum protein apolipoprotein L1 (ApoL1).
Bart Cuypers, Laurence Lecordier, Conor J. Meehan, Frederik Van den Broeck, Hideo Imamura, Philippe Büscher, Jean-Claude Dujardin, Kris Laukens, Achim Schnaufer, Caroline Dewar, Michael Lewis, Oliver Balmer, Thomas Azurago, Sardick Kyei-Faried, Sally-Ann Ohene, Boateng Duah, Prince Homiah, Ebenezer Kofi Mensah, Francis Anleah, Jose Ramon Franco, Etienne Pays, Stijn Deborggraeve   +21 more
doaj   +1 more source

Spatially and genetically distinct African trypanosome virulence variants defined by host interferon-g response [PDF]

, 2007
We describe 2 spatially distinct foci of human African trypansomiasis in eastern Uganda. The Tororo and Soroti foci of <i>Trypanosoma brucei rhodesiense</i> infection were genetically distinct as characterized by 6 microsatellite and 1 ...
Anneli Cooper, Annette MacLeod, Bakhiet M, Bancroft GJ, Cattand P, Hertz CJ, Hunter CA, Jeremy M. Sternberg, Liam Morrison, Lindsay Sweeney, Lorna MacLean, Martin Odiit, Morrison LJ, Page RDM, Peter G. E. Kennedy, Schleifer KW, Schleifer KW, Sternberg JM, Woo PT, World Health Organization   +19 more
core   +1 more source

Cholesterol transport and beyond: Illuminating the versatile functions of HDL apolipoproteins through structural insights and functional implications

BioFactors, Volume 50, Issue 5, Page 922-956, September/October 2024.
High‐density lipoproteins are versatile lipoprotein nanoparticles that have pleotropic functions in regulating lipid metabolism, innate immunity, and protection of cardiovascular system. They comprise of several proteins among which 15 apolipoproteins are the major proteins, with diverse functions.
Aishwarya Sudam Bhale, Olivier Meilhac, Christian Lefebvre d'Hellencourt, Mookambeswaran A. Vijayalakshmi, Krishnan Venkataraman   +4 more
wiley   +1 more source

Antiprotozoal Activity of Azabicyclo-Nonanes Linked to Tetrazole or Sulfonamide Cores

Molecules, 2022
N-(Aminoalkyl)azabicyclo[3.2.2]nonanes possess antiplasmodial and antitrypanosomal activity. A series with terminal tetrazole or sulfonamido partial structure was prepared. The structures of all new compounds were confirmed by NMR and IR spectroscopy and
Johanna Dolensky, Clemens Hinteregger, Andreas Leitner, Werner Seebacher, Robert Saf, Ferdinand Belaj, Pascal Mäser, Marcel Kaiser, Robert Weis   +8 more
doaj   +1 more source

Nanobodies as tools to understand, diagnose, and treat African trypanosomiasis [PDF]

, 2017
African trypanosomes are strictly extracellular protozoan parasites that cause diseases in humans and livestock and significantly affect the economic development of sub-Saharan Africa.
Caljon, Guy, De Baetselier, Patrick, Magez, Stefan, Stijlemans, Benoit, Van Den Abbeele, Jan, Van Ginderachter, Jo A   +5 more
core   +1 more source

Trypanosomes and gut microbiota interactions in triatomine bugs and tsetse flies: A vectorial perspective

Medical and Veterinary Entomology, Volume 38, Issue 3, Page 253-268, September 2024.
Trypanosoma sp. presence modulates or has zero effect on gut microbiota composition. Microbiota presence modulates or has zero effect on Trypanosoma sp. growth. Vector biology of triatomine bugs and tsetse flies influences their gut microbiota composition.
Zeph Nelson Omondi, Ayşe Caner, Suha Kenan Arserim   +2 more
wiley   +1 more source

Evaluation of the TbgI2 and TbgI17 Tandem Repeat Antigens as Potential Antigens for the Diagnosis of Trypanosoma brucei rhodesiense

Open Journal of Clinical Diagnostics, 2019
Human African trypanosomiasis (HAT) affects up to half a million people every year in sub-Saharan Africa. Interruption of transmission of the disease by early diagnosis and treatment is core to the control and eventual elimination of HAT.
Vanessa Irumva, R. Waihenya, A. Mwangi, Peter Kipkemboi, S. Kaneko, Tonny Teya, Joanne Jepkemei, C. Njoroge, Joseph Wambugu Gitari, Matthew Mutinda Munyao, R. M. Irekwa, M. Ng’ang’a, S. Nzou   +12 more
semanticscholar   +1 more source

Determination of the prevalence of African trypanosome species in indigenous dogs of Mambwe district, eastern Zambia, by loop-mediated isothermal amplification

Parasites & Vectors, 2014
Background Dogs have been implicated to serve as links for parasite exchange between livestock and humans and remain an important source of emerging and re-emerging diseases including trypanosome infections.
Malimba Lisulo, Chihiro Sugimoto, Kiichi Kajino, Kyouko Hayashida, Macarthy Mudenda, Ladslav Moonga, Joseph Ndebe, Selestine Nzala, Boniface Namangala   +8 more
doaj   +1 more source