PLoS Neglected Tropical Diseases, 2011 BackgroundAnimal and human trypanosomiasis are constraints to both animal and human health in Sub-Saharan Africa, but there is little recent evidence as to how these parasites circulate in wild hosts in natural ecosystems.
Neil E Anderson +6 more
doaj +1 more source
High frequency of antigenic variation inTrypanosoma brucei rhodesienseinfections
Parasitology, 1989 SUMMARYRates at whichTrypanosoma bruceirhodesiense trypanosomes switch from expression of one variable antigen type (VAT) to that of another have been determined in cloned populations that have been recently tsetse-fly transmitted. Switching rates have been determined between several, specific pairs of VATs in each population.
C M, Turner, J D, Barry
openaire +2 more sources
Development of a safer laboratory vervet monkey model for the study of human African trypanosomiasis
African Journal of Laboratory Medicine, 2014 Background: There are three subspecies of Trypanosoma brucei: T. b. gambiense, T. b. rhodesiense and T. b. brucei. The first two are infectious to humans, whilst T. b. brucei is not. Identifying an animal model of T. b.
Maxwell Waema +5 more
doaj +1 more source
PLoS Neglected Tropical Diseases, 2011 BackgroundTrypanosomiasis is regarded as a constraint on livestock production in Western Kenya where the responsibility for tsetse and trypanosomiasis control has increasingly shifted from the state to the individual livestock owner.
Beatrix von Wissmann +6 more
doaj +1 more source
Discovery and Evaluation of Thiazinoquinones as Anti-Protozoal Agents
Marine Drugs, 2013 Pure compound screening has identified the dioxothiazino-quinoline-quinone ascidian metabolite ascidiathiazone A (2) to be a moderate growth inhibitor of Trypanosoma brucei rhodesiense (IC50 3.1 μM) and Plasmodium falciparum (K1 dual drug resistant ...
Marcel Kaiser +4 more
doaj +1 more source
Updated estimate of the duration of the meningo-encephalitic stage in gambiense human African trypanosomiasis [PDF]
, 2015 Background: The duration of the stages of HAT is an important factor in epidemiological studies and intervention planning. Previously, we published estimates of the duration of the haemo-lymphatic stage 1 and meningo-encephalitic stage 2 of the ...
Chandramohan, Daniel +4 more
core +2 more sources
<i>Trypanosoma brucei rhodesiense</i> Inhibitor of Cysteine Peptidase (ICP) Is Required for Virulence in Mice and to Attenuate the Inflammatory Response. [PDF]
Int J Mol Sci, 2022 Costa TFR +5 more
europepmc +1 more source
An Overview of Trypanosoma brucei Infections: An Intense Host–Parasite Interaction [PDF]
, 2016 Trypanosoma brucei rhodesiense and T. brucei gambiense, the causative agents of Human African Trypanosomiasis, are transmitted by tsetse flies. Within the vector, the parasite undergoes through transformations that prepares it to infect the human host ...
Alicia Ponte-Sucre
core +1 more source
Mouse experiments demonstrate differential pathogenicity and virulence of Trypanosoma brucei rhodesiense strains. [PDF]
Exp Parasitol, 2021 Kipkorir LW +6 more
europepmc +1 more source
Plasma cytokines quantification among Trypanosoma brucei rhodesiense sleeping sickness cases and controls in Rumphi, Malawi. [PDF]
Malawi Med J, 2021 Kamoto K +7 more
europepmc +1 more source