Results 121 to 130 of about 22,217 (248)

Quantitative Structure ‒ Antiprotozoal Activity Relationships of Sesquiterpene Lactones

Molecules, 2009
Prompted by results of our previous studies where we found high activity of some sesquiterpene lactones (STLs) against Trypanosoma brucei rhodesiense (which causes East African sleeping sickness), we have now conducted a structure-(in-vitro)-activity ...
Reto Brun, Sami A. Khalid, Marcel Kaiser, Thomas J. Schmidt, Amal M. M. Nour   +4 more
doaj   +1 more source

Vacuolar ATPase depletion contributes to dysregulation of endocytosis in bloodstream forms of Trypanosoma brucei [PDF]

, 2020
BACKGROUND Vacuolar H-ATPase (V-ATPase) is a highly conserved protein complex which hydrolyzes ATP and pumps protons to acidify vacuolar vesicles.
Hide, G, Lai, D-H, Li, F-J, Lun, Z-R, Xu, Z-S   +4 more
core   +2 more sources

Tractable Quinolone Hydrazides Exhibiting Sub‐Micromolar and Broad Spectrum Antitrypanosomal Activities

ChemMedChem, Volume 19, Issue 9, May 2, 2024.
Several (sub)species of Trypanosoma are responsible for human African trypanosomiasis (HAT), Chagas disease, and Nagana. These (sub)species have different drug susceptibility profiles. This work reports several easily accessed quinolone hydrazides exhibiting sub‐micromolar activities against multiple (sub)species of Trypanosoma.
Kgothatso A. Chirwa, Karol R. Francisco, Phelelisiwe S. Dube, Hayoung Park, Lesetja J. Legoabe, Thaiz Rodrigues Teixeira, Conor R. Caffrey, Richard M. Beteck   +7 more
wiley   +1 more source

Effectiveness of a 10-day melarsoprol schedule for the treatment of late-stage human African trypanosomiasis: confirmation from a multinational study (IMPAMEL II). [PDF]

, 2005
BACKGROUND: Treatment of late-stage human African trypanosomiasis (HAT) with melarsoprol can be improved by shortening the regimen. A previous trial demonstrated the safety and efficacy of a 10-day treatment schedule.
Asumu, P, Bilenge, C M M, Burri, C, Chappuis, F, Doua, F, Josenando, T, Manthelot, C R, Nangouma, A, Richer, M, Schmid, C, Simarro, P   +10 more
core   +2 more sources

Recent developments and challenges in algal protein and peptide extraction strategies, functional and technological properties, bioaccessibility, and commercial applications

Comprehensive Reviews in Food Science and Food Safety, Volume 23, Issue 3, May 2024.
Abstract The burgeoning demand for protein, exacerbated by population growth and recent disruptions in the food supply chain, has prompted a rapid exploration of sustainable protein alternatives. Among these alternatives, algae stand out for their environmental benefits, rapid growth, and rich protein content.
Gulsah Karabulut, Aleksandra Purkiewicz, Gulden Goksen   +2 more
wiley   +1 more source

Estimating the burden of rhodesiense sleeping sickness during an outbreak in Serere, eastern Uganda

BMC Public Health, 2008
Background Zoonotic sleeping sickness, or HAT (Human African Trypanosomiasis), caused by infection with Trypanosoma brucei rhodesiense, is an under-reported and neglected tropical disease.
Coleman Paul G, Odiit Martin, Fèvre Eric M, Woolhouse Mark EJ, Welburn Susan C   +4 more
doaj   +1 more source

In vitro anti‐trypanosomal activity of synthetic nitrofurantoin‐triazole hybrids against Trypanosoma species causing human African trypanosomosis

Fundamental &Clinical Pharmacology, Volume 38, Issue 1, Page 72-83, February 2024.
Abstract Human African trypanosomosis (HAT) which is also known as sleeping sickness is caused by Trypanosoma brucei gambiense that is endemic in western and central Africa and T. b. rhodesiense that is endemic in eastern and southern Africa. Drugs used for treatment against HAT first stage have limited effectiveness, and the second stage drugs have ...
Anna Seetsi, David D. N'da, Nthatisi Molefe‐Nyembe, Keisuke Suganuma, Tsepo Ramatla, Oriel Thekisoe   +5 more
wiley   +1 more source

Design and synthesis of imidazo[1,2‐a]pyridine‐chalcone conjugates as antikinetoplastid agents

Chemical Biology &Drug Design, Volume 103, Issue 1, January 2024.
Imidazo[1,2‐a]pyridine‐chalcone conjugates with antikinetoplastid activity.AbstractA library of imidazo[1,2‐a]pyridine‐appended chalcones were synthesized and characterized using 1H NMR, 13C NMR and HRMS. The synthesized analogues were screened for their antikinetoplastid activity against Trypanosoma cruzi, Trypanosoma brucei brucei, Trypanosoma brucei
Devesh S. Agarwal, Richard M. Beteck, Kayhan Ilbeigi, Guy Caljon, Lesetja J. Legoabe   +4 more
wiley   +1 more source

Dynamics of Immobilized Flagella [PDF]

arXiv, 2003
Although the auger-like 'swimming' motility of the African trypanosome was described upon its discovery over one hundred years ago, the precise biomechanical and biophysical properties of trypanosome flagellar motion has not been elucidated. In this study, we describe five different modes of flagellar beat/wave patterns in African trypanosomes by ...
arxiv  

Evidence for an interplay between cell cycle progression and the initiation of differentiation between life cycle forms of African trypanosomes [PDF]

, 1994
Successful transmission of the African trypanosome between the mammalian host blood-stream and the tsetse fly vector involves dramatic alterations in the parasite's morphology and biochemistry.
Gull, K, Matthews, K R
core   +1 more source