Results 41 to 50 of about 22,217 (248)

Relationship between Trypanosoma brucei rhodesiense genetic diversity and clinical spectrum among sleeping sickness patients in Uganda [PDF]

BMC Res Notes, 2017
Human African trypanosomiasis (HAT) due to Trypanosoma brucei rhodesiense in East and southern Africa is reported to be clinically diverse. We tested the hypothesis that this clinical diversity is associated with a variation in trypanosome genotypes ...
C. Kato, C. Mugasa, A. Nanteza, E. Matovu, V. Alibu   +4 more
semanticscholar   +2 more sources

Interleukin (IL)-6 and IL-10 Are Up Regulated in Late Stage Trypanosoma brucei rhodesiense Sleeping Sickness

PLoS Neglected Tropical Diseases, 2015
Background Sleeping sickness due to Trypanosoma brucei rhodesiense has a wide spectrum of clinical presentations coupled with differences in disease progression and severity across East and Southern Africa.
Charles Drago Kato, Vincent Pius Alibu, Ann Nanteza, Claire Mack Mugasa, Enock Matovu   +4 more
openalex   +3 more sources

Metabolic Profiling of Central Nervous System Disease in Trypanosoma brucei rhodesiense Infection [PDF]

J Infect Dis, 2017
Sabrina Lamour, Vincent Pius Alibu, Elaine Holmes, J. Sternberg   +3 more
openalex   +2 more sources

Virulence and pathogenicity of three Trypanosoma brucei rhodesiense stabilates in a Swiss white mouse model [PDF]

Afr J Lab Med, 2015
Background A key objective in basic research on human African trypanosomiasis (HAT) is developing a cheap and reliable experimental model of the disease for use in pathogenesis and drug studies.
Christopher K. Kariuki, J. Kagira, Victor Mwadime, M. Ngotho   +3 more
semanticscholar   +2 more sources

Transcriptomes of newly-isolated Trypanosoma brucei rhodesiense reveal hundreds of mRNAs that are co-regulated with stumpy-form markers [PDF]

BMC Genomics, 2015
BackgroundDuring natural Trypanosoma brucei infections, the parasites differentiate spontaneously into a non-dividing “stumpy” form when a certain level of parasitaemia is attained.
J. Mulindwa, Clémentine Mercé, E. Matovu, J. Enyaru, C. Clayton   +4 more
semanticscholar   +2 more sources

Roles of cytokines in modulating Trypanosoma brucei rhodesiense infection outcomes in vervet monkeys [PDF]

Vincent O. Adung’a, Clara Jebet, Thuita John, Daniel Masiga, Oidho John, Mark C. Field, Enock Matovu, Benedict Orindi   +7 more
openalex   +2 more sources

Therapeutic Strategies against Leishmania and Trypanosoma

Pathogens, 2023
Human African trypanosomiasis (also known as sleeping sickness, with Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense as etiological agents), American trypanosomiasis (also known as Chagas disease, with Trypanosoma cruzi as the etiological
André L. S. Santos, Igor A. Rodrigues, Claudia M. d’Avila-Levy, Cátia L. Sodré, Koert Ritmeijer, Marta H. Branquinha   +5 more
doaj   +1 more source

Epidemiology of Trypanosomiasis in Wildlife—Implications for Humans at the Wildlife Interface in Africa

Frontiers in Veterinary Science, 2021
While both human and animal trypanosomiasis continue to present as major human and animal public health constraints globally, detailed analyses of trypanosome wildlife reservoir hosts remain sparse.
Keneth Iceland Kasozi, Keneth Iceland Kasozi, Gerald Zirintunda, Fred Ssempijja, Bridget Buyinza, Khalid J. Alzahrani, Kevin Matama, Helen N. Nakimbugwe, Helen N. Nakimbugwe, Luay Alkazmi, David Onanyang, Paul Bogere, Juma John Ochieng, Saher Islam, Wycliff Matovu, David Paul Nalumenya, Gaber El-Saber Batiha, Lawrence Obado Osuwat, Mahmoud Abdelhamid, Tianren Shen, Tianren Shen, Leonard Omadang, Susan Christina Welburn, Susan Christina Welburn   +23 more
doaj   +1 more source

Proteome remodelling during development from blood to insect-form Trypanosoma brucei quantified by SILAC and mass spectrometry [PDF]

BMC Genomics volume 13, 556 (2012), 2021
Background: Trypanosoma brucei is the causative agent of human African sleeping sickness and Nagana in cattle. In addition to being an important pathogen T. brucei has developed into a model system in cell biology. Results: Using Stable Isotope Labelling of Amino acids in Cell culture (SILAC) in combination with mass spectrometry we determined the ...
arxiv   +1 more source

Transcriptome profiles of Trypanosoma brucei rhodesiense in Malawi reveal focus specific gene expression profiles associated with pathology [PDF]

PLoS Negl Trop Dis
Peter Nambala, Harry Noyes, Joyce Namulondo, Oscar A. Nyangiri, Vincent Pius Alibu, Barbara Nerima, Annette MacLeod, Enock Matovu, Janelisa Musaya, Julius Mulindwa   +9 more
openalex   +3 more sources