Spatially and genetically distinct African trypanosome virulence variants defined by host interferon-g response [PDF]
, 2007 We describe 2 spatially distinct foci of human African trypansomiasis in eastern Uganda. The Tororo and Soroti foci of <i>Trypanosoma brucei rhodesiense</i> infection were genetically distinct as characterized by 6 microsatellite and 1 ...
Anneli Cooper +19 more
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Infections with extracellular trypanosomes require control by efficient innate immune mechanisms and can result in the destruction of the mammalian humoral immune system [PDF]
, 2020 Salivarian trypanosomes are extracellular parasites that affect humans, livestock, and game animals around the world. Through co-evolution with the mammalian immune system, trypanosomes have developed defense mechanisms that allow them to thrive in blood,
Magez, Stefan +3 more
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Delineating neuroinflammation, parasite CNS invasion, and blood-brain barrier dysfunction in an experimental murine model of human African trypanosomiasis [PDF]
, 2017 Although Trypanosoma brucei spp. was first detected by Aldo Castellani in CSF samples taken from sleeping sickness patients over a century ago there is still a great deal of debate surrounding the timing, route and effects of transmigration of the ...
Bradley, Barbara +2 more
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Molecules, 2022 Quinones and quinols are secondary metabolites of higher plants that are associated with many biological activities. The oxidative dearomatization of phenols induced by hypervalent iodine(III) reagents has proven to be a very useful synthetic approach ...
Nina Scheiber +5 more
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Plasma neuronal specific enolase : a potential stage diagnostic marker in human African trypanosomiasis [PDF]
, 2014 © The Author 2014. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Mitchell, Julia A, Sternberg, Jeremy M
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PLoS Neglected Tropical Diseases, 2012 Human African Trypanosomiasis (HAT) is caused by two trypanosome sub-species, Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. Drugs available for the treatment of HAT have significant issues related to difficult administration regimes ...
Melissa L Sykes +7 more
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Nanobodies as tools to understand, diagnose, and treat African trypanosomiasis [PDF]
, 2017 African trypanosomes are strictly extracellular protozoan parasites that cause diseases in humans and livestock and significantly affect the economic development of sub-Saharan Africa.
Caljon, Guy +5 more
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Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei.
PLoS Pathogens, 2014 Closely related African trypanosomes cause lethal diseases but display distinct host ranges. Specifically, Trypanosoma brucei brucei causes nagana in livestock but fails to infect humans, while Trypanosoma brucei gambiense and Trypanosoma brucei ...
Sam Alsford +4 more
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Phase II evaluation of sensitivity and specificity of PCR and NASBA followed by oligochromatography for diagnosis of human African trypanosomiasis in clinical samples from D.R. Congo and Uganda. [PDF]
PLoS Neglected Tropical Diseases, 2010 BACKGROUND: The polymerase chain reaction (PCR) and nucleic acid sequence-based amplification (NASBA) have been recently modified by coupling to oligochromatography (OC) for easy and fast visualisation of products.
Enock Matovu +8 more
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Evidence for an interplay between cell cycle progression and the initiation of differentiation between life cycle forms of African trypanosomes [PDF]
, 1994 Successful transmission of the African trypanosome between the mammalian host blood-stream and the tsetse fly vector involves dramatic alterations in the parasite's morphology and biochemistry.
Gull, K, Matthews, K R
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