Results 31 to 40 of about 24,405 (100)

African trypanosomiasis in travelers returning to the United Kingdom. [PDF]

, 2002
Two returning safari tourists with African trypanosomiasis were admitted to the Hospital for Tropical Diseases, London, in a 3-day period, compared with six cases in the previous 14 years.
Agranoff, Dan, Bailey, J Wendi, Chiodini, Peter L, Edwards, Mark, Escombe, Rod, Moore, David AJ, Squire, S Bertel   +6 more
core   +2 more sources

Human African trypanosomiasis amongst urban residents in Kinshasa: a case-control study. [PDF]

, 2004
BACKGROUND: Increasing numbers of human African trypanosomiasis (HAT) cases have been reported in urban residents of Kinshasa, Democratic Republic Congo since 1996. We set up a case-control study to identify risk factors for the disease.
Bilengue CM, Burke J, Dupont WD, Gouteux JP, Gouteux JP, Grebaut P, Magnus E, Meda AH, Mulumba PM, Noireau F, Okia M, Van Hoof L., Van Nieuwenhove S, Watsenga TN, World Health Organisation, Wyatt GB   +15 more
core   +4 more sources

Production of Protease Inhibitor With Penicillium sp. — Optimization of the Medium for Growth in Pellet Form and Cytotoxicity Testing

Engineering in Life Sciences, Volume 25, Issue 3, March 2025.
ABSTRACT Penicillium sp. (IBWF 040‐09) produces a protease inhibitor that can potentially be used against the main protease of human African trypanosomiasis. Since the target substance is formed intracellularly (under nutrient limitation), the fungal pellet is preferred compared to the free mycelia in bioreactor cultivation.
Winda Soerjawinata, Shila Prajapati, Isabelle Barth, Xiaohua Lu, Roland Ulber, Thomas Efferth, Percy Kampeis   +6 more
wiley   +1 more source

Assessment of Willingness to Vaccinate Animals, Pay for Vaccination and Its Contributing Factors in Negele‐Arsi, Shashemene and Hawassa, Ethiopia

Veterinary Medicine and Science, Volume 11, Issue 2, March 2025.
•Vaccines prevent various infectious diseases. However, WTV and WTP for vaccination hindered by multiple challenges. •Overall, 38% of respondents reported as WTV, 36% reported as WTP, whereas 75% chose drugs as a control method over vaccines. •Inaccessibility, high price of vaccines and harm caused by vaccines were noted as a challenge.
Alazar Mekonnen Teffera, Yoseph Cherinet Megerssa   +1 more
wiley   +1 more source

Mechanisms controlling anaemia in Trypanosoma congolense infected mice. [PDF]

, 2009
Trypanosoma congolense are extracellular protozoan parasites of the blood stream of artiodactyls and are one of the main constraints on cattle production in Africa.
A Kobayashi, A Shamseddine, AI Su, AJ Nok, Andy Brass, B Mertens, B Stijlemans, B Stijlemans, B Vanhollebeke, Birgit Rathkolb, BM Bolstad, C Beaumont, C Li, CA Facer, CA Schaer, Delnaz Roshandel, DM Wrighting, E Nemeth, E Nemeth, E Nemeth, Eckard Wolf, Fuad Iraqi, G Weiss, Gd Haan, Gordon Langsley, Harry A. Noyes, HC Greenblatt, Helen Hulme, Helmut Fuchs, HH Kazazian, J Naessens, J Naessens, J Naessens, J Naessens, Jan Naessens, JCM Trail, KAN Esievo, KC Corbit, LY Shih, M Murray, M Murray, M Shi, M Shi, M Sileghem, M Sileghem, Martin Hrabé de Angelis, Mohammad H. Alimohammadian, Morris Agaba, MR Rifkin, N Mabbott, O Van Assendaelft, PM Kristjanson, R Ferreira, RC Gregory, RH Wang, RKG Assoku, RM Ngure, S Kemp, S Kierstein, S Magez, S Magez, S Taniguchi, SH Goh, SJ Kemp, SK Moestrup, Stephen Kemp, T Sato, TC Cheng, Valerie Gailus-Durner, VO Anosa, W Morrison, W Morrison, W Zumkeller, Y Liang, Y Nakamura   +74 more
core   +3 more sources

MIF contributes to Trypanosoma brucei associated immunopathogenicity development [PDF]

, 2014
African trypanosomiasis is a chronic debilitating disease affecting the health and economic well-being of many people in developing countries. The pathogenicity associated with this disease involves a persistent inflammatory response, whereby M1-type ...
Beschin, Alain, Brys, Lea, Bucala, Richard, Caljon, Guy, De Baetselier, Patrick, Leng, Lin, Raes, Geert, Sparkes, Amanda, Stijlemans, Benoit, Van Den Abbeele, Jan, Van Ginderachter, Jo A, Vansintjan, Liese   +11 more
core   +4 more sources

Investigation of Novel Isatinylhydantoin Derivatives as Potential Anti‐Kinetoplastid Agents

ChemMedChem, Volume 20, Issue 1, January 2, 2025.
A series of isatinylhydantoin derivatives were synthesized and investigated for antileishmanial and antitrypanosomal activities in vitro and in vivo. The derivative 5 was identified with higher leishmanicidal activity than the clinical drug amphotericin B while 4b was uncovered as in vitro trypanocidal hit against T. congolense parasite.
Keamogetswe Sechoaro, Janine Aucamp, Christina Kannigadu, Helena D. Janse van Rensburg, Keisuke Suganuma, David D. N'Da   +5 more
wiley   +1 more source

Infections with extracellular trypanosomes require control by efficient innate immune mechanisms and can result in the destruction of the mammalian humoral immune system [PDF]

, 2020
Salivarian trypanosomes are extracellular parasites that affect humans, livestock, and game animals around the world. Through co-evolution with the mammalian immune system, trypanosomes have developed defense mechanisms that allow them to thrive in blood,
Magez, Stefan, Obishakin, Emmanuel Tumininu, Pinto Torres, Joar Esteban, Radwanska, Magdalena   +3 more
core   +1 more source

Exploration of Novel “Ferroxazide/Ferrazone” Derivatives as Antitrypanosomatid Agents: Design, Synthesis, and Biological Efficacy

Applied Organometallic Chemistry, Volume 39, Issue 1, January 2025.
A series of novel ferrocene derivatives, mimics of the clinical antibiotics, nifuroxazide and nitrofurazone, termed ferroxazides and ferrazones, respectively, were synthesized and evaluated for antitrypanosomatid activities. The ferroxazide 15 bearing dimethylamino moiety was identified in vitro as hit against Trypanosoma congolense strain but ...
Christina Kannigadu, Helena D. Janse van Rensburg, Janine Aucamp, Keisuke Suganuma, David D. N'Da   +4 more
wiley   +1 more source

Eflornithine is a cost-effective alternative to melarsoprol for the treatment of second-stage human West African trypanosomiasis in Caxito, Angola. [PDF]

, 2008
OBJECTIVE: To compare the cost-effectiveness of eflornithine and melarsoprol in the treatment of human African trypanosomiasis. METHOD: We used data from a Médecins Sans Frontières treatment project in Caxito, Angola to do a formal cost-effectiveness ...
Adam, Blum, Burri, Burri, Chappuis, Commission for Macroeconomics and Health, Edejer, Evans, Goldie, Legros, Louis, Lutumba, Matovu, Murray, Murray, Pepin, Pepin, Pepin, Politi, Priotto, Robays, Schmid, Schmid, Stanghellini   +23 more
core   +2 more sources