Results 1 to 10 of about 67,971 (99)
The Role of Tryptophan Metabolites in Neuropsychiatric Disorders. [PDF]
Int J Mol Sci, 2022 In recent decades, neuropsychiatric disorders such as major depressive disorder, schizophrenia, bipolar, etc., have become a global health concern, causing various detrimental influences on patients. Tryptophan is an important amino acid that plays an indisputable role in several physiological processes, including neuronal function and immunity ...
Davidson M +3 more
europepmc +4 more sources
Tryptophan metabolites get the gut moving [PDF]
Cell Host & Microbe, 2021 How gut microbes can regulate the enteric nervous system and gut-brain communications is a field of intense research. In this issue of Cell Host & Microbe, Ye et al. demonstrate that bacteria can control intestinal motility and vagal neuronal activation via tryptophan catabolites through the receptor TrpA1 of enteroendocrine cells.
Benech, Nicolas +2 more
openaire +4 more sources
Chromatographic analysis of tryptophan metabolites [PDF]
Journal of Separation Science, 2017 The kynurenine pathway generates multiple tryptophan metabolites called collectively kynurenines and leads to formation of the enzyme cofactor nicotinamide adenine dinucleotide. The first step in this pathway is tryptophan degradation, initiated by the rate‐limiting enzymes indoleamine 2,3‐dioxygenase, or tryptophan 2,3‐dioxygenase, depending on the ...
Ilona Sadok +2 more
openaire +3 more sources
Microanalysis of Tryptophan Metabolites
YAKUGAKU ZASSHI, 1997 In tryptophan metabolites, 3-hydroxykynurenine and 3-hydroxyanthranilic acid have been reported to show a carcinogenic action to mice bladder and the relation of the metabolites to human bladder cancer has been discussed. We developed methods for the fluorometric assay of these compounds and showed that the excretion of 3-hydroxyanthranilic acid ...
openaire +3 more sources
Excretion of tryptophan metabolites in Friedreich's ataxia [PDF]
Journal of Clinical Pathology, 1965 The overnight urinary excretions of the tryptophan metabolites 5-hydroxy indole acetic acid (5HIAA), indole acetic acid (IAA), indoxyl sulphate, and kynurenine were determined in 10 cases of Friedreich's ataxia and in 11 controls. Levels of 5HIAA and IAA were slightly lower and of indoxyl sulphate higher than in the controls but within normal limits ...
N, Robinson, G, Curzon, P, Theaker
openaire +2 more sources
Tryptophan Hydroxylase 1 Regulates Tryptophan and Its Metabolites
International Journal of Molecular SciencesTryptophan hydroxylase (Tph), the rate-limiting enzyme of serotonin (5-hydroxytryptophan; 5-HT) synthesis, exists in two isoforms, Tph1 and Tph2. Tph1 upregulates peripheral 5-HT syn-thesis and blood 5-HT levels, whereas Tph2 upregulates brain 5-HT synthesis.
Katsunori Nonogaki, Takao Kaji
openaire +2 more sources
Modulation of immunity by tryptophan microbial metabolites
Frontiers in Nutrition, 2023 Tryptophan (Trp) is an essential amino acid that can be metabolized via endogenous and exogenous pathways, including the Kynurenine Pathway, the 5-Hydroxyindole Pathway (also the Serotonin pathway), and the Microbial pathway. Of these, the Microbial Trp metabolic pathways in the gut have recently been extensively studied for their production of ...
openaire +3 more sources
Diabetogenic Metabolits of Tryptophan
Bulletin of the Karaganda University “Biology medicine geography Series”The analysis of results investigations of mechanisms of diabetogenic activity of metabolits of abnormal tryptophan metabolism as Xanthurenic acid (XA) are presented in review. Among more than 30 diabetogenic chemicals widely known today XA only is formed in animals and elderly human as result of disturbances of tryptophan metabolism.
G.G. Meyramov +4 more
openaire +1 more source
Photohemolytic activity of tryptophan and phenylalanine metabolites
Acta Dermato-Venereologica, 1974 Abstract is not availeble.
G, Swanbeck, G, Wennersten
openaire +2 more sources
Changes of Lens Crystallins Photosensitized with Tryptophan Metabolites
Ophthalmic Research, 1987 The effect of UV irradiation on bovine lens soluble proteins (crystallins) in the presence of tryptophan metabolites was investigated in vitro. The cross-linking of crystallins by UV irradiation was accelerated by kynurenine, 3-hydroxykynurenine, anthranilic acid and 3-hydroxyanthranilic acid.
H, Ichijima, S, Iwata
openaire +2 more sources