Results 11 to 20 of about 70,579 (241)

Profiling Analysis of Tryptophan Metabolites in the Urine of Patients with Parkinson's Disease Using LC-MS/MS. [PDF]

Pharmaceuticals (Basel), 2023
Although Parkinson’s disease (PD) is a representative neurodegenerative disorder and shows characteristic motor impediments, the pathophysiological mechanisms and treatment targets for PD have not yet been clearly identified.
Chung SH, Yoo D, Ahn TB, Lee W, Hong J.
europepmc   +2 more sources

TrpNet: Understanding Tryptophan Metabolism across Gut Microbiome

Metabolites, 2021
Crosstalk between the gut microbiome and the host plays an important role in animal development and health. Small compounds are key mediators in this host–gut microbiome dialogue.
Yao Lu, Jasmine Chong, Shiqian Shen, Joey-Bahige Chammas, Lorraine Chalifour, Jianguo Xia   +5 more
doaj   +1 more source

Uncovering the specificity and predictability of tryptophan metabolism in lactic acid bacteria with genomics and metabolomics

Frontiers in Cellular and Infection Microbiology, 2023
Tryptophan is metabolized by microorganisms into various indole derivatives that have been proven to alleviate diseases and promote human health. Lactic acid bacteria (LAB) are a broad microbial concept, some of which have been developed as probiotics ...
Tong Pan, Tong Pan, Zhangming Pei, Zhangming Pei, Zhifeng Fang, Hongchao Wang, Hongchao Wang, Jinlin Zhu, Jinlin Zhu, Hao Zhang, Hao Zhang, Hao Zhang, Hao Zhang, Jianxin Zhao, Jianxin Zhao, Jianxin Zhao, Wei Chen, Wei Chen, Wei Chen, Wenwei Lu, Wenwei Lu, Wenwei Lu, Wenwei Lu, Wenwei Lu   +23 more
doaj   +1 more source

Gut microbiome and metabolic activity in type 1 diabetes: An analysis based on the presence of GADA

Frontiers in Endocrinology, 2022
ObjectiveType 1 diabetes (T1D) progression is affected by circulating glutamic acid decarboxylase antibody (GADA) that persist for many years. This study aimed at investigating whether and how the gut microbiome and its correlated metabolites change in ...
Sihui Luo, Tong Yue, Ziyu Liu, Daizhi Yang, Mengyun Xu, Yu Ding, Weiwei Jiang, Wen Xu, Jinhua Yan, Jianping Weng, Xueying Zheng   +10 more
doaj   +1 more source

The impact of bariatric surgery on serum tryptophan–kynurenine pathway metabolites

Scientific Reports, 2022
This study aims to explore the immediate effects of bariatric surgery on serum tryptophan–kynurenine pathway metabolites in individuals with type 2 diabetes and BMI > 30.
Kai Tai Derek Yeung, Nicholas Penney, Luke Whiley, Hutan Ashrafian, Matthew R. Lewis, Sanjay Purkayastha, Ara Darzi, Elaine Holmes   +7 more
doaj   +1 more source

Tryptophan metabolites profile predict remission with dietary therapy in pediatric Crohn's disease. [PDF]

Therap Adv Gastroenterol
Background: Crohn’s disease (CD) exclusion diet combined with partial enteral nutrition (CDED + PEN) or exclusive enteral nutrition (EEN) is effective in inducing remission in mild-to-moderate pediatric CD. Although CDED + PEN is better tolerated and has
Sigall Boneh R, van der Kruk N, Wine E, Verburgt CM, de Meij TGJ, Löwenberg M, Gecse KB, Wierdsma N, Derikx JPM, de Jonge WJ, D'Haens G, Ghiboub M, Van Limbergen JE.   +12 more
europepmc   +2 more sources

Characterizing the influence of gut microbiota on host tryptophan metabolism with germ-free pigs

Animal Nutrition, 2022
Intestinal microbes are closely associated with host health, depending on metabolic crosstalk between the microbiota and host. Tryptophan metabolism is one of the best examples of metabolic crosstalk between intestinal microbiota and host; however, our ...
Bingnan Liu, Dongming Yu, Jing Sun, Xiaoyan Wu, Zhongquan Xin, Baichuan Deng, Lijuan Fan, Jian Fu, Liangpeng Ge, Wenkai Ren   +9 more
doaj   +1 more source

Peripheral tryptophan and serotonin and kynurenine pathways in major depression: A case-control study

European Psychiatry, 2021
Introduction The tryptophan pathway along with its two branches of metabolism to serotonin and kynurenine seems to be affected in major depression.
R. Colle, C. Verstuyft, D. David, P. Chanson, E. Corruble   +4 more
doaj   +1 more source

Tryptophan metabolism as bridge between gut microbiota and brain in chronic social defeat stress-induced depression mice

Frontiers in Cellular and Infection Microbiology, 2023
BackgroundsGut microbiota plays a critical role in the onset and development of depression, but the underlying molecular mechanisms are unclear. This study was conducted to explore the relationships between gut microbiota and host’s metabolism in ...
Jing Xie, Wen-tao Wu, Jian-jun Chen, Qi Zhong, Dandong Wu, Lingchuan Niu, Sanrong Wang, Yan Zeng, Ying Wang   +8 more
doaj   +1 more source

Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity

Gut Microbes, 2020
Commensal microbiota-dependent tryptophan catabolism within the gastrointestinal tract is known to exert profound effects upon host physiology, including the maintenance of epithelial barrier and immune function.
Fangcong Dong, Fuhua Hao, Iain A. Murray, Philip B. Smith, Imhoi Koo, Alyssa M. Tindall, Penny M. Kris-Etherton, Krishne Gowda, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew   +10 more
doaj   +1 more source