Results 21 to 30 of about 70,579 (241)

LC-MS/MS-Based Profiling of Tryptophan-Related Metabolites in Healthy Plant Foods

Molecules, 2020
Food plants contain hundreds of bioactive phytochemicals arising from different secondary metabolic pathways. Among these, the metabolic route of the amino acid Tryptophan yields a large number of plant natural products with chemically and ...
Sara Vitalini, Michele Dei Cas, Federico Maria Rubino, Ileana Vigentini, Roberto Foschino, Marcello Iriti, Rita Paroni   +6 more
doaj   +1 more source

Tryptophan-centered metabolic alterations coincides with lipid-mediated fungal response to cold stress

Heliyon, 2023
Tryptophan and its derived metabolites have been assumed to play important roles in the development and survival of organisms. However, the links of tryptophan and its derived metabolites to temperature change remained largely cryptic.
Yonghong Chen, Xiaoyu Yang, Longlong Zhang, Qunfu Wu, Shuhong Li, Jianghui Gou, Jiangbo He, Keqin Zhang, Shenghong Li, Xuemei Niu   +9 more
doaj   +1 more source

Tryptophan intake, not always the more the better

Frontiers in Nutrition, 2023
ObjectivesTo investigate the effects of excessive tryptophan intake on the body and the effects of tryptophan metabolism-related aryl hydrocarbon receptor (AhR) pathway in healthy rats and chronic kidney disease rats, to study the adverse effects of ...
Dongmei Hu, Junyi Liu, Wanlin Yu, Chuan Li, Chuan Li, Lihua Huang, Lihua Huang, Wei Mao, Wei Mao, Zhaoyu Lu, Zhaoyu Lu   +10 more
doaj   +1 more source

Gut Microbiota-Derived Tryptophan Metabolites Alleviate Allergic Asthma Inflammation in Ovalbumin-Induced Mice. [PDF]

Foods
Asthma is a prevalent respiratory disease. The present study is designed to determine whether gut microbiota-derived tryptophan metabolites alleviate allergic asthma inflammation in ovalbumin (OVA)-induced mice and explore the effect and potential ...
Wang H, He Y, Dang D, Zhao Y, Zhao J, Lu W.   +5 more
europepmc   +2 more sources

Tryptophan metabolic pathway and neopterin in asthmatic children in clinical practice

Italian Journal of Pediatrics, 2019
Tryptophan metabolic pathway is involved in pathogenic mechanisms of asthma. This study aimed to evaluate tryptophan metabolites and neopterin in a group of asthmatic children. Tryptophan metabolites and neopterin were measured in asthmatic children (121,
Amelia Licari, Dietmar Fuchs, Gianluigi Marseglia, Giorgio Ciprandi   +3 more
doaj   +1 more source

Integrative analysis of the gut microbiota and faecal and serum short-chain fatty acids and tryptophan metabolites in patients with cirrhosis and hepatic encephalopathy. [PDF]

J Transl Med, 2023
Objective The purpose of this study was to describe the changes in the gut microbiome of patients with cirrhosis and hepatic encephalopathy (HE), as well as quantify the variations in short-chain fatty acid (SCFA) and tryptophan metabolite levels in ...
Wang Q, Chen C, Zuo S, Cao K, Li H.
europepmc   +2 more sources

Lung-Gut Microbiota and Tryptophan Metabolites Changes in Neonatal Acute Respiratory Distress Syndrome. [PDF]

J Inflamm Res
Jingli Yang,1– 4 Yu He,1– 5 Qing Ai,1– 4 Chan Liu,1– 4 Qiqi Ruan,1– 4 Yuan Shi1– 4 1Department of Neonatology, Children’s Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2National Clinical Research Center for Child Health
Yang J, He Y, Ai Q, Liu C, Ruan Q, Shi Y.   +5 more
europepmc   +2 more sources

Tryptophan metabolite-regulated Treg responses contribute to attenuation of airway inflammation during specific immunotherapy in a mouse asthma model

Human Vaccines & Immunotherapeutics, 2020
In allergen-specific immunotherapy for asthma, antigens attached to dendritic cells increase the tryptophan metabolism in these cells and alter the Th17/Treg balance in the airways.
Qi Hu, Ling Jin, Jing Zeng, Jinyu Wang, Shimin Zhong, Wenting Fan, Wei Liao   +6 more
doaj   +1 more source

Association between gut microbiome-related metabolites and symptomatic hand osteoarthritis in two independent cohortsResearch in context

EBioMedicine, 2023
Summary: Background: Since gut microbiome dysbiosis can cause inflammatory disorders by affecting host metabolism, we postulate that the gut microbiome and related metabolites could play a role in hand osteoarthritis.
Jie Wei, Zidan Yang, Jiatian Li, Yuqing Zhang, Weiya Zhang, Michael Doherty, Tuo Yang, Yuanheng Yang, Hui Li, Yilun Wang, Ziying Wu, Changjun Li, Guanghua Lei, Chao Zeng   +13 more
doaj   +1 more source

Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production.

PLoS ONE, 2014
The aryl hydrocarbon receptor (AHR) binds to environmental toxicants including synthetic halogenated aromatic hydrocarbons and is involved in a diverse array of biological processes.
Margaret M Lowe, Jeff E Mold, Bittoo Kanwar, Yong Huang, Alexander Louie, Michael P Pollastri, Cuihua Wang, Gautam Patel, Diana G Franks, Jennifer Schlezinger, David H Sherr, Allen E Silverstone, Mark E Hahn, Joseph M McCune   +13 more
doaj   +1 more source