Results 31 to 40 of about 70,579 (241)

Microbiota-mediated skewing of tryptophan catabolism modulates CD4+ T cells in lupus-prone mice

iScience, 2022
Summary: A skewed tryptophan metabolism has been reported in patients with lupus. Here, we investigated the mechanisms by which it occurs in lupus-susceptible mice, and how tryptophan metabolites exacerbate T cell activation.
Josephine Brown, Georges Abboud, Longhuan Ma, Seung-Chul Choi, Nathalie Kanda, Leilani Zeumer-Spataro, Jean Lee, Weidan Peng, Joy Cagmat, Tamas Faludi, Mansour Mohamadzadeh, Timothy Garrett, Laura Mandik-Nayak, Alexander Chervonsky, Andras Perl, Laurence Morel   +15 more
doaj   +1 more source

The Engagement of Cytochrome P450 Enzymes in Tryptophan Metabolism

Metabolites, 2023
Tryptophan is metabolized along three main metabolic pathways, namely the kynurenine, serotonin and indole pathways. The majority of tryptophan is transformed via the kynurenine pathway, catalyzed by tryptophan-2,3-dioxygenase or indoleamine-2,3 ...
Anna Haduch, Ewa Bromek, Wojciech Kuban, Władysława Anna Daniel   +3 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Sophisticated crosstalk of tryptophan-derived metabolites in plant stress responses

Plant Communications
Plants are frequently threatened by diverse stresses that severly impact their health and constrain crop productivity worldwide. Metabolic regulation serves as an important strategy for enhancing plant stress tolerance.
Shuang Wang, Xia Zhang, Dao-Hong Gong, Qiu-Qian Huang, W.M.W.W. Kandegama, Milen I. Georgiev, Yang-Yang Gao, Pan Liao, Ge-Fei Hao   +8 more
doaj   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Distinct Patterns of Tryptophan Maintenance in Tissues during Kynurenine Pathway Activation in Simian Immunodeficiency Virus-Infected Macaques

Frontiers in Immunology, 2016
Induction of the kynurenine pathway (KP) of tryptophan catabolism has been proposed to contribute to T cell dysfunction during human/simian immunodeficiency virus (HIV/SIV) infection via depletion of local tryptophan levels and production of ...
Julia L Drewes, Joshua Croteau, Erin Shirk, Elizabeth L Engle, M. Christine Zink, David Graham   +5 more
doaj   +1 more source

Microbiota-derived tryptophan metabolites indole-3-lactic acid is associated with intestinal ischemia/reperfusion injury via positive regulation of YAP and Nrf2

Journal of Translational Medicine, 2023
Background Lactobacillus has been demonstrated to serve a protective role in intestinal injury. However, the relationship between Lactobacillus murinus (L. murinus)-derived tryptophan metabolites and intestinal ischemia/reperfusion (I/R) injury yet to be
Fang-Ling Zhang, Xiao-Wei Chen, Yi-Fan Wang, Zhen Hu, Wen-Juan Zhang, Bo-Wei Zhou, Peng-Fei Ci, Ke-Xuan Liu   +7 more
doaj   +1 more source

Germanane Quantum Dots Promote Metabolic Reprogramming of Immune Cells Toward Regulatory T Cells and Suppress Inflammation In Vitro and In Vivo

Advanced Functional Materials, EarlyView.
Metabolic changes in immune cells direct the phenotype and function of the host immune system. Smart nanomaterials must target metabolic pathways to direct immune cell fate. This study reports the fabrication and first application of germanane quantum dots (GeHQDs) to modulate inflammation in vitro and in vivo.
Abhay Srivastava, Alireza Rafieerad, Weiang Yan, Keshav Narayan Alagarsamy, Qingdong Guan, Leena Regi Saleth, Michel Aliani, Sanjiv Dhingra   +7 more
wiley   +1 more source

Indole‐3‐Propionic Acid Improves Alveolar Development Impairment via Targeting VAMP8‐mediated SNAREs Complex Formation in Bronchopulmonary Dysplasia

Advanced Science, EarlyView.
This study aims to evaluate the impact of the tryptophan‐derived metabolite indole‐3‐propionic acid (IPA) on lung development and autophagic flux. IPA alleviates hyperoxia‐induced alveolar arrest by promoting autophagosome‐lysosome fusion via inhibition of VAMP8 phosphorylation, which is suggestive of a promising therapeutic target of BPD.
Beibei Wang, Xu Chen, Haowei Xu, Zhiqi Zeng, Keyu Lu, Yu Mao, Qianru Lv, Hui Shi, Song Liu, Xian Shen, Chunyu Yin, Yang Yang, Yan Guo, Xingyun Wang, Rui Cheng   +14 more
wiley   +1 more source

Effects of pharmacological treatment on metabolomic alterations in animal models of depression

Translational Psychiatry, 2022
Numerous studies have investigated metabolite alterations resulting from pharmacological treatment in depression models although few quantitative studies explored metabolites exhibiting constant alterations.
Juncai Pu, Yiyun Liu, Siwen Gui, Lu Tian, Yue Yu, Dongfang Wang, Xiaogang Zhong, Weiyi Chen, Xiaopeng Chen, Yue Chen, Xiang Chen, Xue Gong, Lanxiang Liu, Wenxia Li, Haiyang Wang, Peng Xie   +15 more
doaj   +1 more source