Results 261 to 270 of about 455,075 (302)

Tumor Microenvironment and the Immune Response

Surgical Oncology Clinics of North America, 2007
Without clinical information, accurate follow-up, high-quality sample collection, and preservation, scientific conclusions are only based on theoretical assumptions that are unlikely to lead to clinical breakthroughs. In this article we discuss our understanding of the relationship between cancer cells and the host immune response.
S. Selleri, C. Rumio, M. Sabatino, F. M. Marincola, E. Wang   +4 more
openaire   +2 more sources

Co-dependencies in the tumor immune microenvironment

Oncogene, 2022
Activated oncogenes and disrupted tumor suppressor genes (TSGs) not only endow aspiring cancer cells with new biological capabilities but also influence the composition and function of host cells in the tumor microenvironment (TME). These non-cancer host cells can in turn provide cancer cells with growth support and protection from the anti-tumor ...
Peiwen Chen, Prasenjit Dey
openaire   +2 more sources

Immune checkpoints in the tumor microenvironment

Seminars in Cancer Biology, 2020
Interactions between immune checkpoints (ICs) and their ligands negatively regulate T cell activation pathways involved in physiological immune responses against specific antigens. ICs and their ligands are frequently upregulated in the tumor microenvironment (TME) of various malignancies, and they represent significant barriers for induction of ...
Salman M, Toor, Varun, Sasidharan Nair, Julie, Decock, Eyad, Elkord   +3 more
openaire   +2 more sources

Adaptive Immunity and the Tumor Microenvironment

2020
The adaptive immune response is a 500-million-year-old (the "Big Bang" of Immunology) collective set of rearranged and/or selected receptors capable of recognizing soluble and cell surface molecules or shape (B cells, antibody), endogenous and extracellular peptides presented by Major Histocompatibility (MHC) molecules including Class I and Class II ...
, Han, , Lotze
openaire   +2 more sources

The tumor immune-microenvironment in gastric cancer

Tumori Journal, 2022
Aims and Background: The tumor microenvironment significantly influences malignant behavior and progression. Many components are involved in the tumor microenvironment, including extracellular matrix, stromal cells, immune and inflammatory cells, as well as cytokines that promote tumor development with complex interactions through the exchange of ...
Fujin Fang, Tiantian Zhang, Qiong Li, Xiaowei Chen, Fei Jiang, Xiaobing Shen   +5 more
openaire   +2 more sources

Immune Suppression in the Tumor Microenvironment

Journal of Immunotherapy, 2006
The identification of tumor-expressed antigens that can be recognized by specific T lymphocytes has made it possible both to study the properties of T cells participating in anti-tumor immune responses in patients and also to develop antigen-specific immunotherapies as a treatment modality.
Thomas F, Gajewski, Yuru, Meng, Helena, Harlin   +2 more
openaire   +2 more sources

Immune Cells Within the Tumor Microenvironment

2013
A plethora of intrinsic and extrinsic factors, including communication between tumorigenic cells and infiltrating immune cells, fibroblasts, epithelial cells, vascular and lymphatic endothelial cells, cytokines and chemokines, constitute the tumor microenvironment.
ZOLLO, MASSIMO, SPANO, DANIELA
openaire   +3 more sources

Spatial landscape of the tumor immune microenvironment

Trends in Cancer, 2023
Two recent studies published in Nature by Karimi et al. and Sorin et al. applied multiplexed imaging mass cytometry (IMC) to characterize the single-cell tumor immune landscapes covering millions of cells in brain tumors and lung adenocarcinomas (LUAD).
Yamei, Chen, Yuan, Liu, Leng, Han
openaire   +2 more sources

Exosomes Function in Tumor Immune Microenvironment

2018
Immune cells and mesenchymal stem/stromal cells are the major cellular components in tumor microenvironment that actively migrate to tumor sites by sensing "signals" released from tumor cells. Together with other stromal cells, they form the soil for malignant cell progression.
Yin, Huang, Keli, Liu, Qing, Li, Yikun, Yao, Ying, Wang   +4 more
openaire   +2 more sources

Innate immune cells in the tumor microenvironment

Cancer Cell, 2021
The tumor immune microenvironment (TIME) is a complex ecosystem that contains adaptive and innate immune cells that have tumor-promoting and anti-tumor effects. There is still much to learn about the diversity, plasticity, and functions of innate immune cells in the TIME and their roles in determining the response to immunotherapies.
Li, Ming O, Wolf, Natalie, Raulet, David H, Akkari, Leila, Pittet, Mikaël, Rodriguez, Paulo C, Kaplan, Rosandra N, Munitz, Ariel, Zhang, Zemin, Cheng, Sijin, Bhardwaj, Nina   +10 more
openaire   +3 more sources