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Functional analysis of TWIST1 domains regulating smooth muscle cell phenotype [PDF]
Frontiers in Cardiovascular MedicineIntroductionTWIST1, a bHLH transcription factor, regulates mesenchymal specification, differentiation, proliferation and migration during development and in diseases such as cancer. More recently, genome-wide association studies have identified TWIST1 as
Danielle C. M. Dy +7 more
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TWIST1 drives endothelial-to-mesenchymal-transition to stabilize atherosclerotic plaques [PDF]
Nature CommunicationsRupture of unstable atherosclerotic plaques is a major cause of mortality. Endothelial-to-mesenchymal transition associates with advanced atherosclerotic plaques and contributes to plaque progression.
Blanca Tardajos Ayllon +18 more
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Effects of Thyroxine Exposure on Osteogenesis in Mouse Calvarial Pre-Osteoblasts [PDF]
, 2013 The incidence of craniosynostosis is one in every 1,800-2500 births. The gene-environment model proposes that if a genetic predisposition is coupled with environmental exposures, the effects can be multiplicative resulting in severely abnormal phenotypes.
A Mansukhani +58 more
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Hypertension in Pregnancy, 2021 Purpose This study is aimed to elucidate the molecular mechanism of lncRNA SNHG7 on pre-eclampsia (PE). Methods The expression of SNHG7, miR-214-5p and TWIST1 in PE placental tissues was detected by qRT-PCR.
Yongping Wang, Zhihui Zhang
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Androgen up-regulation of Twist1 gene expression is mediated by ETV1 [PDF]
PeerJ, 2020 Twist1, a basic helix-loop-helix transcription factor that regulates a number of genes involved in epithelial-to-mesenchymal transition (EMT), is upregulated in prostate cancer. Androgen regulation of Twist1 has been reported in a previous study. However,
Prabesh Khatiwada +4 more
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CBX7 regulates metastasis of basal-like breast cancer through Twist1/EphA2 pathway
Translational Oncology, 2022 Background: Basal-like breast cancer (BLBC) is an important subtype of breast cancer. Twist1 is a key transcription factor in BLBC metastasis, which serves a key role in tumorigenesis.
Tao Dai +3 more
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Frontiers in Oncology, 2020 The epithelial-mesenchymal transition (EMT) is a vital step in osteosarcoma (OS) progression toward metastasis, but the specific molecular events governing this process are incompletely characterized, with miRNAs having increasingly been found to ...
Shu-tao Zhu +4 more
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FEBS Open Bio, 2021 TWIST1 is an important basic helix‐loop‐helix protein linked to multiple physiological and pathological processes. Although TWIST1 is believed to be involved in vascular pathogenesis, its effects on homeostasis of smooth muscle cells (SMCs) remain poorly
Jing Zhang +7 more
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Regulatory Role of the Transcription Factor Twist1 in Cancer-Associated Muscle Cachexia
Frontiers in Physiology, 2020 Muscle cachexia is a catabolic response, usually takes place in various fatal diseases, such as sepsis, burn injury, and chronic kidney disease. Muscle cachexia is also a common co-morbidity seen in the vast majority of advanced cancer patients, often ...
Mohammed S. Razzaque, Azeddine Atfi
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Twist1 directly regulates genes that promote cell proliferation and migration in developing heart valves. [PDF]
PLoS ONE, 2011 Twist1, a basic helix-loop-helix transcription factor, is expressed in mesenchymal precursor populations during embryogenesis and in metastatic cancer cells.
Mary P Lee, Katherine E Yutzey
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