Results 11 to 20 of about 28,841 (200)
Obesity Inhibits Angiogenesis Through TWIST1-SLIT2 Signaling [PDF]
Frontiers in Cell and Developmental Biology, 2021 Angiogenesis is required for functional adipose tissue maintenance, remodeling, and expansion. Physiologically balanced adipogenesis and angiogenesis are inhibited in subcutaneous adipose tissue in obese humans.
Tendai Hunyenyiwa +9 more
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Twist1 Suppresses Cementoblast Differentiation [PDF]
Dentistry Journal, 2018 The transcription factor Twist1 is known to be closely associated with the formation of bone by mesenchymal stem cells and osteoblasts; however, the role of Twist1 in cementogenesis has not yet been determined.
Jung-Sun Moon +5 more
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Neoplasia: An International Journal for Oncology Research, 2016 The TWIST1 embryonic transcription factor displays biphasic functions during the course of carcinogenesis. It facilitates the escape of cells from oncogene-induced fail-safe programs (senescence, apoptosis) and their consequent neoplastic transformation.
Laurent Jacqueroud +10 more
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Methylation of the TWIST1 Promoter, TWIST1 mRNA Levels, and Immunohistochemical Expression of TWIST1 in Breast Cancer [PDF]
Cancer Epidemiology, Biomarkers & Prevention, 2008 Abstract TWIST1, an antiapoptotic and prometastatic transcription factor, is overexpressed in many epithelial cancers including breast. Only little is known regarding the regulation of TWIST1 in these cancers. Recently, an increase in the TWIST1 promoter methylation has been shown in breast cancers.
Eelke H, Gort +6 more
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Twist1-Induced Epithelial Dissemination Requires Prkd1 Signaling [PDF]
Cancer Research, 2020 Abstract Dissemination is an essential early step in metastasis but its molecular basis remains incompletely understood. To define the essential targetable effectors of this process, we developed a 3D mammary epithelial culture model, in which dissemination is induced by overexpression of the ...
Dan Georgess +8 more
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Endothelial TWIST1 Promotes Pathological Ocular Angiogenesis [PDF]
Investigative Ophthalmology & Visual Science, 2014 Pathological neovessel formation impacts many blinding vascular eye diseases. Identification of molecular signatures distinguishing pathological neovascularization from normal quiescent vessels is critical for developing new interventions. Twist-related protein 1 (TWIST1) is a transcription factor important in tumor and pulmonary angiogenesis.
Jie, Li +10 more
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LncRNA-TWIST1 Promoted Osteogenic Differentiation Both in PPDLSCs and in HPDLSCs by Inhibiting TWIST1 Expression [PDF]
BioMed Research International, 2019 HPDLSCs derived from periodontal ligament tissues contribute to tooth development and tissue regeneration. Exploring the effects of long noncoding RNAs (lncRNAs) in the process of osteogenic differentiation of periodontal ligament stem cells would provide novel therapeutic strategies for tissue regeneration.
Yuerong Xu +5 more
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miR-151-3p Targets TWIST1 to Repress Migration of Human Breast Cancer Cells. [PDF]
PLoS ONE, 2016 TWIST1 is a highly conserved basic helix-loop-helix transcription factor that contributes to cancer metastasis by promoting an epithelial-mesenchymal transition and repressing E-cadherin gene expression in breast cancer.
Ting-Chih Yeh +7 more
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Unraveling the transcriptional regulation of TWIST1 in limb development. [PDF]
PLoS Genetics, 2018 The transcription factor TWIST1 plays a vital role in mesoderm development, particularly in limb and craniofacial formation. Accordingly, haploinsufficiency of TWIST1 can cause limb and craniofacial malformations as part of Saethre-Chotzen syndrome ...
Naama Hirsch +9 more
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Communications Biology, 2022 TWIST1 and TWIST2 were found to display an opposed expression pattern, with TWIST1 associated with poor survival and TWIST2 with good prognosis. Functional studies revealed that TWIST1 promotes both primary and metastatic neuroblastoma (NB) tumor growth.
Maria-Vittoria Sepporta +11 more
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