Results 31 to 40 of about 28,841 (200)
miR-9-5p Exerts a Dual Role in Cervical Cancer and Targets Transcription Factor TWIST1
Cells, 2019 Squamous cell carcinoma (SCC) and adenocarcinoma (AC) represent the major cervical cancer histotypes. Both histotypes are caused by infection with high-risk HPV (hrHPV) and are associated with deregulated microRNA expression.
Iris Babion +5 more
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Twist1 suppresses senescence programs and thereby accelerates and maintains mutant Kras-induced lung tumorigenesis. [PDF]
PLoS Genetics, 2012 KRAS mutant lung cancers are generally refractory to chemotherapy as well targeted agents. To date, the identification of drugs to therapeutically inhibit K-RAS have been unsuccessful, suggesting that other approaches are required. We demonstrate in both
Phuoc T Tran +19 more
doaj +1 more source
Emerging role of Twist1 in fibrotic diseases [PDF]
Journal of Cellular and Molecular Medicine, 2018 AbstractEpithelial–mesenchymal transition (EMT) is a pathological process that occurs in a variety of diseases, including organ fibrosis. Twist1, a basic helix–loop–helix transcription factor, is involved in EMT and plays significant roles in various fibrotic diseases.
Xiaoxuan Ning +4 more
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PLoS ONE, 2015 Twist1 overexpression is frequently observed in various cancers including gastric cancer (GC). Although DNA methylation of the Twist1 gene has been reported in cancer cells, the mechanisms underlying transcriptional activation remain uncertain.
Ayuna Sakamoto +5 more
doaj +1 more source
BMC Cancer, 2022 Background Esophageal squamous cell carcinoma (ESCC) is one of the deadliest cancers worldwide. Overexpression of EMT master transcription factors can promote differentiated cells to undergo cancer reprogramming processes and acquire a stem cell-like ...
Sima Ardalan Khales +3 more
doaj +1 more source
Twist1 promotes radioresistance in nasopharyngeal carcinoma
Oncotarget, 2016 With the development of advanced imaging and radiation technologies, radiotherapy has been employed as the principal treatment approach for nasopharyngeal carcinoma (NPC). So far, a number of patients still suffer from the failure of this treatment due to the acquired radioresistance, but the underlying mechanisms are still poorly defined.
Zhang, Linli +9 more
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TWIST1 homodimers and heterodimers orchestrate lineage-specific differentiation [PDF]
Molecular and Cellular Biology, 2019 AbstractThe extensive array of bHLH transcription factors and their combinations as dimers underpin the diversity of molecular function required for cell type specification during embryogenesis. The bHLH factor TWIST1 plays pleiotropic roles during development. However, which combinations of TWIST1 dimers are involved and what impact each dimer imposes
Fan, Xiaochen +8 more
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mSphere, 2020 Human papillomaviruses (HPVs) are causative agents in around 5% of all cancers, including cervical and oropharyngeal. A feature of HPV cancers is their better clinical outcome compared with non-HPV anatomical counterparts.
Christian T. Fontan +7 more
doaj +1 more source
BMI1 and TWIST1 Downregulated mRNA Expression in Basal Cell Carcinoma [PDF]
, 2014 Background: BMI1, TWIST1 and SNAI2/SLUG have been implicated in aggressive behavior of squamous cell carcinoma (SCC) and melanoma and BMI1 expression could identify subtypes of Merkel cell carcinoma (MCC).
Fathi, Hamidreza. +9 more
core +1 more source
TGIF1-Twist1 axis in pancreatic ductal adenocarcinoma
Computational and Structural Biotechnology Journal, 2020 TG-interacting factor 1 (TGIF1) exerts inhibitory effects on transforming growth factor-beta (TGF-β) signaling by suppressing Smad signaling pathway at multiple levels. TGIF1 activity is important for normal embryogenesis and organogenesis, yet its dysregulation can culminate in tumorigenesis. For instance, increased expression of TGIF1 correlates with
Mohammed S. Razzaque, Azeddine Atfi
openaire +3 more sources