Results 41 to 50 of about 28,841 (200)
Interference of p53:Twist1 interaction through competing nanobodies
International Journal of Biological Macromolecules, 2022 Twist1 promote the bypass of p53 response by interacting with p53 and facilitating its MDM2-mediated degradation. We reasoned that reagents able to interfere with the p53:Twist1 complex might alleviate Twist1 inhibitory effect over p53, thus representing potential therapeutic tools in p53 wild type tumors. From a pre-immune library of llama nanobodies (
D'Agostino S. +8 more
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MiR-337-3p Promotes Adipocyte Browning by Inhibiting TWIST1
Cells, 2020 The prevalence of metabolic syndrome (MetS) and obesity is an alarming health issue worldwide. Obesity is characterized by an excessive accumulation of white adipose tissue (WAT), and it is associated with diminished brown adipose tissue (BAT) activity ...
Indira G.C. Vonhögen +8 more
doaj +1 more source
Twist1-Induced Invadopodia Formation Promotes Tumor Metastasis [PDF]
Cancer Cell, 2011 The Twist1 transcription factor is known to promote tumor metastasis and induce Epithelial-Mesenchymal Transition (EMT). Here, we report that Twist1 is capable of promoting the formation of invadopodia, specialized membrane protrusions for extracellular matrix degradation.
Eckert, Mark A. +6 more
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JCI Insight, 2021 The transcription factor Twist1 regulates several processes that could impact kidney disease progression, including epithelial cell differentiation and inflammatory cytokine induction.
Jiafa Ren +9 more
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TWIST1 is expressed in colorectal carcinomas and predicts patient survival. [PDF]
PLoS ONE, 2011 TWIST1 is a transcription factor that belongs to the family of basic helix-loop-helix proteins involved in epithelial-to-mesenchymal transition and invasion processes.
Irene Gomez +11 more
doaj +1 more source
FOXD3 modulates migration through direct transcriptional repression of TWIST1 in melanoma. [PDF]
, 2014 UNLABELLED: The neural crest is a multipotent, highly migratory cell population that gives rise to diverse cell types, including melanocytes. Factors regulating the development of the neural crest and emigration of its cells are likely to influence ...
Abel, E V +3 more
core +1 more source
Abstract 1969: PKCα-induced Twist1 phosphorylation is a novel regulator of Twist1 stabilization
Cancer Research, 2017 Abstract Background: Epithelial - mesenchymal transition (EMT) is a pre-requisite for cancer metastasis. Twist-1 is a transcription factor with a central role in the process of EMT and therefore metastasis formation.
Roslyn Tedja +8 more
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TWIST1 Plays a Pleiotropic Role in Determining the Anaplastic Thyroid Cancer Phenotype [PDF]
, 2011 10 páginas, 5 figuras, 1 tabla.-- et al.[Context]:Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human tumors; it is characterized by chemoresistance, local invasion, and distant metastases. ATC is invariably fatal.
García-Rostan, Ginesa, Salerno, Paolo
core +1 more source
Protein kinase Cα–mediated phosphorylation of Twist1 at Ser-144 prevents Twist1 ubiquitination and stabilizes it [PDF]
Journal of Biological Chemistry, 2019 Twist1 is a basic helix-loop-helix transcription factor that plays a key role in embryonic development, and its expression is down-regulated in adult cells. However, Twist1 is highly expressed during cancer development, conferring a proliferative, migratory, and invasive phenotype to malignant cells.
Roslyn Tedja +9 more
openaire +2 more sources
Twist1: A Double-Edged Sword in Kidney Diseases [PDF]
Kidney Diseases, 2020 <b><i>Background:</i></b> Twist1 is a basic helix-loop-helix domain containing transcription factor that regulates cell differentiation, migration, proliferation, survival, and inflammatory responses by transcriptionally regulating a wide range of downstream target genes.
Jiafa, Ren, Steven D, Crowley
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