High TWIST1 mRNA expression is associated with poor prognosis in lymph node-negative and estrogen receptor-positive human breast cancer and is co-expressed with stromal as well as ECM related genes [PDF]
, 2012 Introduction: The TWIST homolog 1 (TWIST1) is a transcription factor that induces epithelial to mesenchymal transition (EMT), a key process in metastasis. The purpose of this study was to investigate whether TWIST1 expression predicts disease progression
A Bergamaschi +43 more
core +3 more sources
TRIM29 Suppresses TWIST1 and Invasive Breast Cancer Behavior [PDF]
Cancer Research, 2014 Abstract TRIM29 (ATDC) exhibits a contextual function in cancer, but seems to exert a tumor-suppressor role in breast cancer. Here, we show that TRIM29 is often silenced in primary breast tumors and cultured tumor cells as a result of aberrant gene hypermethylation.
Ai, Lingbao +10 more
openaire +3 more sources
The speckle-type POZ protein (SPOP) inhibits breast cancer malignancy by destabilizing TWIST1
Cell Death Discovery, 2022 Epithelial-mesenchymal transition (EMT) inducing transcription factor TWIST1 plays a vital role in cancer metastasis. How the tumor-suppressive E3 ligase, speckle-type POZ protein (SPOP), regulates TWIST1 in breast cancer remains unknown.
Chunli Wei +8 more
doaj +1 more source
Negative regulation of the androgen receptor gene through a primate specific androgen response element present in the 5' UTR [PDF]
, 2014 Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
Hay, Colin W +5 more
core +2 more sources
TWIST1 controls cellular senescence and energy metabolism in mesenchymal stem cells [PDF]
European Cells & Materials, 2021 Mesenchymal stem cells (MSCs) are promising cells for regenerative medicine therapies because they can differentiate towards multiple cell lineages. However, the occurrence of cellular senescence and the acquiring of the senescence-associated secretory ...
C Voskamp +6 more
doaj +1 more source
Angewandte Chemie, EarlyView.We herein report the synthesis of a new heteroheptacene derivative with periodically incorporated six boron atoms. This compound exhibits dual fluorescence attributed to two interconvertible conformers that result from a delicate balance between the extended π‐system and the steric demand of bulky aryl groups attached to the boron centers.
Takeshi Yokochi +6 more
wiley +2 more sources
Inhibition of EZH2 Promotes Human Embryonic Stem Cell Differentiation into Mesoderm by Reducing H3K27me3. [PDF]
, 2017 Mesoderm derived from human embryonic stem cells (hESCs) is a major source of the mesenchymal stem/stromal cells (MSCs) that can differentiate into osteoblasts and chondrocytes for tissue regeneration.
Aghaloo, Tara +6 more
core +2 more sources
Phosphorylation of Serine 68 of Twist1 by MAPKs Stabilizes Twist1 Protein and Promotes Breast Cancer Cell Invasiveness [PDF]
Cancer Research, 2011 Abstract Twist1, a basic helix–loop–helix transcription factor, promotes breast tumor cell epithelial–mesenchymal transition (EMT), invasiveness, and metastasis. However, the mechanisms responsible for regulating Twist1 stability are unknown in these cells. We identified the serine 68 (Ser 68) as a major phosphorylation site of Twist1
Jun, Hong +7 more
openaire +2 more sources
Mutant CFTR Drives TWIST1 mediated epithelial–mesenchymal transition [PDF]
Cell Death & Disease, 2020 AbstractCystic fibrosis (CF) is a monogenetic disease resulting from mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene encoding an anion channel. Recent evidence indicates that CFTR plays a role in other cellular processes, namely in development, cellular differentiation and wound healing.
Margarida C. Quaresma +8 more
openaire +2 more sources
Eliminating mesothelioma by AAV-vectored, PD1-based vaccination in the tumor microenvironment
Molecular Therapy: Oncolytics, 2021 The potency of cancer vaccines is often compromised by a variety of immunoinhibitory mechanisms, including stimulation of the programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) immune checkpoint pathway. Here, to overcome inhibition,
Zhiwu Tan +4 more
doaj +1 more source