Results 61 to 70 of about 28,841 (200)

Studies on novel interactors in human adipose tissue [PDF]

, 2011
Obesity is associated with a mild inflammation and altered protein secretion in adipose tissue. These changes have been suggested to contribute to the development of obesity-associated disorders including, insulin resistance, dyslipidemia, type 2 ...
Pettersson, Amanda T.
core   +1 more source

GATA4-Twist1 Signalling in Disturbed Flow-Induced Atherosclerosis [PDF]

Cardiovascular Drugs and Therapy, 2019
Endothelial cell (EC) dysfunction (enhanced inflammation, proliferation and permeability) is the initial trigger for atherosclerosis. Atherosclerosis shows preferential development near branches and bends exposed to disturbed blood flow. By contrast, sites that are exposed to non-disturbed blood flow are atheroprotected.
Mahmoud, M., Souilhol, C., Serbanovic-Canic, J., Evans, P.   +3 more
openaire   +2 more sources

The basic helix loop helix transcription factor twist1 is a novel regulator of ATF4 in osteoblasts [PDF]

, 2012
Parathyroid hormone (PTH) is an essential regulator of endochondral bone formation and an important anabolic agent for the reversal of bone loss. PTH mediates its functions in part by regulating binding of the bone‐related activating transcription factor
Ardura, Bellido, Bialek, Boudreaux, Burgess, Chaudhary, Chen, Chen, Connerney, Danciu, Datta, Ducy, Ducy, Ducy, Ducy, Frendo, Gardella, Iida-Klein, Jiang, Jilka, Komori, Krishnan, Li, Liao, Makarova, McCabe, McCauley, Miao, Muir, Mundlos, Nakashima, Pettway, Schmidt, Sosic, Suzuki, Wang, Xiao, Yang, Yang, Yu, Yu, Yu   +41 more
core   +1 more source

The Wnt-inducible Transcription Factor Twist1 Inhibits Chondrogenesis [PDF]

Journal of Biological Chemistry, 2006
Wnt signaling is essential for many developmental processes, including skeletogenesis. To investigate the effects of Wnt signaling during skeletogenesis we studied the effects of Wnt on cultured chondrocytic cells and differentiating limb-bud mesenchyme. We showed that Wnt3a strongly repressed chondrogenesis and chondrocyte gene expression.
Martina I, Reinhold, Ravi M, Kapadia, Zhixiang, Liao, Michael C, Naski   +3 more
openaire   +2 more sources

PTBP3 promotes tumorigenesis of glioblastoma by stabilizing Twist1

Translational Oncology, 2022
Abstract Glioblastoma (GBM) is the most common malignancy tumor of central nervous system. PTBP3 was closely associated with the development of tumor. However, the function and mechanism of PTBP3 in GBM is little known. We found that PTBP3 was upregulated in GBM, and higher expression of PTBP3 corrected with the poor survival of GBM patients ...
Peng Xie, Yueqing Zhang, Rui Chen, Jinyu Zheng, Gang Cui   +4 more
openaire   +3 more sources

Deciphering the interaction between Twist1 and PPARγ during adipocyte differentiation

Cell Death and Disease, 2023
Obesity, a worldwide epidemic in recent years, is mainly due to the uncontrolled development of adipose tissues, which includes adipocyte hypertrophy and hyperplasia. Adipocyte differentiation is a process involving multiple transcription factor cascades,
Leilei Sun, Shaoping Ji, Xuan Xie, Lei Si, Shaohao Liu, Yao Lin, Yahui Wang, Zhenhua Song, Na Fang, Yang An, Jian Yang   +10 more
doaj   +1 more source

Absolute quantitation of DNA methylation of 28 candidate genes in prostate cancer using pyrosequencing [PDF]

, 2011
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Aberrant DNA methylation plays a pivotal
Beltran, L, Berney, DM, Brentnall, AR, Cuzick, J, Kim, DC, Kudahetti, SC, Lorincz, AT, Lu, YJ, Mao, XY, Shaw, GL, Thorat, MA, Vasiljevic, N, Wu, KQ, Xue, LY, Yu, YW   +14 more
core   +2 more sources

TWIST1 Promoter Methylation in Primary Colorectal Carcinoma

Pathology & Oncology Research, 2011
TWIST1 gene, a transcription factor that belongs to the family of basic helix-loop-helix proteins, has been related to tumor progression and metastasis in different cancers. The aim of our study was to investigate TWIST1 promoter methylation in patients with primary colorectal carcinoma and determine its correlation with prognostic factors and disease ...
Rúbia D, Ruppenthal, Carmela, Nicolini, Antonio Fabiano Ferreira, Filho, Rosalva, Meurer, Andréa P, Damin, Adriana, Rohe, Cláudio O P, Alexandre, Daniel C, Damin   +7 more
openaire   +2 more sources

Twist1 enhances hypoxia induced radioresistance in cervical cancer cells by promoting nuclear EGFR localization

, 2017
Twist1 is a crucial transcription factor that regulates epithelial mesenchymal transition and involves in metastasis. Recent evidence suggests that Twist1 plays important role in hypoxia-induced radioresistance, but the underlying mechanism remains ...
Gong, Chen, Li, Yang, Nie, Xin, Qiu, Hong, Wang, Yihua, Wu, Hua, Xiong, Hua, Xiong, Huihua, Yang, Lin, Zhang, Jing, Zhang, Peng, Zhuang, Liang, Zou, Yanmei   +12 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source