Antimicrobial Resistance: Two-Component Regulatory Systems and Multidrug Efflux Pumps [PDF]
Antibiotics, 2023 The number of multidrug-resistant bacteria is rapidly spreading worldwide. Among the various mechanisms determining resistance to antimicrobial agents, multidrug efflux pumps play a noteworthy role because they export extraneous and noxious substrates ...
Giuseppe Valerio De Gaetano +4 more
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Predicted Functional and Structural Diversity of Receiver Domains in Fungal Two-Component Regulatory Systems [PDF]
mSphere, 2021 Fungal two-component regulatory systems incorporate receiver domains into hybrid histidine kinases (HHKs) and response regulators. We constructed a nonredundant database of 670 fungal receiver domain sequences from 51 species sampled from nine fungal ...
Robert B. Bourret +2 more
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ARR22 overexpression can suppress plant Two-Component Regulatory Systems. [PDF]
PLoS ONE, 2019 In plants, several developmental processes are co-coordinated by cytokinins via phosphorylation dependent processes of the Two-Component System (TCS).
Niklas Wallmeroth +6 more
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Progress Overview of Bacterial Two-Component Regulatory Systems as Potential Targets for Antimicrobial Chemotherapy [PDF]
Antibiotics, 2020 Bacteria adapt to changes in their environment using a mechanism known as the two-component regulatory system (TCS) (also called “two-component signal transduction system” or “two-component system”).
Hidetada Hirakawa +3 more
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Two-component regulatory systems in Helicobacter pylori and Campylobacter jejuni: Attractive targets for novel antibacterial drugs [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 Two-component regulatory systems (TCRS) are ubiquitous signal transduction mechanisms evolved by bacteria for sensing and adapting to the constant changes that occur in their environment.
Javier Casado +8 more
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Pneumococcal Metabolic Adaptation and Colonization Are Regulated by the Two-Component Regulatory System 08 [PDF]
mSphere, 2018 Streptococcus pneumoniae two-component regulatory systems (TCS) enable adaptation and ensure its maintenance in host environments. This study deciphers the impact of TCS08 on pneumococcal gene expression and its role in metabolic and pathophysiological ...
Alejandro Gómez-Mejia +12 more
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In Vivo Role of Two-Component Regulatory Systems in Models of Urinary Tract Infections [PDF]
Pathogens, 2023 Two-component signaling systems (TCSs) are finely regulated mechanisms by which bacteria adapt to environmental conditions by modifying the expression of target genes. In bacterial pathogenesis, TCSs play important roles in modulating adhesion to mucosal
Giuseppe Valerio De Gaetano +4 more
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Regulation of pneumococcal epigenetic and colony phases by multiple two-component regulatory systems. [PDF]
PLoS Pathogens, 2020 Streptococcus pneumoniae is well known for phase variation between opaque (O) and transparent (T) colonies within clonal populations. While the O variant is specialized in invasive infection (with a thicker capsule and higher resistance to host clearance)
Juanjuan Wang +5 more
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Environmental instability reduces shock resistance by enriching specialist taxa with distinct two component regulatory systems [PDF]
npj Biofilms and MicrobiomesDifferent microbial communities are impacted disproportionately by environmental disturbances. The degree to which a community can remain unchanged under a disturbance is referred to as resistance1.
Simon Mills +2 more
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Cross-regulation and cross-talk of conserved and accessory two-component regulatory systems orchestrate Pseudomonas copper resistance. [PDF]
PLoS GeneticsBacteria use diverse strategies and molecular machinery to maintain copper homeostasis and to cope with its toxic effects. Some genetic elements providing copper resistance are acquired by horizontal gene transfer; however, little is known about how they
Sylvie Elsen, Victor Simon, Ina Attrée
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