Results 21 to 30 of about 407,697 (279)
Expression Analysis of the Pseudomonas aeruginosa AlgZR Two-Component Regulatory System [PDF]
Journal of Bacteriology, 2015 ABSTRACT Pseudomonas aeruginosa virulence components are subject to complex regulatory control primarily through two-component regulatory systems that allow for sensing and responding to environmental stimuli. In this study, the expression and regulation of the P. aeruginosa AlgZR two-component
Pritchett, Christopher L. +6 more
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Feedback Control of Two-Component Regulatory Systems. [PDF]
Annu Rev Microbiol, 2016 Two-component systems are a dominant form of bacterial signal transduction. The prototypical two-component system consists of a sensor that responds to a specific input(s) by modifying the output of a cognate regulator. Because the output of a two-component system is the amount of phosphorylated regulator, feedback mechanisms may alter the amount of ...
Groisman EA.
europepmc +4 more sources
Sensor domains of two-component regulatory systems. [PDF]
Curr Opin Microbiol, 2010 Two-component systems regulate crucial cellular processes in microorganisms, and each comprises a homodimeric histidine kinase receptor and a cytoplasmic response regulator. Histidine kinases, often membrane associated, detect environmental input at sensor domains and propagate resulting signals to catalytic cytoplasmic transmitter domains.
Cheung J, Hendrickson WA.
europepmc +4 more sources
Signal integration in bacterial two-component regulatory systems. [PDF]
Genes Dev, 2008 Two-component systems (TCSs) and phosphorelays are key mediators of bacterial signal transduction. The signals activating these systems promote the phosphorylated state of a response regulator, which is generally the form that carries out specific functions such as binding to DNA and catalysis of biochemical reactions.
Mitrophanov AY, Groisman EA.
europepmc +4 more sources
Evolution towards Virulence in a
mBio, 2021 Bacteria in the Burkholderia cepacia complex (BCC) are significant pathogens for people with cystic fibrosis (CF) and are often extensively antibiotic resistant.
Matthew M. Schaefers +8 more
doaj +1 more source
Microbiology Spectrum, 2023 Bacterial two-component systems are crucial features of bacterial pathogens such as methicillin-resistant Staphylococcus aureus to overcome environmental and antimicrobial stresses by activating regulons to interfere with the bactericidal mechanisms ...
Junho Cho +3 more
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mBio, 2023 Gram-negative facultative anaerobes often cause bacteremia, a systemic infection associated with severe clinical outcomes. ArcAB, a two-component regulatory system that represses aerobic respiration, is a key mediator of metabolic adaptation for such ...
Aric N. Brown +4 more
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The Role and Regulatory Network of the CiaRH Two-Component System in Streptococcal Species [PDF]
Frontiers in Microbiology, 2021 Pathogenic streptococcal species are responsible for a broad spectrum of human diseases ranging from non-invasive and localized infections to more aggressive and life-threatening diseases, which cause great economic losses worldwide. Streptococci possess a dozen two-component systems (TCSs) that play important roles in the response to different ...
Li-Yuan He +4 more
openaire +3 more sources
mSphere, 2020 Two-component systems control periplasmic Cu+ homeostasis in Gram-negative bacteria. In characterized systems such as Escherichia coli CusRS, upon Cu+ binding to the periplasmic sensing region of CusS, a cytoplasmic phosphotransfer domain of the sensor ...
Lorena Novoa-Aponte +3 more
doaj +1 more source
Phosphate sink containing two-component signaling systems as tunable threshold devices [PDF]
, 2014 Synthetic biology aims to design de novo biological systems and reengineer existing ones. These efforts have mostly focused on transcriptional circuits, with reengineering of signaling circuits hampered by limited understanding of their systems dynamics ...
Elisenda Feliu (481165) +21 more
core +1 more source