Results 11 to 20 of about 407,697 (279)

Interplay between Two-Component Regulatory Systems Is Involved in Control of Cupriavidus metallidurans Metal Resistance Genes. [PDF]

J Bacteriol, 2023
Metal resistance of Cupriavidus metallidurans is based on determinants that were acquired in the past by horizontal gene transfer during evolution. Some of these determinants encode transmembrane metal efflux systems. Expression of most of the respective
Große C, Scherer J, Schleuder G, Nies DH.   +3 more
europepmc   +5 more sources

A Radical Reimagining of Fungal Two-Component Regulatory Systems. [PDF]

Trends Microbiol, 2021
Bacterial two-component regulatory systems (TCSs) mediate signal transduction by transferring phosphoryl groups between sensor kinase and response regulator proteins, sometimes using intermediary histidine-phosphotransferase (Hpt) domains to form multistep phosphorelays.
Bourret RB, Kennedy EN, Foster CA, Sepúlveda VE, Goldman WE.   +4 more
europepmc   +4 more sources

Roles of two-component regulatory systems in antibiotic resistance. [PDF]

Future Microbiol, 2019
Two-component regulatory systems (TCSs) are a major mechanism by which bacteria sense and respond to changes in their environment. TCSs typically consist of two proteins that bring about major regulation of the cell genome through coordinated action mediated by phosphorylation.
Tierney AR, Rather PN.
europepmc   +5 more sources

Two Component Regulatory Systems and Antibiotic Resistance in Gram-Negative Pathogens. [PDF]

Int J Mol Sci, 2019
Gram-negative pathogens such as Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa are the leading cause of nosocomial infections throughout the world. One commonality shared among these pathogens is their ubiquitous presence, robust host-colonization and most importantly, resistance to antibiotics.
Bhagirath AY, Li Y, Patidar R, Yerex K, Ma X, Kumar A, Duan K.   +6 more
europepmc   +5 more sources

Regulatory dynamics of standard two-component systems in bacteria [PDF]

Journal of Theoretical Biology, 2010
Here, we study 14 two-component systems in Escherichia coli, which have been experimentally characterized with respect to their transcriptional regulation and their perceived signal. Given that the activity of these sensory units is connected to the rest of the transcriptional network, we first classify them as autonomous, semiautonomous or dependent ...
Luna, Beatriz, Ugalde, Edgardo, Martínez-antonio, Agustino   +2 more
openaire   +5 more sources

Proteolysis and multimerization regulate signaling along the two-component regulatory system AdeRS [PDF]

iScience, 2021
Summary: Bacterial two-component regulatory systems are ubiquitous environment-sensing signal transducers involved in pathogenesis and antibiotic resistance.
Zhenlin Ouyang, Fang Zheng, Li Zhu, Jan Felix, Di Wu, Ke Wu, Irina Gutsche, Yi Wu, Peter M. Hwang, Junjun She, Yurong Wen   +10 more
doaj   +2 more sources

Drug inhibition of bacterial two-component regulatory systems

Zdorovʹe Rebenka, 2018
There are several ways to adapt and increase the chances of survival of microorganisms. Specific systems involved in the recognition of external changes and the organization of the corresponding reaction of the microorganism are called bacterial sensory ...
А.Е. Abaturov, Т.А. Kryuchko
doaj   +2 more sources

Autoamplification of a Two-Component Regulatory System Results in “Learning” Behavior [PDF]

Journal of Bacteriology, 2001
ABSTRACT We have tested the hypothesis that the autoamplification of two-component regulatory systems results in “learning” behavior, i.e., that bacteria respond faster or more extensively to a signal when a similar signal has been perceived in the past.
Hoffer, S.M., Westerhoff, H.V., Hellingwerf, K.J., Postma, P.W., Tomassen, J.   +4 more
openaire   +9 more sources

Protein phosphorylation in chemotaxis and two-component regulatory systems of bacteria [PDF]

Journal of Biological Chemistry, 1989
Two-component regulatory systems appear to be widespread in bacteria. Phosphorylation has been demonstrated in three of the known systems and correlated with in vivo function in two cases (Che and Ntr). Although phosphorylation of sensor and regulator proteins has so far been observed exclusively in vitro, transient protein phosphorylation could ...
R B, Bourret, J F, Hess, K A, Borkovich, A A, Pakula, M I, Simon   +4 more
openaire   +3 more sources

A comprehensive analysis of pneumococcal two-component system regulatory networks [PDF]

NAR Genomics and Bioinformatics
Abstract Two-component systems are key signal-transduction systems that enable bacteria to respond to a wide variety of environmental stimuli. The human pathogen, Streptococcus pneumoniae (pneumococcus) encodes 13 two-component systems and a single orphan response regulator, most of which are significant for pneumococcal pathogenicity ...
Jens Sivkær Pettersen, Flemming Damgaard Nielsen, Patrick Rosendahl Andreassen, Jakob Møller-Jensen, Mikkel Girke Jørgensen   +4 more
openaire   +6 more sources