Results 21 to 30 of about 262,707 (218)

Two-Photon Excitation of Azobenzene Photoswitches for Synthetic Optogenetics

open access: yesApplied Sciences, 2020
Synthetic optogenetics is an emerging optical technique that enables users to photocontrol molecules, proteins, and cells in vitro and in vivo. This is achieved by use of synthetic chromophores—denoted photoswitches—that undergo light ...
Shai Kellner, Shai Berlin
doaj   +1 more source

Reliable and Elastic Propagation of Cortical Seizures In Vivo

open access: yesCell Reports, 2017
Mapping the fine-scale neural activity that underlies epilepsy is key to identifying potential control targets of this frequently intractable disease.
Michael Wenzel   +3 more
doaj   +1 more source

Maskless Writing of Surface-Attached Micro-Magnets by Two-Photon Crosslinking

open access: yesActuators, 2023
Surface-bound 3D micro-magnets are fabricated from photoreactive copolymers filled with magnetic nanoparticles by maskless 3D writing. The structures are generated by 2-photon crosslinking (2PC), which allows direct writing into solid films of composites
Nicolas Geid   +3 more
doaj   +1 more source

Ca2+ signaling in arterioles and small arteries of conscious, restrained optical biosensor mice

open access: yesFrontiers in Physiology, 2014
Two-photon fluorescence microscopy and conscious, restrained optical biosensor mice were used to study smooth muscle Ca2+ signaling in ear arterioles. Conscious mice were used in order to preserve normal mean arterial blood pressure (MAP) and sympathetic
Seth T. Fairfax   +5 more
doaj   +1 more source

A FRET Based Two-Photon Fluorescent Probe for Visualizing Mitochondrial Thiols of Living Cells and Tissues

open access: yesSensors, 2020
Glutathione (GSH) is the main component of the mitochondrial thiol pool and plays key roles in the biological processes. Many evidences have suggested that cysteine and homocysteine also exist in mitochondria and are interrelated with GSH in biological ...
Zhengkun Liu   +4 more
doaj   +1 more source

A laser–plasma platform for photon–photon physics: the two photon Breit–Wheeler process

open access: yesNew Journal of Physics, 2021
We describe a laser–plasma platform for photon–photon collision experiments to measure fundamental quantum electrodynamic processes. As an example we describe using this platform to attempt to observe the linear Breit–Wheeler process.
B Kettle   +37 more
doaj   +1 more source

Synaptic Loss in Alzheimer's Disease: Mechanistic Insights Provided by Two-Photon in vivo Imaging of Transgenic Mouse Models

open access: yesFrontiers in Cellular Neuroscience, 2020
Synapse loss is the strongest correlate for cognitive decline in Alzheimer's disease. The mechanisms underlying synapse loss have been extensively investigated using mouse models expressing genes with human familial Alzheimer's disease mutations. In this
Jaichandar Subramanian   +5 more
doaj   +1 more source

Molecular design strategy to alleviate environmental interference on two-photon fluorescence probes

open access: yesCell Reports Physical Science, 2021
Summary: Electron donor-acceptor (D-A)-type molecules are the most widely employed two-photon scaffolds. Unfortunately, current D-A-type fluorophores suffer from serious solvent-dependent emission wavelength and brightness, thwarting their use for high ...
Xingxing Zhang   +7 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

open access: yesFEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

MEMS Actuators for Optical Microendoscopy

open access: yesMicromachines, 2019
Growing demands for affordable, portable, and reliable optical microendoscopic imaging devices are attracting research institutes and industries to find new manufacturing methods.
Zhen Qiu, Wibool Piyawattanametha
doaj   +1 more source

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