Results 11 to 20 of about 510,182 (210)
The chemotherapeutic agent DMXAA as a unique IRF3-dependent type-2 vaccine adjuvant [PDF]
, 2013 5,6-Dimethylxanthenone-4-acetic acid (DMXAA), a potent type I interferon (IFN) inducer, was evaluated as a chemotherapeutic agent in mouse cancer models and proved to be well tolerated in human cancer clinical trials.
Akira, S +11 more
core +5 more sources
Type I Interferons in NeuroHIV [PDF]
Viral Immunology, 2019 Infection with Human Immunodeficiency Virus (HIV)-1 continues to cause HIV-associated neurocognitive disorders despite combined antiretroviral therapy. Interferons (IFNs) are important for any antiviral immune response, but the lasting production of IFNα causes exhaustive activation leading eventually to progression to AIDS.
Thaney, Victoria E, Kaul, Marcus
openaire +4 more sources
Insights Into Type I and III Interferons in Asthma and Exacerbations
Frontiers in Immunology, 2020 Asthma is a highly prevalent, chronic respiratory disease that impacts millions of people worldwide and causes thousands of deaths every year.
Helen E. Rich +4 more
doaj +1 more source
Type I interferon: potential therapeutic target for psoriasis? [PDF]
PLoS ONE, 2008 BACKGROUND: Psoriasis is an immune-mediated disease characterized by aberrant epidermal differentiation, surface scale formation, and marked cutaneous inflammation.
Yihong Yao +10 more
doaj +1 more source
Biomolecules, 2021 There is a great deal of evidence pointing to interferons (IFNs) as being key cytokines in the pathogenesis of different systemic autoimmune diseases, including primary Sjögren’s syndrome (pSS).
Nicoletta Del Papa +8 more
doaj +1 more source
Type-I interferons in atherosclerosis [PDF]
Journal of Experimental Medicine, 2019 The contribution of dyslipidemia and inflammation in atherosclerosis is well established. Along with effective lipid-lowering treatments, the recent success of clinical trials with anti-inflammatory therapies and the accelerated atherosclerosis in many autoimmune diseases suggest that targeting inflammation may open new avenues for the prevention and ...
Hung-Jen Chen +2 more
openaire +2 more sources
Inhibition of type I interferon induction and signalling by mosquito-borne flaviviruses [PDF]
, 2017 The Flavivirus genus (Flaviviridae family) contains a number of important human pathogens, including dengue and Zika viruses, which have the potential to cause severe disease.
Clark, Jordan J. +3 more
core +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background We previously demonstrated that ischemically injured cardiomyocytes release cell‐free DNA and HMGB1 (high mobility group box 1 protein) into circulation during reperfusion, activating proinflammatory responses and ultimately exacerbating ...
Lina Lai +5 more
doaj +1 more source
Antiproliferative Properties of Type I and Type II Interferon
Pharmaceuticals, 2010 The clinical possibilities of interferon (IFN) became apparent with early studies demonstrating that it was capable of inhibiting tumor cells in culture and in vivo using animal models.
Joseph Bekisz +4 more
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2021 Background Improvement of radiotherapy efficacy requires better insight in the dynamic responses that occur during irradiation. Here, we aimed to identify the molecular responses that are triggered during clinically applied fractionated irradiation ...
Ruben S. A. Goedegebuure +15 more
doaj +1 more source