Results 11 to 20 of about 1,669,550 (354)
Immunological Reviews, 2023 Type I interferon (IFN) is a class of proinflammatory cytokines with a dual role on malignant transformation, tumor progression, and response to therapy.
P. Holicek +6 more
semanticscholar +3 more sources
Bunyaviruses and the Type I Interferon System [PDF]
Viruses, 2009 The family Bunyaviridae contains more than 350 viruses that are distributed throughout the world. Most members of the family are transmitted by arthopods, and several cause disease in man, domesticated animals and crop plants. Despite being recognized as
Richard M. Elliott, Friedemann Weber
doaj +6 more sources
Type I Interferon in Human Autoimmunity [PDF]
Frontiers in Immunology, 2014 The type I interferon system plays a critical role in host defense in health, and a growing body of literature suggests that type I interferon is a critical mediator of human autoimmune disease. Type I interferons function as a bridge between the innate and adaptive immune systems, and as such play an important role in setting thresholds for response ...
Timothy B. Niewold
doaj +4 more sources
Regulation of type I interferon responses [PDF]
Nature Reviews Immunology, 2013 Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the development of innate and adaptive immune responses. Canonical type I IFN signalling activates the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway, leading to transcription of IFN-stimulated genes (ISGs).
L. Ivashkiv, L. Donlin
semanticscholar +3 more sources
Type I interferon-mediated tumor immunity and its role in immunotherapy
Cellular and Molecular Life Sciences, 2022 Immune checkpoint blockade (ICB) therapies have achieved remarkable clinical responses in patients with many different types of cancer; however, most patients who receive ICB monotherapy fail to achieve long-term responses, and some tumors become ...
Renren Yu, B. Zhu, Degao Chen
semanticscholar +1 more source
Science Translational Medicine, 2021 Description Type I interferon autoantibodies in patients with COVID-19 are associated with poor interferon responses and increased LAIR1 abundance in leukocytes.
M. V. D. van der Wijst +44 more
semanticscholar +1 more source
Activation and evasion of type I interferon responses by SARS-CoV-2
Nature Communications, 2020 The pandemic of COVID-19 has posed an unprecedented threat to global public health. However, the interplay between the viral pathogen of COVID-19, SARS-CoV-2, and host innate immunity is poorly understood.
X. Lei +14 more
semanticscholar +1 more source
Type I interferon–related kidney disorders
Kidney International, 2022 Type I interferon (IFN-I) mediates tissue damage in a wide range of kidney disorders, directly affecting the biology and function of several renal cell types including podocytes, mesangial, endothelial, and parietal epithelial cells. Enhanced IFN-I signaling is observed in the context of viral infections, autoimmunity (e.g., systemic lupus ...
Lodi, Lorenzo +7 more
openaire +4 more sources
Type I Interferons in NeuroHIV [PDF]
Viral Immunology, 2019 Infection with Human Immunodeficiency Virus (HIV)-1 continues to cause HIV-associated neurocognitive disorders despite combined antiretroviral therapy. Interferons (IFNs) are important for any antiviral immune response, but the lasting production of IFNα causes exhaustive activation leading eventually to progression to AIDS.
Thaney, Victoria E, Kaul, Marcus
openaire +4 more sources
Insights Into Type I and III Interferons in Asthma and Exacerbations
Frontiers in Immunology, 2020 Asthma is a highly prevalent, chronic respiratory disease that impacts millions of people worldwide and causes thousands of deaths every year.
Helen E. Rich +4 more
doaj +1 more source