Loss of Ifnar1 in Pancreatic Acinar Cells Ameliorates the Disease Course of Acute Pancreatitis. [PDF]
PLoS ONE, 2015 Type I interferon constitutes an essential component of the combinational therapy against viral disease. Acute pancreatitis is one side effect of type I interferon-based therapy, implying that activation of type I interferon signaling affects the ...
Katharina J Miller +7 more
doaj +1 more source
Shared and Unique Features of Human Interferon-Beta and Interferon-Alpha Subtypes
Frontiers in Immunology, 2021 Type I interferons (IFN-I) were first discovered as an antiviral factor by Isaacs and Lindenmann in 1957, but they are now known to also modulate innate and adaptive immunity and suppress proliferation of cancer cells.
Megen C. Wittling +3 more
doaj +1 more source
Paramyxovirus V proteins interact with the RNA helicase LGP2 to inhibit RIG-I-dependent interferon induction [PDF]
, 2012 This work was supported by the Wellcome Trust (grant AL087751/B)RIG-I and mda-5 are activated by viral RNA and stimulate type I interferon production. Laboratory of genetics and physiology 2 (LGP2) shares homology with RIG-I and mda-5 but lacks the CARD ...
Childs, Kay +2 more
core +1 more source
Phleboviruses and the Type I Interferon Response
Viruses, 2016 The genus Phlebovirus of the family Bunyaviridae contains a number of emerging virus species which pose a threat to both human and animal health. Most prominent members include Rift Valley fever virus (RVFV), sandfly fever Naples virus (SFNV), sandfly ...
Jennifer Deborah Wuerth +1 more
doaj +1 more source
Pro-inflammatory signaling by IL-10 and IL-22: bad habit stirred up by interferons? [PDF]
, 2013 Interleukin (IL)-10 and IL-22 are key members of the IL-10 cytokine family that share characteristic properties such as defined structural features, usage of IL-10R2 as one receptor chain, and activation of signal transducer and activator of ...
Mühl, Heiko
core +2 more sources
STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during Chlamydia trachomatis infection. [PDF]
, 2013 UnlabelledSTING (stimulator of interferon [IFN] genes) initiates type I IFN responses in mammalian cells through the detection of microbial nucleic acids. The membrane-bound obligate intracellular bacterium Chlamydia trachomatis induces a STING-dependent
Barker, Jeffrey R +6 more
core +2 more sources
Differential induction of TLR3-dependent innate immune signaling by closely related parasite species. [PDF]
PLoS ONE, 2014 The closely related protozoan parasites Toxoplasma gondii and Neospora caninum display similar life cycles, subcellular ultrastructure, invasion mechanisms, metabolic pathways, and genome organization, but differ in their host range and disease ...
Daniel P Beiting +8 more
doaj +1 more source
Type I interferon, anti-interferon antibodies, and COVID-19 [PDF]
The Lancet Rheumatology, 2021 Author(s): Calabrese, Leonard H; Winthrop, Kevin; Strand, Vibeke; Yazdany, Jinoos; Walter, Jolan ...
Calabrese, Leonard H +4 more
openaire +4 more sources
EHMT1 Protein Binds to Nuclear Factor-κB p50 and Represses Gene Expression [PDF]
, 2012 Transcriptional homeostasis relies on the balance between positive and negative regulation of gene transcription. Methylation of histone H3 lysine 9 (H3K9) is commonly correlated with gene repression.
Baltimore, David +3 more
core +1 more source
Type I/II interferon in HIV-1-infected patients: expression in gut mucosa and in peripheral blood mononuclear cells and its modification upon probiotic supplementation [PDF]
, 2018 Expression of type I and II interferon (IFN) was evaluated in gut-associated lymphoid tissue (GALT) and peripheral blood mononuclear cells (PBMCs) of HIV-1-positive patients on long-term, suppressive, antiretroviral therapy before and after probiotic ...
Antonelli, Guido +10 more
core +1 more source