Results 1 to 10 of about 259,068 (324)

The Type VI secretion system:a versatile bacterial weapon [PDF]

Microbiology, 2019
The Type VI secretion system (T6SS) is a protein nanomachine that is widespread in Gram-negative bacteria and is used to translocate effector proteins directly into neighbouring cells. It represents a versatile bacterial weapon that can deliver effectors
Coulthurst, Sarah
core   +6 more sources

Characterization of Type VI secretion system in Edwardsiella ictaluri. [PDF]

PLoS ONE, 2023
Edwardsiella ictaluri is a Gram-negative facultative intracellular fish pathogen causing enteric septicemia of catfish (ESC). While various secretion systems contribute to E.
Safak Kalindamar, Hossam Abdelhamed, Adef O Kordon, Hasan C Tekedar, Lesya Pinchuk, Attila Karsi   +5 more
doaj   +4 more sources

Identification of type VI secretion system effector-immunity pairs using structural bioinformatics [PDF]

Molecular Systems Biology
The type VI secretion system (T6SS) is an important mediator of microbe–microbe and microbe–host interactions. Gram-negative bacteria use the T6SS to inject T6SS effectors (T6Es), which are usually proteins with toxic activity, into neighboring cells ...
Alexander M Geller, Maor Shalom, David Zlotkin, Noam Blum, Asaf Levy   +4 more
doaj   +3 more sources

A Transcriptional Regulatory Mechanism Finely Tunes the Firing of Type VI Secretion System in Response to Bacterial Enemies [PDF]

mBio, 2017
The ability to detect and measure danger from an environmental signal is paramount for bacteria to respond accordingly, deploying strategies that halt or counteract potential cellular injury and maximize survival chances. Type VI secretion systems (T6SSs)
Martina Lazzaro, Mario F. Feldman, Eleonora García Véscovi   +2 more
doaj   +4 more sources

PAAR-repeat proteins sharpen and diversify the Type VI secretion system spike [PDF]

Nature, 2013
The bacterial type VI secretion system (T6SS) is a large multi-component, dynamic macromolecular machine that plays an important role in the ecology of many Gram negative bacteria.
A Hachani, A Marchler-Bauer, AJ McCoy, Brian T. Ho, C Felisberto-Rodrigues, E Krissinel, EF Pettersen, GE Crooks, GN Murshudov, J Kyte, J Schindelin, J Söding, JA Bearden, JD Mougous, John J. Mekalanos, JP Fürste, LM Guzman, LY Geer, M Basler, M Basler, Marek Basler, MG Rossmann, Mikhail M. Shneider, N Kapitein, P Emsley, P Emsley, PD Adams, Petr G. Leiman, PG Leiman, RD Finn, RD Finn, S Kanamaru, S Koskiniemi, S Pukatzki, S Pukatzki, Sergey A. Buth, SF Altschul, TG Dong, VA Kostyuchenko, W Kabsch, Y Kikuchi, ZA Hamburger   +41 more
core   +2 more sources

Klebsiella pneumoniae employs a type VI secretion system to overcome microbiota-mediated colonization resistance. [PDF]

Nat Commun
Microbial species must compete for space and nutrients to persist in the gastrointestinal (GI) tract, and our understanding of the complex pathobiont-microbiota interactions is far from complete. Klebsiella pneumoniae, a problematic, often drug-resistant
Bray AS, Broberg CA, Hudson AW, Wu W, Nagpal RK, Islam M, Valencia-Bacca JD, Shahid F, Hernandez GE, Nutter NA, Walker KA, Bennett EF, Young TM, Barnes AJ, Ornelles DA, Miller VL, Zafar MA.   +16 more
europepmc   +2 more sources

The Vibrio cholerae Type VI Secretion System: Evaluating Its Role in the Human Disease Cholera [PDF]

Frontiers in Cellular and Infection Microbiology, 2010
Vibrio cholerae, the marine bacterium responsible for the diarrheal disease cholera, utilizes a multitude of virulence factors to cause disease. The importance of two of these factors, the toxin co-regulated pilus (TCP) and cholera toxin (CT), has been ...
Sarah T. Miyata, Maya eKitaoka, Lukasz eWieteska, Christian eFrech, Nansheng eChen, Stefan ePukatzki   +5 more
doaj   +2 more sources

The Role of Type VI Secretion System Effectors in Target Cell Lysis and Subsequent Horizontal Gene Transfer [PDF]

Cell Reports, 2017
Bacteria use type VI secretion systems (T6SSs) to manipulate host cells during pathogenesis or to kill competing bacteria, which, in some cases, increases horizontal gene transfer.
Basler, Marek, Hu, Di, Ringel, Peter David   +2 more
core   +9 more sources

Intramolecular chaperone-mediated secretion of an Rhs effector toxin by a type VI secretion system

Nature Communications, 2020
Bacterial Rhs proteins with toxic domains are often secreted by type VI secretion systems. Here, the authors show that one of these proteins self-cleaves into three fragments, with the Rhs core and the N-terminal domain facilitating secretion and ...
Tong-Tong Pei, Hao Li, Xiaoye Liang, Zeng-Hang Wang, Guangfeng Liu, Li-Li Wu, Haeun Kim, Zhiping Xie, Ming Yu, Shuangjun Lin, Ping Xu, Tao G. Dong   +11 more
doaj   +2 more sources

VgrG and PAAR Proteins Define Distinct Versions of a Functional Type VI Secretion System [PDF]

PLoS Pathogens, 2016
The Type VI secretion system (T6SS) is widespread among bacterial pathogens and acts as an effective weapon against competitor bacteria and eukaryotic hosts by delivering toxic effector proteins directly into target cells.
A Hachani, A Hachani, A Iguchi, AB Russell, AB Russell, AB Russell, AJ Gerc, AP Jackson, AT Ma, D Unterweger, DL MacIntyre, E Durand, E Durand, Eric Cascales, F Jiang, FR Cianfanelli, Francesca R. Cianfanelli, G English, G English, G Karimova, G Karimova, GM Li, IJ Toesca, J Alcoforado Diniz, J Alcoforado Diniz, J Cox, JC Whitney, JC Whitney, JC Whitney, JM Silverman, Juliana Alcoforado Diniz, LS Ma, M Basler, M Kudryashev, Manman Guo, Matthias Trost, MD Carruthers, MJ Fritsch, MM Shneider, N Flaugnatti, PG Leiman, PG Leiman, RD Hood, S Koskiniemi, S Schwarz, Sarah J. Coulthurst, SD Mahlen, SL Murdoch, ST Miyata, TG Sana, TM Brooks, TR Costa, V Srikannathasan, Virginia De Cesare, X Liang, YR Brunet, YR Brunet   +56 more
core   +5 more sources