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Adaptor Proteins of Type VI Secretion System Effectors [PDF]

Trends in Microbiology, 2017
Bacteria use the type VI secretion system (T6SS) to kill neighboring cells. One key feature of the T6SS is the secretion of diverse effectors. Here, we discuss six publications that describe three superfamilies of T6SS proteins, each dedicated to mediate the secretion of cognate effectors.
Unterweger, D, Kostiuk, B, Pukatzki, S
openaire   +2 more sources

Type VI secretion system effector proteins: effective weapons for bacterial competitiveness.

Cellular Microbiology, 2020
The Type VI secretion system (T6SS) is a protein translocation nanomachine widespread amongst Gram-negative bacteria and used as a means to deliver effectors directly into target bacterial or eukaryotic cells.
Ruth E Hernandez, Ramses Gallegos-Monterrosa, Sarah J. Coulthurst   +2 more
semanticscholar   +1 more source

Type VI Secretion System Helps Find a Niche [PDF]

Cell Host & Microbe, 2014
Type VI secretion systems (T6SSs) deliver toxins into target cells and thus play a role in bacterial warfare. In this issue of Cell Host & Microbe, Ma et al. (2014) demonstrate that T6SS-dependent attack during interbacterial competition in the host context enables niche colonization by Agrobacterium tumefaciens.
Kapitein, Nicole, Mogk, Axel
openaire   +2 more sources

Integrating signals to drive type VI secretion system killing [PDF]

Environmental Microbiology, 2020
Ministerio de Ciencia, Innovación y Universidades RTI2018-096936-J ...
Patricia Bernal, Marina Murillo‐Torres, Luke P. Allsopp   +2 more
openaire   +4 more sources

Constitutive Type VI Secretion System Expression Gives Vibrio cholerae Intra- and Interspecific Competitive Advantages [PDF]

, 2012
The type VI secretion system (T6SS) mediates protein translocation across the cell membrane of Gram-negative bacteria, including Vibrio cholerae – the causative agent of cholera. All V.
AB Russell, AT Ma, AT Ma, CE Miller, CS Bernard, D Provenzano, Daniel Unterweger, Daniele Provenzano, David Silva, DL MacIntyre, ER Ballister, F Qadri, G Jonson, GA Losonsky, J Zheng, J Zheng, Jessica Moloney, Jorge Duran-Gonzalez, L De Haan, LM Guzman, LS Ma, LS Ma, M Basler, M Kitaoka, M Sussman, Maya Kitaoka, NF Pierce, Oscar Sosa, PA Blake, PG Leiman, RD Hood, RG Gerlach, RK Gupta, RK Mitra, RR Colwell, S Das, S Pukatzki, S Pukatzki, Sarah T. Miyata, SG Williams, Stefan Pukatzki, T Vesth, Teresa M. Brooks, Thierry Soldati, TJ Kirn, Verena Bachmann, VT Lee, WW Metcalf   +47 more
core   +10 more sources

The ecological impact of a bacterial weapon: microbial interactions and the Type VI secretion system

FEMS Microbiology Reviews, 2021
Bacteria inhabit all known ecological niches and establish interactions with organisms from all kingdoms of life. These interactions are mediated by a wide variety of mechanisms and very often involve the secretion of diverse molecules from the bacterial
Ramses Gallegos-Monterrosa, Sarah J. Coulthurst   +1 more
semanticscholar   +1 more source

Structure and regulation of the type VI secretion system. [PDF]

Annual Review of Microbiology, 2012
The type VI secretion system (T6SS) is a complex and widespread gram-negative bacterial export pathway with the capacity to translocate protein effectors into a diversity of target cell types. Current structural models of the T6SS indicate that the apparatus is composed of at least two complexes, a dynamic bacteriophage-like structure and a cell ...
J. M. Silverman, Yannick R Brunet, É. Cascales, J. D. Mougous   +3 more
semanticscholar   +3 more sources

Type VI Secretion Systems and the Gut Microbiota [PDF]

Microbiology Spectrum, 2019
ABSTRACT The human colonic microbiota is a dense ecosystem comprised of numerous microbes, including bacteria, phage, fungi, archaea, and protozoa, that compete for nutrients and space. Studies are beginning to reveal the antagonistic mechanisms that gut bacteria use to compete with other members of this ecosystem. In the healthy
Michael J, Coyne, Laurie E, Comstock
openaire   +2 more sources

Bacterial type VI secretion system facilitates niche domination [PDF]

Proceedings of the National Academy of Sciences, 2018
Over the last few decades humanity has experienced a series of tremendous technological advances, especially in the realm of basic science. A plethora of new approaches has allowed us to appreciate life in previously unimaginable detail, prompting the realization that life in the microscopic world is not so different from what we can observe with our ...
Drebes Dörr, Natália C., Blokesch, Melanie   +1 more
openaire   +2 more sources

Molecular weaponry:diverse effectors delivered by the Type VI secretion system [PDF]

, 2015
The Type VI secretion system is a widespread bacterial nanomachine, used to deliver toxins directly into eukaryotic or prokaryotic target cells. These secreted toxins, or effectors, act on diverse cellular targets, and their action provides the attacking
Alcoforado Diniz, Juliana, Coulthurst, Sarah J., Liu, Yi-Chia   +2 more
core   +2 more sources