Results 51 to 60 of about 259,068 (324)

Microfluidics-based liquid chromatography/mass spectrometry multiple reaction monitoring approach for the relative quantification of Burkholderia cenocepacia secreted virulence factors [PDF]

, 2018
Rationale: Burkholderia cenocepacia is an opportunistic pathogen that is commonly isolated from patients with cystic fibrosis (CF). Quorum sensing has been suggested to play a role in the activity of type II and type VI secretion systems and the release ...
Daled, Simon, De Waele, Stijn, Deforce, Dieter, Depluverez, Sofie, Devreese, Bart, Planckaert, Sören, Schoovaerts, Jolien   +6 more
core   +2 more sources

Trade-offs constrain adaptive pathways to type VI secretion system survival

iScience, 2023
Summary: The Type VI Secretion System (T6SS) is a nano-harpoon used by many bacteria to inject toxins into neighboring cells. While much is understood about mechanisms of T6SS-mediated toxicity, less is known about the ways that competitors can defend ...
Kathryn A. MacGillivray, Siu Lung Ng, Sophia Wiesenfeld, Randi L. Guest, Tahrima Jubery, Thomas J. Silhavy, William C. Ratcliff, Brian K. Hammer   +7 more
doaj   +1 more source

Biochemical analysis of TssK, a core component of the bacterial Type VI secretion system, reveals distinct oligomeric states of TssK and identifies a TssK–TssFG subcomplex [PDF]

, 2014
Gram-negative bacteria use the Type VI secretion system (T6SS) to inject toxic proteins into rival bacteria or eukaryotic cells. However, the mechanism of the T6SS is incompletely understood. In the present study, we investigated a conserved component of
Alan R. Prescott, Aschtgen, Aschtgen, Aschtgen, Aschtgen, Ballister, Basler, Basler, Bonemann, Bonemann, Boyer, Burtnick, Casabona, Casabona, Cascales, Coulthurst, Dong, English, Felisberto-Rodrigues, Francesca R. Cianfanelli, Fritsch, Gerlach, Grant English, Holland, Hood, Jack, Kaniga, Kapitein, Kapitein, Laue, Leiman, Leiman, Lossi, Ma, Ma, Ma, MacIntyre, Mougous, Murdoch, Olwyn Byron, Pell, Potvin, Pukatzki, Rao, Rickman, Russell, Russell, Sambrook, Sarah J. Coulthurst, Schell, Schuck, Schwarz, Shneider, Silverman, Srikannathasan, Suarez, Vistica, Whitney, Zheng, Zheng, Zoued   +60 more
core   +3 more sources

Tagging the type VI secretion system [PDF]

Nature Microbiology, 2018
Bacteria use multiple mechanisms to secrete proteins across their envelope and gain access to resources in their niche. The type VI secretion system (T6SS) specializes in injecting toxic protein effectors by direct contact, killing the target eukaryotic or bacterial cells1.
openaire   +2 more sources

Two Independent Pathways for Self-Recognition in Proteus Mirabilis Are Linked by Type VI-Dependent Export [PDF]

, 2013
Swarming colonies of the bacterium Proteus mirabilis are capable of self-recognition and territorial behavior. Swarms of independent P. mirabilis isolates can recognize each other as foreign and establish a visible boundary where they meet; in contrast ...
Cardarelli, L., Gibbs, Karine Alexine, Septer, Alecia Noelle, Sullivan, N. L., Wenren, Larissa Man-Yin   +4 more
core   +2 more sources

Comparative Genomics of Aeromonas hydrophila Secretion Systems and Mutational Analysis of hcp1 and vgrG1 Genes From T6SS

Frontiers in Microbiology, 2019
Virulent Aeromonas hydrophila causes severe motile Aeromonas septicemia in warmwater fishes. In recent years, channel catfish farming in the U.S.A. and carp farming in China have been affected by virulent A.
Hasan C. Tekedar, Hossam Abdelhamed, Salih Kumru, Jochen Blom, Attila Karsi, Mark L. Lawrence   +5 more
doaj   +1 more source

Type VI secretion system: secretion by a contractile nanomachine [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2015
The type VI secretion systems (T6SS) are present in about a quarter of all Gram-negative bacteria. Several key components of T6SS are evolutionarily related to components of contractile nanomachines such as phages and R-type pyocins. The T6SS assembly is initiated by formation of a membrane complex that binds a phage-like baseplate with a sharp spike ...
openaire   +4 more sources

Expression of Francisella pathogenicity island protein intracellular growth locus E (IglE) in mammalian cells is involved in intracellular trafficking, possibly through microtubule organizing center

MicrobiologyOpen, 2019
Francisella tularensis is the causative agent of the infectious disease tularemia and is designated a category A bioterrorism agent. The type VI secretion system encoded by the Francisella pathogenicity island (FPI) is necessary for intracellular growth;
Takashi Shimizu, Shiho Otonari, Jin Suzuki, Akihiko Uda, Kenta Watanabe, Masahisa Watarai   +5 more
doaj   +1 more source

Comparative genomic analysis of multiple strains of two unusual plant pathogens: Pseudomonas corrugata and Pseudomonas mediterranea

Frontiers in Microbiology, 2015
The non-fluorescent pseudomonads, Pseudomonas corrugata (Pcor) and P. mediterranea (Pmed), are closely related species that cause pith necrosis, a disease of tomato that causes severe crop losses.
Emmanouil A Trantas, Grazia eLicciardello, Nalvo F Almeida, Kamil eWitek, Cinzia P Strano, Zane eDuxbury, Filippos eVerveridis, Dimitrios E Goumas, Jonathan DG Jones, David S Guttman, Vittoria eCatara, Panagotis F. Sarris   +11 more
doaj   +1 more source

The type VI secretion system of the emerging pathogen Stenotrophomonas maltophilia complex has antibacterial properties

mSphere, 2023
Antagonistic behaviors between bacterial cells can have profound effects on microbial populations and disease outcomes. Polymicrobial interactions may be mediated by contact-dependent proteins with antibacterial properties.
Cristian V. Crisan, Daria Van Tyne, Joanna B. Goldberg   +2 more
doaj   +1 more source