Tyrosinase Inhibitor Activity of Coumarin-Resveratrol Hybrids [PDF]
Molecules, 2009 In the present work we report on the contribution of the coumarin moiety to tyrosinase inhibition. Coumarin-resveratrol hybrids 1-8 have been resynthesized to investigate the structure-activity relationships and the IC50 values of these compounds were ...
Giovanna Delogu +9 more
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Newly Designed Quinazolinone Derivatives as Novel Tyrosinase Inhibitor: Synthesis, Inhibitory Activity, and Mechanism [PDF]
Molecules, 2022 We synthesized a series of quinazolinone derivates as tyrosinase inhibitors and evaluated their inhibition constants. We synthesized 2-(2,6-dimethylhepta-1,5-dien-1-yl)quinazolin-4(3H)-one (Q1) from the natural citral. The concentration, which led to 50%
Yaru Huang +8 more
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Multifunctional Tyrosinase Inhibitor Peptides with Copper Chelating, UV-Absorption and Antioxidant Activities: Kinetic and Docking Studies [PDF]
Foods, 2021 Nature-derived tyrosinase inhibitors are of great industrial interest. Three monophenolase inhibitor peptides (MIPs) and three diphenolase inhibitor peptides (DIPs) from a previous study were investigated for their in vitro tyrosinase inhibitory effects,
Pei-Gee Yap, Chee-Yuen Gan
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Biochemical Properties of Tyrosinase from Aspergillus terreus and Penicillium copticola; Undecanoic Acid from Aspergillus flavus, an Endophyte of Moringa oleifera, Is a Novel Potent Tyrosinase Inhibitor [PDF]
Molecules, 2021 Tyrosinase is a copper-containing monooxygenase catalyzing the O-hydroxylation of tyrosine to 3,4-dihydroxyphenylalanine then to dopaquinone that is profoundly involved in melanin synthesis in eukaryotes.
Hanaa Salah Maamoun +4 more
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Tyrosinase Inhibitors: A Perspective
Molecules, 2023 Due to its integral role in the biosynthesis of melanin in all kingdoms of life, tyrosinase has become an extremely important target for inhibition in several sectors of research including agricultural and cosmetic research. Inhibitors of tyrosinase have
Mason A. Baber +3 more
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Palladium(II)-Catalyzed Efficient Synthesis of Wedelolactone and Evaluation as Potential Tyrosinase Inhibitor [PDF]
Molecules, 2019 Tyrosinase is an enzyme widely distributed in nature, which has multiple functions, especially in the melanin biosynthesis pathway. Despite the few clinically available tyrosinase inhibitors for whitening, a great demand remains for novel compounds with ...
Huidan Huang +4 more
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A tyrosinase inhibitor from Aspergillus niger. [PDF]
J Food Sci Technol, 2014 Tyrosinase, in the presence of oxygen, is the main culprit in post harvest browning of food products, resulting in the drop in its commercial value. In an effort to seek natural tyrosinase inhibitors for food applications, a screening programme was undertaken. Of the 26 fungal cultures isolated from soil samples of Agumbe forest, India, one isolate S16,
Vasantha KY, Murugesh CS, Sattur AP.
europepmc +4 more sources
Boronic Derivatives of Thiosemicarbazones as Tyrosinase Inhibitors [PDF]
PharmaceuticsBackground: Tyrosinase is a copper-dependent oxyreductase capable of catalyzing the oxidation of mono- and diphenols. Its activity is crucial in the biosynthetic pathway of melanin, the pigment responsible for the pigmentation of mammalian skin and fur ...
Michał Jewgiński +4 more
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Molecules, 2023 Tyrosinase is an important rate-limiting enzyme in melanin biosynthesis. To find potential tyrosinase inhibitors with anti-melanogenic activity, a series of indole-thiazolidine-2,4-dione derivatives 5a~5z were synthesized by incorporating indole with ...
Li Lu +5 more
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Identification by shape-based virtual screening and evaluation of new tyrosinase inhibitors [PDF]
PeerJ, 2018 Targeting tyrosinase is considered to be an effective way to control the production of melanin. Tyrosinase inhibitor is anticipated to provide new therapy to prevent skin pigmentation, melanoma and neurodegenerative diseases.
Qi Li +7 more
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